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| Content Provider | frontiers |
|---|---|
| Author | Ott, Kerstin Heikkinen, Taneli Lehtimäki, Kimmo K. Paldanius, Kaisa Puoliväli, Jukka Pussinen, Raimo Andriambeloson, Emile Huyard, Bertrand Wagner, Stéphanie Schnack, Cathrin Wahler, Anke von Einem, Bjoern von Arnim, Christine A. F. Burmeister, Yvonne Weyer, Kathrin Seilheimer, Bernd |
| Description | IntroductionCognitive impairment associated with old age or various brain disorders may be very disabling for affected individuals, placing their carers and public health services under considerable stress. The standard-of-care drugs produce only transient improvement of cognitive impairment in older people, so the search for novel, safe and effective therapeutics that would help to reverse or delay cognitive impairment is warranted. Repurposing pharmacological therapies with well-established safety record for additional indications is a promising recent trend in drug development. Vertigoheel (VH-04), a multicomponent drug made of Ambra grisea, Anamirta cocculus L., Conium maculatum, and Petroleum rectificatum, has been successfully used for several decades in the treatment of vertigo. Here, we investigated effects of VH-04 on cognitive performance in standard behavioral tests assessing different types of memory and explored cellular and molecular underpinnings of VH-04’s biological activity.MethodsIn the majority of behavioral experiments, namely in the spontaneous and rewarded alternation tests, passive avoidance test, contextual/cued fear conditioning, and social transmission of food preference, we examined the ability of single and repeated intraperitoneal administrations of VH-04 to improve cognitive parameters of mice and rats disrupted by the application of the muscarinic antagonist scopolamine. In addition, we also assessed how VH-04 affected novel object recogniti... |
| Abstract | Cognitive impairment associated with old age or various brain disorders may be very disabling for affected individuals, placing their carers and public health services under considerable stress. The standard-of-care drugs produce only transient improvement of cognitive impairment in older people, so the search for novel, safe and effective therapeutics that would help to reverse or delay cognitive impairment is warranted. Repurposing pharmacological therapies with well-established safety record for additional indications is a promising recent trend in drug development. Vertigoheel (VH-04), a multicomponent drug made of Ambra grisea, Anamirta cocculus L., Conium maculatum, and Petroleum rectificatum, has been successfully used for several decades in the treatment of vertigo. Here, we report effects of single and repeated administrations of VH-04 on cognitive performance of mice and rats in several standard behavioral tests assessing different types of memory. We show that administration of VH-04 positively influenced visual recognition memory in the novel object recognition test and alleviated the impairments in spatial working memory and olfactory memory caused by the muscarinic antagonist scopolamine in the spontaneous alternation and social transmission of food preference tests. In addition, VH-04 improved retention of the spatial orientation memory of old rats in the Morris water maze. In contrast, VH-04 did not have significant effects on scopolamine-induced impairments in tests of fear-aggravated memory or rewarded alternation. Experiments in vitro showed that VH-04 stimulated neurite growth and possibly reversed the age-dependent decrease in hippocampal synaptophysin mRNA expression, which implies that VH-04 may preserve synaptic integrity in the aging brain. Our findings allow a cautious conclusion that in addition to its ability to alleviate manifestations of vertigo, VH-04 may be also used as a cognitive enhancer. |
| ISSN | 1662453X |
| DOI | 10.3389/fnins.2023.1183023 |
| Volume Number | 17 |
| Journal | Frontiers in Neuroscience |
| Language | English |
| Publisher Date | 2023-05-31 |
| Access Restriction | Open |
| Subject Keyword | Visual recognition memory Neurite length Vertigoheel Multicomponent drug Olfactory memory Spatial working memory Spatial orientation memory Forgetfulness |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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