NDLI: Genome-wide association study for grain yield and component traits in bread wheat (Triticum aestivum L.)

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Year: 2023 Month: August Volume: 14

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Mining candidate genes for rice cadmium accumulation in the shoot through a genome-wide association study and transcriptomic analysis

Prenatal and postnatal diagnosis of Phelan–McDermid syndrome: A report of 21 cases from a medical center and review of the literature

Determination of a prediction model for therapeutic response and prognosis based on chemokine signaling-related genes in stage I–III lung squamous cell carcinoma

Peroxidase is a novel potential marker in glioblastoma through bioinformatics method and experimental validation

Exploring and expanding the phenotype and genotype diversity in seven Chinese families with spondylo-epi-metaphyseal dysplasia

Maternal Xp22.31 copy-number variations detected in non-invasive prenatal screening effectively guide the prenatal diagnosis of X-linked ichthyosis

Insufficiency in functional genomics studies, data, and applications: A case study of bio-prospecting research in ruminant microbiome

Molecular mediators of the association between child obesity and mental health

Construction and verification of a novel hypoxia-related lncRNA signature related with survival outcomes and immune microenvironment of bladder urothelial carcinoma by weighted gene co-expression network analysis

Cuproptosis scoring model predicts overall survival and assists in immunotherapeutic decision making in pancreatic carcinoma

A Prognostic Ferroptosis-Related lncRNA Model Associated With Immune Infiltration in Colon Cancer

Identifying hub genes and miRNAs in Crohn’s disease by bioinformatics analysis

Comparative chloroplast genome analyses of 23 species in Swertia L. (Gentianaceae) with implications for its phylogeny

Case report: Analysis of novel compound heterozygous TPP1 variants in a Chinese patient with neuronal ceroid lipofuscinosis type 2

Bioinformatics searching of diagnostic markers and immune infiltration in polycystic ovary syndrome

Epigenetic manipulation to improve mouse SCNT embryonic development

Genomic study of nonsyndromic hearing loss in unaffected individuals: Frequency of pathogenic and likely pathogenic variants in a Brazilian cohort of 2,097 genomes

Stemness analysis in hepatocellular carcinoma identifies an extracellular matrix gene–related signature associated with prognosis and therapy response

Classification and biomarker gene selection of pyroptosis-related gene expression in psoriasis using a random forest algorithm

Clinical and Genetic Analysis of a Patient With Coexisting 17a-Hydroxylase/17,20-Lyase Deficiency and Moyamoya Disease

Temporal sampling and network analysis reveal rapid population turnover and dynamic migration pattern in overwintering regions of a cosmopolitan pest

Genetic Characteristics and Variation Spectrum of USH2A-Related Retinitis Pigmentosa and Usher Syndrome

Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells

The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma

Depression in systemic lupus erythematosus: Modifiable or inheritable? a two-sample mendelian randomization study

Pan-cancer analysis of the prognosis and immunological role of AKAP12: A potential biomarker for resistance to anti-VEGF inhibitors

Novel Genomic Variants, Atypical Phenotypes and Evidence of a Digenic/Oligogenic Contribution to Disorders/Differences of Sex Development in a Large North African Cohort

A consensus map for quality traits in durum wheat based on genome-wide association studies and detection of ortho-meta QTL across cereal species

Investigation of the transability of dietary small non-coding RNAs to animals

Identification of prognostic biomarkers in the CMTM family genes of human ovarian cancer through bioinformatics analysis and experimental verification

Expression profiles and functions of ferroptosis-related genes in intimal hyperplasia induced by carotid artery ligation in mice

Predicting prognosis and immune responses in hepatocellular carcinoma based on N7-methylguanosine-related long noncoding RNAs

Construction and validation of a necroptosis-related lncRNAs prognosis signature of hepatocellular carcinoma

Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study

Identification of key genes with prognostic value in gastric cancer by bioinformatics analysis

Editorial: Host-microbe interaction and coevolution

miRNA transcriptome and myofiber characteristics of lamb skeletal muscle during hypertrophic growth1

In silico prediction of the animal susceptibility and virtual screening of natural compounds against SARS-CoV-2: Molecular dynamics simulation based analysis

Non-canonical DNA/RNA structures associated with the pathogenesis of Fragile X-associated tremor/ataxia syndrome and Fragile X syndrome

Establishment of a prognostic ferroptosis- and immune-related long noncoding RNAs profile in kidney renal clear cell carcinoma

Fine-scale genetic structure and wolbachia infection of aedes albopictus (Diptera: Culicidae) in Nanjing city, China

Prognostic and immune-related value of complement C1Q (C1QA, C1QB, and C1QC) in skin cutaneous melanoma

Genetic diversity analysis and development of molecular markers for the identification of largemouth bass (Micropterus salmoides L.) based on whole-genome re-sequencing

Insight of vitellogenesis patterns: A comparative analysis of the differences between the primary and secondary vitellogenesis period in the ovary, hepatopancreas, and muscle of mud crab, scylla paramamosain

A pyroptosis-related gene signature for prognosis and immune microenvironment of pancreatic cancer

Prognostic and immunological role of SERPINH1 in pan-cancer

Hierarchical identification of a transcriptional panel for the histological diagnosis of lung neuroendocrine tumors

Exploring the mechanism of YangXue QingNao Wan based on network pharmacology in the treatment of Alzheimer’s disease

Identification of N7-methylguanosine-related IncRNA signature as a potential predictive biomarker for colon adenocarcinoma

Identification of lncRNA biomarkers in hepatocellular carcinoma by comprehensive analysis of the lncRNA-mediated ceRNA network

Case report: Cystic hygroma accompanied with campomelic dysplasia in the first trimester caused by haploinsufficiency with SOX9 deletion

Diagnostic and prognostic value of m5C regulatory genes in hepatocellular carcinoma

Implementation of a biochemical, clinical, and genetic screening programme for familial hypercholesterolemia in 26 centres in Spain: The ARIAN study

Analyzing network diversity of cell–cell interactions in COVID-19 using single-cell transcriptomics

A novel prognostic signature based on cuproptosis-related lncRNA mining in colorectal cancer

Genomic signatures of artificial selection in fecundity of Pacific white shrimp, Penaeus vannamei

Phenotype-Genotype analysis of caucasian patients with high risk of osteoarthritis

FGF/FGFR-related lncRNAs based classification predicts prognosis and guides therapy in gastric cancer

Experimental verification and validation of immune biomarkers based on chromatin regulators in ischemic stroke

Corrigendum: Re-expression of tafazzin isoforms in TAZ-deficient C6 glioma cells restores cardiolipin composition but not proliferation rate and alterations in gene expression

Organization of the mitochondrial genome of Ramulus irregulatiter dentatus (Phasmatidae: Phasmatidae)

GNB3 c.825c>T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccine

CENP-A is a potential prognostic biomarker and correlated with immune infiltration levels in glioma patients

CDK2AP1 influences immune infiltrates and serves as a prognostic indicator for hepatocellular carcinoma

Identification of hub genes related to CD4+ memory T cell infiltration with gene co-expression network predicts prognosis and immunotherapy effect in colon adenocarcinoma

Genotypic and phenotypic characteristics of 12 chinese children with glycogen storage diseases

A comprehensive analysis and validation of cuproptosis-associated genes across cancers: Overall survival, the tumor microenvironment, stemness scores, and drug sensitivity

Identification of a 5-lncRNA-Based Signature for Immune Characteristics and Prognosis of Lung Squamous Cell Carcinoma and Verification of the Function of lncRNA SPATA41

Serum differential proteomic profiling of patients with isolated methylmalonic acidemia by iTRAQ

A p53 transcriptional signature in primary and metastatic cancers derived using machine learning

Locating a novel autosomal recessive genetic variant in the cattle glucokinase gene using only WGS data from three cases and six carriers

An integrative analysis of DNA methylation and gene expression to predict lung adenocarcinoma prognosis

Identification of an immune-related gene prognostic index for predicting survival and immunotherapy efficacy in papillary renal cell carcinoma

An integrated pan-cancer analysis of PSAT1: A potential biomarker for survival and immunotherapy

Multisite assessment of the impact of cell-free DNA-based screening for rare autosomal aneuploidies on pregnancy management and outcomes

Characterization of tumor immune microenvironment and cancer therapy for head and neck squamous cell carcinoma through identification of a genomic instability-related lncRNA prognostic signature

Integrated transcriptome and hormone analyses provide insights into silver thiosulfate-induced “maleness” responses in the floral sex differentiation of pumpkin (Cucurbita moschata D.)

Construction and validation of a novel coagulation-related 7-gene prognostic signature for gastric cancer

TRIB3 promoter 33 bp VNTR is associated with the risk of cerebrovascular disease in type 2 diabetic patients

miR-22-3p as a potential biomarker for coronary artery disease based on integrated bioinformatics analysis

Identifying novel genetic loci associated with polycystic ovary syndrome based on its shared genetic architecture with type 2 diabetes

Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology

Mechanisms governing the accessibility of DNA damage proteins to constitutive heterochromatin

Pancancer analysis of a potential gene mutation model in the prediction of immunotherapy outcomes

Small RNA sequencing reveals sex-related miRNAs in Collichthys lucidus

Ferroptosis-related lncRNAs signature to predict the survival and immune evasion for lung squamous cell carcinoma

Detection of a Cryptic 25 bp Deletion and a 269 Kb Microduplication by Nanopore Sequencing in a Seemingly Balanced Translocation Involving the LMLN and LOC105378102 Genes

Identification of potential models for predicting progestin insensitivity in patients with endometrial atypical hyperplasia and endometrioid endometrial cancer based on ATAC-Seq and RNA-Seq integrated analysis

The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media

Case Report: Novel compound heterozygous variants in CHRNA1 gene leading to lethal multiple pterygium syndrome: A case report

Deciphering inhibitory mechanism of coronavirus replication through host miRNAs-RNA-dependent RNA polymerase interactome

Comparative transcriptome analysis of brain and gonad reveals reproduction-related miRNAs in the giant prawn, Macrobrachium rosenbergii

Identification of a chromatin regulator signature and potential prognostic ability for adrenocortical carcinoma

Genome-wide association study for grain yield and component traits in bread wheat (Triticum aestivum L.)

A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration

Use of DNA pools of a reference population for genomic selection of a binary trait in Atlantic salmon

Exploring the optimal strategy of imputation from SNP array to whole-genome sequencing data in farm animals

Expression of T cell-related lncRNAs in multiple sclerosis

Editorial: SARS-CoV-2: From Genetic Variability to Vaccine Design

Bioinformatic workflow fragment discovery leveraging the social-aware knowledge graph

LncRNA RP11-59J16.2 aggravates apoptosis and increases tau phosphorylation by targeting MCM2 in AD

Cross-talk between the cytokinin, auxin, and gibberellin regulatory networks in determining parthenocarpy in cucumber

Whole Genome Sequencing and Morphological Trait-Based Evaluation of UPOV Option 2 for DUS Testing in Rice

Transcriptomic and immunologic implications of the epithelial–mesenchymal transition model reveal a novel role of SFTA2 in prognosis of non-small-cell lung carcinoma

Construction of a novel Wheat 55 K SNP array-derived genetic map and its utilization in QTL mapping for grain yield and quality related traits

The worldwide spread of Aedes albopictus: New insights from mitogenomes

Barriers to hydroxyurea use from the perspectives of providers, individuals with sickle cell disease, and families: Report from a U.S. regional collaborative

RUNX regulated immune-associated genes predicts prognosis in breast cancer

TaNAC020 homoeologous genes are associated with higher thousand kernel weight and kernel length in Chinese wheat

Fine-scale differences in eukaryotic communities inside and outside salmon aquaculture cages revealed by eDNA metabarcoding

Cold adaptation strategies in plants—An emerging role of epigenetics and antifreeze proteins to engineer cold resilient plants

Genetic diversity and population structure of Tongcheng pigs in China using whole-genome SNP chip

Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in Alzheimer’s disease with qPCR validation

Comprehensive exploration of tumor immune microenvironment feature and therapeutic response in colorectal cancer based on a novel immune-related long non-coding RNA prognostic signature

A novel necroptosis-related lncRNA signature for predicting prognosis and immune response of colon cancer

Twelve exonic variants in the SLC12A1 and CLCNKB genes alter RNA splicing in a minigene assay

A novel prognostic and therapeutic target biomarker based on necroptosis-related gene signature and immune microenvironment infiltration in gastric cancer

Methylation associated with long- or short-term survival in glioblastoma patients from the Nordic phase 3 trial

Comprehensive characterization of pharmacogenes in a Taiwanese Han population

Molecular characterization, clinical relevance and immune feature of m7G regulator genes across 33 cancer types

Case Report: Identification of a novel CASK missense variant in a Chinese family with MICPCH

Exonization of a deep intronic long interspersed nuclear element in Becker muscular dystrophy

Intergeneric hybridization of two stickleback species leads to introgression of membrane-associated genes and invasive TE expansion

Identification of the pyroptosis-related prognostic gene signature and characterization of tumor microenvironment infiltration in triple-negative breast cancer

Case Report: Three novel pathogenic ABCC2 mutations identified in two patients with Dubin–Johnson syndrome

Case Report: Clinical characteristics and genetic analysis of two patients with hereditary hemorrhagic telangiectasia

The clonal expression genes associated with poor prognosis of liver cancer

Establishment of prognostic model for postoperative patients with metaplastic breast cancer: Based on a retrospective large data analysis and Chinese multicenter study

Repression of enhancer RNA PHLDA1 promotes tumorigenesis and progression of Ewing sarcoma via decreasing infiltrating T‐lymphocytes: A bioinformatic analysis

The De Novo Genome Assembly of Olea europaea subsp. cuspidate, a Widely Distributed Olive Close Relative

m5C Regulator-mediated methylation modification clusters contribute to the immune microenvironment regulation of multiple myeloma

NcRNA-mediated upregulation of CAMK2N1 is associated with poor prognosis and tumor immune infiltration of gastric cancer

Decoding regulatory associations of G-quadruplex with epigenetic and transcriptomic functional components

Development and validation of a novel endoplasmic reticulum stress-related lncRNA prognostic signature and candidate drugs in breast cancer

Editorial: Progress in understanding the immunogenetic basis of disease susceptibility and outcomes

Roles and regulation of histone acetylation in hepatocellular carcinoma

Identification and validation of a novel cellular senescence-related lncRNA prognostic signature for predicting immunotherapy response in stomach adenocarcinoma

CircPUM1 Knockdown Confers Radiosensitivity in Oral Squamous Cell Carcinoma by Regulating the miR-580/STAT3 Pathway

Characterization of chromatin regulators in hepatocellular carcinoma to guide clinical therapy

A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer

Case Report: Diverse phenotypes of congenital poikiloderma associated with FAM111B mutations in codon 628: A case report and literature review

Contrasting population differentiation in two sympatric Triplophysa loaches on the Qinghai–Tibet Plateau

Incidence of Down Syndrome by maternal age in Chinese population

Genotyping-by-sequencing of Canada’s apple biodiversity collection

Network analysis of hepatocellular carcinoma liquid biopsies augmented by single-cell sequencing data

Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma

XBP1 impacts lung adenocarcinoma progression by promoting plasma cell adaptation to the tumor microenvironment

Applicability of single-step genomic evaluation with a random regression model for reproductive traits in turkeys (Meleagris gallopavo)

Corrigendum: A potential indicator ARRDC2 has feasibility to evaluate prognosis and immune microenvironment in ovarian cancer

Geometric complement heterogeneous information and random forest for predicting lncRNA-disease associations

Innovation in the Breeding of Common Bean Through a Combined Approach of in vitro Regeneration and Machine Learning Algorithms

Molecular basis of epigenetic regulation in cancer diagnosis and treatment

Elevated insulin-like growth factor 2 mRNA binding protein 1 levels predict a poor prognosis in patients with breast carcinoma using an integrated multi-omics data analysis

Nine-gene signature and nomogram for predicting survival in patients with head and neck squamous cell carcinoma

Editorial: Novel approaches and concepts of biomarker discovery for cancer

Expression of lactate-related signatures correlates with immunosuppressive microenvironment and prognostic prediction in ewing sarcoma

Evolutionary selection identifies critical immune-relevant genes in lung cancer subtypes

Structural and functional insights into the candidate genes associated with different developmental stages of flag leaf in bread wheat (Triticum aestivum L.)

A mendelian randomization study with populations of European ancestry rules out a causal relationship between inflammatory bowel disease and colorectal cancer

Knockdown of Circ_0037658 Alleviates IL-1β-Induced Osteoarthritis Progression by Serving as a Sponge of miR-665 to Regulate ADAMTS5

Characterization of aging cancer-associated fibroblasts draws implications in prognosis and immunotherapy response in low-grade gliomas

Genome-wide association mapping for root traits associated with frost tolerance in faba beans using KASP-SNP markers

Identification of Four Biomarkers of Human Skin Aging by Comprehensive Single Cell Transcriptome, Transcriptome, and Proteomics

DDX59-AS1 is a prognostic biomarker and correlated with immune infiltrates in OSCC

CircSMARCA5: A key circular RNA in various human diseases

Investigating circulating miRNA in transition dairy cows: What miRNAomics tells about metabolic adaptation

Comprehensive analysis of nine m7G-related lncRNAs as prognosis factors in tumor immune microenvironment of hepatocellular carcinoma and experimental validation

The role and mechanism of histone lactylation in health and diseases

Differential expression of HAVCR2 gene in pan-cancer: A potential biomarker for survival and immunotherapy

Editorial: Reproductive genomics

A prognostic exosome-related LncRNA risk model correlates with the immune microenvironment in liver cancer

Mutational signatures representative transcriptomic perturbations in hepatocellular carcinoma

Early-Life Exposure of Pigs to Topsoil Alters miRNA and mRNA Expression in Peripheral Blood Mononuclear Cells

An integrative analysis revealing POLD2 as a tumor suppressive immune protein and prognostic biomarker in pan-cancer

Construction of a prognostic model related to copper dependence in breast cancer by single-cell sequencing analysis

Editorial: The genetics of inherited retinal diseases in understudied ethnic groups: Novel associations, challenges, and perspectives

Research progress of exosomes in orthopedics

Genetic and clinical phenotypic analysis of carney complex with external auditory canal myxoma

Comprehending the evolution of gene editing platforms for crop trait improvement

Knowledge structure and emerging trends in the application of deep learning in genetics research: A bibliometric analysis [2000–2021]

Transparent human – (non-) transparent technology? The Janus-faced call for transparency in AI-based health care technologies

Comprehensive genome sequence analysis of the devastating tobacco bacterial phytopathogen Ralstonia solanacearum strain FJ1003

Circulating adipokine levels and preeclampsia: A bidirectional Mendelian randomization study

Case Report: Long-term follow-up of desert hedgehog variant caused 46, XY gonadal dysgenesis with multiple complications in a Chinese child

Genome-wide identification, structural analysis and expression profiles of short internodes related sequence gene family in quinoa

Cuproptosis-related lncRNA: Prediction of prognosis and subtype determination in clear cell renal cell carcinoma

Beyond race: Recruitment of diverse participants in clinical genomics research for rare disease

Dynamic transcriptome analysis suggests the key genes regulating seed development and filling in Tartary buckwheat (Fagopyrum tataricum Garetn.)

Predict potential miRNA-disease associations based on bounded nuclear norm regularization

Prospective study of pediatric patients presenting with idiopathic infantile nystagmus—Management and molecular diagnostics

Identification and characterization of a novel homozygous splice site variant of PATL2 causing female infertility due to oocyte germinal vesicle arrest

Significance of ZEB2 in the immune microenvironment of colon cancer

A Novel Approach: Combining Prognostic Models and Network Pharmacology to Target Breast Cancer Necroptosis-Associated Genes

Predicting AURKA as a novel therapeutic target for NPC: A comprehensive analysis based on bioinformatics and validation

Clinical Utility of Medical Exome Sequencing: Expanded Carrier Screening for Patients Seeking Assisted Reproductive Technology in China

Genome-wide association study identified genes associated with ammonia nitrogen tolerance in Litopenaeus vannamei

Aspergillus oryzae accelerates the conversion of ergosterol to ergosterol peroxide by efficiently utilizing cholesterol

Development and validation of immune-based biomarkers and deep learning models for Alzheimer’s disease

Integrated Analysis Reveals the Potential Significance of HDAC Family Genes in Lung Adenocarcinoma

Clustering CITE-seq data with a canonical correlation-based deep learning method

Efficacy of Long-Term Treatment of Autosomal Recessive Hypercholesterolemia With Lomitapide: A Subanalysis of the Pan-European Lomitapide Study

Comprehensive analysis for clarifying transcriptomics landscapes of spread through air spaces in lung adenocarcinoma

Differential gene expression and identification of growth-related genes in the pituitary gland of South African goats

AttnTAP: A Dual-input Framework Incorporating the Attention Mechanism for Accurately Predicting TCR-peptide Binding

Genetic analysis of a bronze age individual from Ulug-depe (Turkmenistan)

Genetic evaluation of Jatropha backcross hybrid clones (BC4F1) for yield and oil quality

Prenatal phenotype analysis and mutation identification of a fetus with meckel gruber syndrome

SNPMap—An integrated visual SNP interpretation tool

Identification of QTLs for rice grain size and weight by high-throughput SNP markers in the IR64 x Sadri population

EV duty vehicles: Features and functions of ciliary extracellular vesicles

Comprehensive analysis of the prognostic and immunotherapeutic implications of STAT family members in human colorectal cancer

Inflammatory bowel disease and celiac disease: A bidirectional Mendelian randomization study

Insights to maternal regulation of the paternal genome in mammalian livestock embryos: A mini-review

DNA methylation as a mediator of genetic and environmental influences on Parkinson’s disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome

Prognostic microRNAs associated with phosphoserine aminotransferase 1 in gastric cancer as markers of bone metastasis

Genetic mapping of QTLs for drought tolerance in chickpea (Cicer arietinum L.)

Phosphatidylinositol glycan anchor biosynthesis, class C is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma

Low circulating PCSK9 levels in LPL homozygous children with chylomicronemia syndrome in a syrian refugee family in Lebanon

Identification of a prognostic model based on costimulatory molecule-related subtypes and characterization of tumor microenvironment infiltration in acute myeloid leukemia

Prognostic and immunological role of cuproptosis-related protein FDX1 in pan-cancer

Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes

Multiethnic polygenic risk prediction in diverse populations through transfer learning

Genome-Wide Analysis and Evolutionary Perspective of the Cytokinin Dehydrogenase Gene Family in Wheat (Triticum aestivum L.)

Study the forest, not only the trees: Environmental exposures, not genomes, generate most health disparities

Expression profiles analysis identifies specific interferon-stimulated signatures as potential diagnostic and predictive indicators of JAK2V617F+ myelofibrosis

Genetic analysis of morphological traits in spring wheat from the Northeast of China by a genome-wide association study

Variants rs2200733 and rs6843082 Show Different Associations in Asian and Non-Asian Populations With Ischemic Stroke

Steroid implants for the induction of vitellogenesis in feminized European silver eels (Anguilla anguilla L.)

Integrating cell cycle score for precise risk stratification in ovarian cancer

A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery

DNA methylation affects freezing tolerance in winter rapeseed by mediating the expression of genes related to JA and CK pathways

STAT3 and p63 in the Regulation of Cancer Stemness

Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort

Ferroptosis-related gene expression in the pathogenesis of preeclampsia

MiR-33a targets FOSL1 and EN2 as a clinical prognostic marker for sarcopenia by glioma

The overexpression of GPX8 is correlated with poor prognosis in GBM patients

Editorial: Genetic diversity and selection signatures in composite breeds

Integrated pan-cancer analysis of CSMD2 as a potential prognostic, diagnostic, and immune biomarker

Exploration of shared gene signature with development of pre-eclampsia and cervical cancer

Circulating miRNAs in maternal plasma as potential biomarkers of early pregnancy in sheep

Integrated risk scores from N6-methyladenosine-related lncRNAs are potential biomarkers for predicting the overall survival of bladder cancer patients

Targeted re-sequencing on 1p22 among non-syndromic orofacial clefts from Han Chinese population

Pan-Cancer Analysis of the Oncogenic and Immunological Role of Solute Carrier Family 6 Member 8 (SLC6A8)

Case Report: Bi-allelic missense variant in the desmocollin 3 gene causes hypotrichosis and recurrent skin vesicles

Genome-wide association study, haplotype analysis, and genomic prediction reveal the genetic basis of yield-related traits in soybean (Glycine max L.)

Editorial: Biomedical image or genomic data characterization and radiogenomic/image-omics

Corrigendum: Developing an immune-related signature for predicting survival rate and the response to immune checkpoint inhibitors in patients with glioma

Oncogenic signaling pathway dysregulation landscape reveals the role of pathways at multiple omics levels in pan-cancer

eQTL analysis of laying hens divergently selected for feather pecking identifies KLF14 as a potential key regulator for this behavioral disorder

Identification of Nitrogen Starvation-Responsive miRNAs to Reveal the miRNA-Mediated Regulatory Network in Betula luminifera

Molecular characteristics of immunocytes infiltration in primary central nervous system lymphoma

The rise of hierarchy and modularity in biological networks explained by Empedocles’ double tale ∼2,400 years before Darwin and systems biology

Construction, bioinformatics analysis, and validation of competitive endogenous RNA networks in ulcerative colitis

Computational Analysis of Deleterious SNPs in NRAS to Assess Their Potential Correlation With Carcinogenesis

Juvenile-onset PSAT1-related neuropathy: A milder phenotype of serine deficiency disorder

KGDCMI: A New Approach for Predicting circRNA–miRNA Interactions From Multi-Source Information Extraction and Deep Learning

Genetic parameters for residual feed intake, methane emissions, and body composition in New Zealand maternal sheep

Spatiotemporal characteristics of the pharyngeal teeth in interspecific distant hybrids of cyprinid fish: Phylogeny and expression of the initiation marker genes

Integrated analysis of necroptosis-related lncRNAs for prognosis and immunotherapy of patients with pancreatic adenocarcinoma

Case report: Disease phenotype associated with simultaneous biallelic mutations in ABCA4 and USH2A due to uniparental disomy of chromosome 1

Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development

Clinical characteristics and variant analyses of transient infantile hypertriglyceridemia related to GPD1 gene

Genotype-phenotype correlations of marfan syndrome and related fibrillinopathies: Phenomenon and molecular relevance

Arbutin Protects Retinal Pigment Epithelium Against Oxidative Stress by Modulating SIRT1/FOXO3a/PGC-1α/β Pathway

Comprehensive circular RNA expression profile of lung adenocarcinoma with bone metastasis: Identification of potential biomarkers

Effects of the PLK4 inhibitor Centrinone on the biological behaviors of acute myeloid leukemia cell lines

A homozygous variant in the GPIHBP1 gene in a child with severe hypertriglyceridemia and a systematic literature review

Case Report: Aarskog-scott syndrome caused by FGD1 gene variation: A family study

COVID-19 in pediatrics: Genetic susceptibility

“Democratizing” artificial intelligence in medicine and healthcare: Mapping the uses of an elusive term

A method for identifying moonlighting proteins based on linear discriminant analysis and bagging-SVM

LncRNA DUXAP8 as a prognostic biomarker for various cancers: A meta-analysis and bioinformatics analysis

Whole-exome sequencing expands the roles of novel mutations of organic anion transporting polypeptide, ATP-binding cassette transporter, and receptor genes in intrahepatic cholestasis of pregnancy

Random forests algorithm boosts genetic risk prediction of systemic lupus erythematosus

Case Report: Chinese female patients with a heterozygous pathogenic RPS6KA3 gene variant c.898C>T and distal 22q11.2 microdeletion

Corrigendum: Development and validation of a prognostic nomogram based on DNA methylation-driven genes for patients with ovarian cancer

Using expression quantitative trait loci data and graph-embedded neural networks to uncover genotype–phenotype interactions

A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma

Case report: Multiple gastrointestinal perforations in a rare musculocontractural Ehlers–Danlos syndrome with multiple organ dysfunction

Network pharmacological analysis of active components of Xiaoliu decoction in the treatment of glioblastoma multiforme

Integrated multi-omic data reveal the potential molecular mechanisms of the nutrition and flavor in Liancheng white duck meat

Identifying key genes in CD4+ T cells of systemic lupus erythematosus by integrated bioinformatics analysis

Association of FLG mutation with tumor mutation load and clinical outcomes in patients with gastric cancer

Multi-omics analysis reveals prognostic and therapeutic value of cuproptosis-related lncRNAs in oral squamous cell carcinoma

Integrated analysis of senescence-associated genes in pancreatic ductal adenocarcinoma

Corrigendum: Comprehensive analysis of the transcriptome-wide m6A methylation in mouse pachytene spermatocytes and round spermatids

Effects of ulcerative colitis and Crohn’s disease on neurodegenerative diseases: A Mendelian randomization study

Identification of novel tumor microenvironment-associated genes in gastric cancer based on single-cell RNA-sequencing datasets

Single-cell RNA sequencing analysis to explore immune cell heterogeneity and novel biomarkers for the prognosis of lung adenocarcinoma

Prognosis analysis of necroptosis-related genes in colorectal cancer based on bioinformatic analysis

Linkage QTL Mapping and Genome-Wide Association Study on Resistance in Chickpea to Pythium ultimum

Oculocutaneous albinism and bleeding diathesis due to a novel deletion in the HPS3 gene

Lactate score predicts survival, immune cell infiltration and response to immunotherapy in breast cancer

Comprehensive Analysis of Molecular Subtypes and Hub Genes of Sepsis by Gene Expression Profiles

Identification of Novel Compound Heterozygous Variants of MMP9 in Fetus With Metaphyseal Anadysplasia Type 2

The miR166–mRNA network regulates vascular tissue differentiation in Moso bamboo

Novel genetic associations with five aesthetic facial traits: A genome-wide association study in the Chinese population

Insight into the molecular mechanisms of leaf coloration in Cymbidium ensifolium

Case Report: Heterozygous Germline Variant in EIF6 Additional to Biallelic SBDS Pathogenic Variants in a Patient With Ribosomopathy Shwachman–Diamond Syndrome

ADD1 Single Nucleotide Polymorphisms Are Associated With Essential Hypertension Among Han and Mongolian Population in Inner Mongolia Area

DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review

RNA sequencing and integrative analysis reveal pathways and hub genes associated with TGFβ1 stimulation on prostatic stromal cells

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Genome-wide association study for grain yield and component traits in bread wheat (Triticum aestivum L.)

Content Provider	frontiers
Author	Khan, Hanif Krishnappa, Gopalareddy Kumar, Satish Mishra, Chandra Nath Krishna, Hari Devate, Narayana Bhat Rathan, Nagenahalli Dharmegowda Parkash, Om Yadav, Sonu Singh Srivastava, Puja Biradar, Suma Kumar, Monu Singh, Gyanendra Pratap
Abstract	Genomic regions governing days to heading (DH), grain filling duration (GFD), grain number per spike (GNPS), grain weight per spike (GWPS), plant height (PH), and grain yield (GY) were investigated in a set of 280 diverse bread wheat genotypes. The genome-wide association (GWAS) panel was genotyped using a 35K Axiom Array and phenotyped in five environments. The GWAS analysis showed a total of 27 Bonferroni-corrected marker-trait associations (MTAs) on 15 chromosomes representing all three wheat subgenomes. The GFD showed the highest MTAs (8), followed by GWPS (7), GY (4), GNPS (3), PH (3), and DH (2). Furthermore, 20 MTAs were identified with more than 10% phenotypic variation. A total of five stable MTAs (AX-95024590, AX-94425015, AX-95210025 AX-94539354, and AX-94978133) were identified in more than one environment and associated with the expression of DH, GFD, GNPS, and GY. Similarly, two novel pleiotropic genomic regions with associated MTAs i.e. AX-94978133 (4D) and AX-94539354 (6A) harboring co-localized QTLs governing two or more traits were also identified. In silico analysis revealed that the SNPs were located on important putative candidate genes such as F-box-like domain superfamily, Lateral organ boundaries, LOB, Thioredoxin-like superfamily Glutathione S-transferase, RNA-binding domain superfamily, UDP-glycosyltransferase family, Serine/threonine-protein kinase, Expansin, Patatin, Exocyst complex component Exo70, DUF1618 domain, Protein kinase domain involved in the regulation of grain size, grain number, growth and development, grain filling duration, and abiotic stress tolerance. The identified novel MTAs will be validated to estimate their effects in different genetic backgrounds for subsequent use in marker-assisted selection (MAS).
ISSN	16648021
DOI	10.3389/fgene.2022.982589
Volume Number	13
Journal	Frontiers in Genetics
Language	English
Publisher Date	2022-08-26
Access Restriction	Open
Subject Keyword	Wheat Mapping GWAS Snps Candidate genes
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Medicine Genetics (clinical)

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