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| Content Provider | frontiers |
|---|---|
| Author | Qin, Xiao-Ping Lu, Qi-Ji Yang, Cheng-Huizi Wang, Jue Chen, Jian-Fan Liu, Kan Chen, Xin Zhou, Jing Pan, Yu-Hang Li, Yong-Hong Ren, Shan-Cheng Liu, Jiu-Min Liu, Wei-Peng Qian, Hui-Jun Yi, Xian-Lin Lai, Cai-Yong Qu, Li-Jun Gao, Xin Xu, Yu-Sheng Chen, Zheng Zhuo, Yu-Min |
| Abstract | Background: This study determined the predictive value of CRMP4 promoter methylation in the prostate tissues collected by core needle biopsies for a postoperative upgrade in GS to ≥8 . Method: The pathologic factors correlated with the postoperative GS upgrade to ≥8 were analyzed by logistic regression. The cut-off value for CRMP4 promoter methylation in the prostate tissues collected by core needle biopsy was estimated from the ROC curve in patients with a postoperative GS upgrade to ≥8. Result: Multivariate logistic regression showed that prostate volume, number of positive cores, and CRMP4 promoter methylation were predictive factors for a GS upgrade to ≥8 (OR: 0.94, 95% CI: 0.91-0.98, P=0.003; OR: 3.16, 95% CI: 1.81-5.53, P18.00%, the low-risk PCa patients were more likely to escalate to high-risk patients. The predictive sensitivity and specificity were 86.9% and 98.8%, respectively. The area under the ROC curve (AUC) was 0.929 (P18.0% than in patients with CRMP4 methylation ≤18.0% . Conclusion: A CRMP4 promoter methylation rate >18.00% in prostate cancer tissues indicated that patients were more likely to escalate from low-to-high risk after undergoing a RP. In addition, the seminal vesicle invasion rate based on postoperative pathology, positive resection margin rate, positive lymph node involvement rate, BCR, clinical progression rate, and cancer-specific (CS) death rate were higher in patients with a postoperative GS rate to ≥8 than in patients without an upgrade. The BCR-free survival, progression-free survival, and CSS were worse in patients with CRMP4 methylation >18.0% than in patients with CRMP4 methylation ≤18.0%. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2022.840950 |
| Volume Number | 12 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2022-03-10 |
| Access Restriction | Open |
| Subject Keyword | Pelvic lymph node dissection Prostate cancer Gleason score upgrade CRMP4 promoter methylation Biochemical Recurrence |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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