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| Content Provider | frontiers |
|---|---|
| Author | D’Antongiovanni, Vanessa Fornai, Matteo Pellegrini, Carolina Blandizzi, Corrado Antonioli, Luca |
| Abstract | IntroductionObesity is a complex and multifactorial disease characterized by abnormal fat accumulation resulting from a disequilibrium between energy intake and its consumption (Bluher, 2019). At present, more than one-third of the world population is classified as obese or overweight, and according to a recent estimation it is expected that by 2030 this value will surpass 50% (Bluher, 2019).Obesity is associated with a condition of low-grade systemic inflammation that seems to be a common root to the onset and progression of several comorbidities, such as type-2 diabetes mellitus (T2DM), cardiovascular diseases (CVDs) and cognitive impairment (Jarolimova et al., 2013). In parallel, there is evidence that obese patients often complain of chronic gastrointestinal (GI) disturbances, including gastroesophageal reflux, diarrhea and constipation, undermining their quality of life (Camilleri et al., 2017; D'Antongiovanni et al., 2020a). Preclinical studies on mice fed with high-fat diet (HFD) have shown that the adipocytes and adipose tissue-associated macrophages release a plethora of inflammatory mediators, including interleukin (IL)-1, IL-6, tumor necrosis factor (TNF) and monocyte chemoattractant protein-1, leading to a condition of systemic inflammation and oxidative stress (Ellulu et al., 2017). The chronicization of this inflammatory condition then affects the homeostatic mechanisms, and thereby the physiological functions, of several organs, leading to the development of... |
| ISSN | 16639812 |
| DOI | 10.3389/fphar.2020.621955 |
| Volume Number | 11 |
| Journal | Frontiers in Pharmacology |
| Language | English |
| Publisher Date | 2021-01-18 |
| Access Restriction | Open |
| Subject Keyword | Adenosine Cardiovascular diseas Cognitive impairment Gastrointestinal dysfunction Adenosine receptors Obesity Adipogenesis and lipogenesis Diabete mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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