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| Content Provider | frontiers |
|---|---|
| Author | Lin, Yangyi Pang, Lingpin Huang, Shian Shen, Jieyan Wu, Weifeng Tang, Fangming Su, Weiqing Zhu, Xiulong Sun, Jingzhi Quan, Ruilin Yang, Tao Han, Huijun He, Jianguo |
| Abstract | Background: Patients with left heart failure (LHF) are often associated with the development of pulmonary hypertension (PH) which leads to an increased risk of death. Recently, the diagnostic standard for PH was changed from mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg to > 20 mmHg. Nonetheless, the effect of borderline PH (mPAP: 21–24 mmHg) on the prognosis of LHF patients is unknown. This study aimed to investigate the relationship between borderline PH and 3-year clinical outcomes in LHF patients. Methods: A retrospective analysis of a prospective cohort study was done for LHF patients who underwent right heart catheterization (RHC) between January 2013 and November 2016. The primary outcome was all-cause mortality, second outcome was rehospitalization. Results: Among 344 patients, 62.5% were identified with a proportion of PH (mPAP ≥25), 10.8% with borderline PH (21-24), and 26.7% with non-PH (≤20), respectively. Multivariable Cox analysis revealed that borderline PH patients had a higher adjusted mortality risk (HR = 3.822; 95% CI: 1.043–13.999; p = 0.043) than non-PH patients. When mPAP was treated as a continuous variable, the hazard ratio for death increased progressively with increasing mPAP starting at 20 mmHg (HR = 1.006; 95% CI: 1.001–1.012). There was no statistically significant difference in adjusted rehospitalization between borderline PH and non-PH (HR = 1.599; 95% CI: 0.833–3.067; p = 0.158). Conclusions: Borderline PH is independently related to increased 3-year mortality in LHF patients. Future research is needed to evaluate whether more close monitoring, and managing with an intensifier improves clinical outcomes in borderline PH caused by LHF. |
| ISSN | 2297055X |
| DOI | 10.3389/fcvm.2022.983803 |
| Volume Number | 9 |
| Journal | Frontiers in Cardiovascular Medicine |
| Language | English |
| Publisher Date | 2022-08-12 |
| Access Restriction | Open |
| Subject Keyword | Mean pulmonary artery pressure (mPAP) Borderline pulmonary hypertension Left heart failure Mortality Right heart catheterization (RHC) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
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