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| Content Provider | frontiers |
|---|---|
| Author | Elbadry Ahmed, Rasha Tang, Hailiang Asemota, Anthony Huang, Lei Boling, Warren Bannout, Firas |
| Abstract | Meningiomas are the most common primary brain tumors accounting for about 30% of all brain tumors. The vast majority of meningiomas are slow-growing and of benign histopathology rendering them curable by surgery alone. Symptomatic lesions depend on the location with signs of mass effect or neurological deficits. Seizures are the presenting symptoms in approximately 30% of cases, with percentages ranging from 13-60%. Seizures negatively affect quality of life, limit independence, impair cognitive functioning, as well as increase the risk for psychiatric comorbidities including depression. Although surgical resection may offer seizure freedom in 60-90% of meningiomas, seizures persist after surgical resection in approximately 12-19% of patients. Anti-seizure medications (ASMs) are employed in management, however, are limited by adverse neurocognitive side-effects and inefficacy in some patients. Several potential predictors of pre- and post-operative seizures in meningioma patients have also been identified in the literature. Understanding various factors associated with seizure likelihood in meningioma patients can help guide more effective seizure control and management and allow for better determination of risk before and after surgery. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2022.905976 |
| Volume Number | 12 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2022-07-04 |
| Access Restriction | Open |
| Subject Keyword | Epilepsy Seizure Surgical resection Risk factor Meningiomas Anti-seizure medications |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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