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| Content Provider | frontiers |
|---|---|
| Author | Gao, Fei Yin, Jianhui Chen, Yan Guo, Changyong Hu, Honggang Su, Jiacan |
| Abstract | The past decade has become an important strategy in precision medicine for the targeted therapy of many diseases, expecially various types of cancers. As a promising targeted element, nucleic acid aptamers are single-stranded functional oligonucleotides which have specific abilities to bind with various target molecules ranging from small molecules to entire organisms. They are often named ‘chemical antibody’ and have aroused extensive interest in diverse clinical research on account of their advantages, such as considerable biostability, versatile chemical modification, low immuno-genicity and quick tissue penetration. Thus, aptamer-embedded drug delivery systems offer an un-precedented opportunity in bioanalysis and biomedicine. In this short review, we endeavor to dis-cuss the recent advances in aptamer-based targeted drug delivery platform for cancer therapy. Some perspectives on the advantages, challenges and opportunities are also presented. |
| ISSN | 22964185 |
| DOI | 10.3389/fbioe.2022.972933 |
| Volume Number | 10 |
| Journal | Frontiers in Bioengineering and Biotechnology |
| Language | English |
| Publisher Date | 2022-08-16 |
| Access Restriction | Open |
| Subject Keyword | Aptamer-drug conjugates (ApDCs) Aptamer-based nanomaterial system Cancer therapy Aptamers Targeted Drug Delivery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Histology Bioengineering Biomedical Engineering Biotechnology |
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