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| Content Provider | frontiers |
|---|---|
| Author | Giraud, Etienne Rychlik, Ivan Cloeckaert, Axel |
| Abstract | Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. These relationships have been previously reviewed, notably by Beceiro, Tomas and Bou (2013), who described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences. In an excellent review article, Alcade-Rico et al (2016) established that multidrug efflux pumps are « at the cross-road between resistance and virulence of bacterial pathogens ». They decribe how multidrug efflux pumps are involved, besides antibiotic resistance, in many physiological and virulence-related processes controled by complex regulatory networks. A special focus is made on the role of these efflux pumps in bacterial cell-to-cell communication and in bacterial-host interactions.Another example of link between resistance and virulence in Staphylococci is given in a mini review by Qin et al (2016). The authors summarized how the psm-mec locus present in some methici... |
| ISSN | 1664302X |
| DOI | 10.3389/fmicb.2017.00310 |
| Volume Number | 8 |
| Journal | Frontiers in Microbiology |
| Language | English |
| Publisher Date | 2017-03-03 |
| Access Restriction | Open |
| Subject Keyword | Antimicrobial resistance mechanisms Fitness costs Virulence Biofilms Co-Evolution |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology Microbiology (medical) |
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