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| Content Provider | frontiers |
|---|---|
| Author | Yin, Zhiyang Chang, Miao Wei, Shengnan Jiang, Xiaowei Zhou, Yifang Cui, Lingling Lv, Jing Wang, Fei Tang, Yanqing |
| Abstract | Objective: Clinically, it is very difficult to distinguish between major depressive disorder (MDD) and bipolar disorder (BD) in the period of depression. Increasing evidence shows that the insula is important in depression. We aimed to compare the resting-state functional connectivity (rsFC) of insular subregions in patients with MDD and BD in depressive episodes (BDD), who had never experienced manic or hypomanic episodes when they were scanned to identify biomarkers for the identification of two diseases. Method: We recruited 21 BDD patients, 40 MDD patients and 70 healthy controls (HC). Resting-state functional magnetic resonance imaging (rs-fMRI) was performed. BDD patients had never had manic or hypomanic episodes when they were scanned, and the diagnoses were determined by follow-up. We divided the insula into three parts including the ventral anterior insular cortex (v-AIN), dorsal anterior insular cortex (d-AIN) and posterior insula (PI). The insular-based rsFC was compared among the three groups, and an analysis of the correlation between the rsFC value and clinical scale was carried out. Results: BDD and MDD patients demonstrated decreased rsFC from the v-AIN to the left superior /middle frontal gyrus compared with the HC group. Versus MDD and HC groups, BDD patients exhibited decreased rsFC from the v-AIC to the area in the left orbital frontal gyrus and left superior temporal gyrus (included temporal pole), from the PI to the right lateral postcentral gyrus and from all three insular subregions to the somatosensory and motor cortex. Meanwhile, a correlation between the rsFC value of the PI-right lateral postcentral gyrus and anxiety score was observed in patients. Conclusion: BDD and MDD patients indicate similar decreases in insular connectivity in the dorsal lateral frontal regions, and BDD patients have specific decreased insular connectivity, especially in the somatosensory and motor cortex, which may be used as imaging evidence for clinical identification. |
| ISSN | 1662453X |
| DOI | 10.3389/fnins.2018.00842 |
| Volume Number | 12 |
| Journal | Frontiers in Neuroscience |
| Language | English |
| Publisher Date | 2018-11-14 |
| Access Restriction | Open |
| Subject Keyword | Depressive Insula FMRI Bipolar Functional Connectivity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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