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| Content Provider | frontiers |
|---|---|
| Author | Hanif, Muhammad Yang, Xiaoda Tinoco, Arthur D. Plażuk, Damian |
| Abstract | Metals not only perform crucial functions in biology, but they are widely used for diagnostic and therapeutic agents. Examples of clinical uses include gadolinium complexes as MRI contrast agents, technetium-99m complexes as imaging agents and platinum-based anticancer agents. DNA targeted platinum drugs are used in more than 50% of cancer treatments either alone or in combination therapy. Despite their huge success in the clinic, they are not devoid of drawbacks including severe side effects due to dose-related toxicity and the emergence of drug resistance. These limitations have inspired the investigation of platinum and non-platinum metal complexes with modes of action different from those of platinum drugs. As a result, the compounds of metals present across the periodic table were designed and developed for a range of diseases from cancer (e.g., Ru, Gd, Ti, Ge, V, and, Ga) to diabetes (V and Cr) to infectious diseases (Ag, Cu, Ru). Each metal has unique features such as redox potentials and ligand exchange kinetics. Therefore, the choice of the metal center and ligand design play a crucial role in the therapeutic effects and the mechanism of action for new agents (Hanif and Hartinger, 2018 |
| ISSN | 22962646 |
| DOI | 10.3389/fchem.2020.00453 |
| Volume Number | 8 |
| Journal | Frontiers in Chemistry |
| Language | English |
| Publisher Date | 2020-05-28 |
| Access Restriction | Open |
| Subject Keyword | Metallodrugs Alzheimer's disease Iridium complexes Anticancer agents Ruthenium complexes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
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