NDLI: Pharmacological Interventions for REM Sleep Behavior Disorder in Parkinson's Disease: A Systematic Review

Content Provider	frontiers
Author	Yan, Junqiang Liu, Anran Huang, Jiarui Wu, Jiannan Shen, Ruile Ma, Hongxia Yang, Jianxue
Abstract	To review the therapeutic effects of drugs on REM sleep behaviour disorder (RBD) in Parkinson's disease (PD) by searching the MEDLINE/PubMed, Embase, Cochrane and CBM databases. According to the inclusion and exclusion criteria, studies were included after excluding duplicate data. We studied the improvement of RBD in patients with Parkinson's disease (PD-RBD) to evaluate by polysomnography the safety and efficacy of pharmacological intervention. This systematic review mainly describes the drugs that can be used to treat PD-RBD patients. THe studies have shown that melatonin can be used as the first-line drug for PD-RBD, and clonazepam provides significant improvement on PD-RBD. Studies have shown that rotigotine can be used as an alternative drug. However, further large-scale clinical trial studies are still needed to provide the best guidelines for the pharmacological treatment of PD-RBD.
ISSN	16634365
DOI	10.3389/fnagi.2021.709878
Volume Number	13
Journal	Frontiers in Aging Neuroscience
Language	English
Publisher Date	2021-08-13
Access Restriction	Open
Subject Keyword	Sleep Rapid eye movement Drugs Parkinson's disease Systematic review Systematic review, Sleep Parkinson's disease, rapid eye movement, drugs
Content Type	Text
Resource Type	Article
Subject	Aging Cognitive Neuroscience

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Pharmacological Interventions for REM Sleep Behavior Disorder in Parkinson's Disease: A Systematic Review