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| Content Provider | frontiers |
|---|---|
| Author | Griffin, Matthew D. Swaminathan, Sundararaman |
| Abstract | Acute kidney injury (AKI), chronic kidney disease (CKD) and end-stage renal disease (ESRD) represent global health challenges that account for a disproportionately high amount of the total healthcare costs in many countries (Jha et al., 2013;Wang et al., 2016;Hoste et al., 2018). Furthermore, as a result of population aging, the rising incidence of chronic noncommunicable conditions such as obesity, diabetes and hypertension and the increasing complexity of hospital care, the numbers of people affected by AKI and CKD/ESRD are increasing worldwide (Jha et al., 2013;Wang et al., 2016;Hoste et al., 2018). Clinical and population-based studies over the past two decades have revealed that acute and chronic loss of kidney function are associated with remarkable increases in the risk for death and cardiovascular events and reduced health-related quality of life compared to preserved kidney function (Wang et al., 2016;Lv and Zhang, 2019;See et al., 2019). These epidemiological trends have highlighted the urgent need for new and more specific therapies to target kidney disease.is the participation of inflammation and elements of the immune system in virtually all forms of renal and cardiovascular disease (Swaminathan and Shah, 2011;Kurts et al., 2013;Rabb et al., 2016;Sarnak et al., 2019). Specifically, local and systemic mediators of inflammatory response are now known to be triggered by cell stress pathways or cell death mechanisms within the kidney as well as by endogenous and e... |
| ISSN | 16639812 |
| DOI | 10.3389/fphar.2020.00038 |
| Volume Number | 11 |
| Journal | Frontiers in Pharmacology |
| Language | English |
| Publisher Date | 2020-02-06 |
| Access Restriction | Open |
| Subject Keyword | Klotho Acute Kidney Injury Kidney disease Inflammation Interstitial fibrosis Therapeutic targets Alkaline phospatase Sepsis Hepcidin (HAMP) Myricetin Microbiome Chronic Kidney Disease Regulatory T cell (T reg) Interleukin 17 (IL-17A) End-stage renal desease Diabetic nephropathy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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