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| Content Provider | frontiers |
|---|---|
| Author | Yan, Junqiang Liu, Anran Huang, Jiarui Wu, Jiannan Shen, Ruile Ma, Hongxia Yang, Jianxue |
| Abstract | To review the therapeutic effects of drugs on REM sleep behaviour disorder (RBD) in Parkinson's disease (PD) by searching the MEDLINE/PubMed, Embase, Cochrane and CBM databases. According to the inclusion and exclusion criteria, studies were included after excluding duplicate data. We studied the improvement of RBD in patients with Parkinson's disease (PD-RBD) to evaluate by polysomnography the safety and efficacy of pharmacological intervention. This systematic review mainly describes the drugs that can be used to treat PD-RBD patients. THe studies have shown that melatonin can be used as the first-line drug for PD-RBD, and clonazepam provides significant improvement on PD-RBD. Studies have shown that rotigotine can be used as an alternative drug. However, further large-scale clinical trial studies are still needed to provide the best guidelines for the pharmacological treatment of PD-RBD. |
| ISSN | 16634365 |
| DOI | 10.3389/fnagi.2021.709878 |
| Volume Number | 13 |
| Journal | Frontiers in Aging Neuroscience |
| Language | English |
| Publisher Date | 2021-08-13 |
| Access Restriction | Open |
| Subject Keyword | Sleep Rapid eye movement Drugs Parkinson's disease Systematic review Systematic review, Sleep Parkinson's disease, rapid eye movement, drugs |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Cognitive Neuroscience |
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