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| Content Provider | frontiers |
|---|---|
| Author | Xiong, Yuyan Yepuri, Gautham Montani, Jean-Pierre Ming, Xiu-Fen Yang, Zhihong |
| Abstract | The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66Shc and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-II on organismal lifespan is not known. In this study, we demonstrate a significant lifespan extension in mice with Arg-II gene deficiency (Arg-II−/−) as compared to wild type (WT) control animals. This effect is more pronounced in the females than in the males. The gender difference is associated with higher Arg-II expression levels in the females than in the males in skin and heart at both young and old age. Ablation of Arg-II gene significantly reduces the aging marker p16INK4a levels in these tissues of old female mice, whereas in the male mice this effect of Arg-II deficiency is weaker. In line with this observation, age-associated increases in S6K1 signaling and p66Shc levels in heart are significantly attenuated in the female Arg-II−/− mice. In the male mice, only p66Shc but not S6K1 signaling is reduced. In summary, our study demonstrates that Arg-II may play an important role in the acceleration of aging in mice. Genetic disruption of Arg-II in mouse extends lifespan predominantly in females, which relates to inhibition of S6K1, p66Shc, and p16INK4a. Thus, Arg-II may represent a promising target to decelerate aging process and extend lifespan as well as to treat age-related diseases. |
| ISSN | 1664042X |
| DOI | 10.3389/fphys.2017.00682 |
| Volume Number | 8 |
| Journal | Frontiers in Physiology |
| Language | English |
| Publisher Date | 2017-09-08 |
| Access Restriction | Open |
| Subject Keyword | S6K1 P66shc Arginase Aging Lifespan MTOR P16INK4a |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) |
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