Please wait, while we are loading the content...
| Content Provider | frontiers |
|---|---|
| Author | Baraldi, Carlo Ornello, Raffaele Favoni, Valentina Sacco, Simona Caponnetto, Valeria Pierangeli, Giulia Pani, Luca Cevoli, Sabina Guerzoni, Simona |
| Abstract | Introduction OnabotulinumtoxinA (BT-A) is a preventive treatment for chronic migraine (CM), which needs to be administered regularly by a trained clinician every three month. The spread of the severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) pandemic has forced many patients to momentarily stop the scheduled BT-A injections. The goal of this study was to explore whether those patients experienced a worsening of their CM and, if any, the clinical predictors of migraine worsening after BT-A withdrawal. Methods This was a retrospective, multi-center study. Patients’ clinical data were obtained from their clinical documentation stored at each center. In particular, the following variables were collected: the mean number of headache days in the last month (NHD), the average number of painkillers taken in the last month (AC), the average number of days in which patients took, at least, one painkiller in the last month (NDM), the average intensity of migraine using the numeric rating scale (NRS) score in the last month and the average score obtained at the 6-items Headache Impact Test (HIT-6). The abovementioned variables were compared before and after BT-A withdrawal. Results After BT-A suspension, there was a significant increase in the NHD (P=0.0313, Kruskal-Wallis rank test), AC (P=0.0421, Kruskal-Wallis rank test), NDM (P=0.0394, paired t-test), NRS score (P=0.0069, Kruskal-Wallis rank test) and HIT-6 score (P=0.0372, Kruskal-Wallis rank test). Patients who were not assuming other preventive treatments other than BT-A displayed similar results. Patients who experienced a >30% worsening in NHD after BT-A withdrawn displayed a longer CM history (P=0.001, Kruskal-Wallis rank test), a longer MOH duration (P=0.0017, Kruskal-Wallis rank test), a higher AC value at the baseline (P=0.0149 , Kruskal-Wallis rank test), a higher NDM (P=0.0024, ttest) and a higher average value of the NRS score (P=0.0073, Kruskal-Wallis rank test). Conclusion BT-A withdrawn during SARS-COV-2 pandemic was associated with a general worsening in patients suffering for CM, hence the need to continue BT-A injection, in order to avoid patients’ worsening. |
| ISSN | 16642295 |
| DOI | 10.3389/fneur.2021.647995 |
| Volume Number | 12 |
| Journal | Frontiers in Neurology |
| Language | English |
| Publisher Date | 2021-04-15 |
| Access Restriction | Open |
| Subject Keyword | Migraine frequency Severe acute respiratory syndrome coronavirus-2 pandemic Chronic migraine OnabotulinumtoxinA Medication Overuse Headache |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|