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| Content Provider | frontiers |
|---|---|
| Author | Manjarrez-Orduño, Nataly Menard, Laurence C. Kansal, Selena Fischer, Paul Kakrecha, Bijal Jiang, Can Cunningham, Mark Greenawalt, Danielle Patel, Vishal Yang, Minghui Golhar, Ryan Carman, Julie A. Lezhnin, Sergey Dai, Hongyue Kayne, Paul S. Suchard, Suzanne J. Bernstein, Steven H. Nadler, Steven G. |
| Abstract | Agents targeting the PD1-PDL1 axis have transformed cancer therapy. Factors that influence clinical response to PD1-PDL1 inhibitors include tumor mutational burden, immune infiltration of the tumor and local PDL1 expression. To identify peripheral correlates of the anti-tumor immune response in the absence of checkpoint blockade, we performed a retrospective study of circulating T cell subpopulations and matched tumor gene expression in melanoma and non-small cell lung carcinoma (NSCLC) patients. Notably, both melanoma and NSCLC patients whose tumors exhibited increased inflammatory gene transcripts presented high CD4+ and CD8+ central memory T cell (CM) to effector T cell (Eff) ratios in blood. Consequently, we evaluated CM/Eff T cell ratios in a second cohort of NSCLC. The data showed that high CM/Eff T cell ratios correlated with increased tumor PDL1 expression. Furthermore, of the 22 patients within this NSCLC cohort who received nivolumab, those with high CM/Eff T cell ratios, had longer progression-free survival (PFS) (median survival: 91 vs. 215 days). These findings show that by providing a window into the state of the immune system, peripheral T cell subpopulations inform about the state of the anti-tumor immune response and identify potential blood biomarkers of clinical response to checkpoint inhibitors in melanoma and NSCLC. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2018.01613 |
| Volume Number | 9 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2018-08-03 |
| Access Restriction | Open |
| Subject Keyword | Melanoma PD1 and PDL1 Checkpoint blockade Lung cancer T cells subpopulations |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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