NDLI: Weighted Gene Co-Expression Network Analysis (WGCNA) Reveals the Functions of Syndecan-1 to Regulate Immune Infiltration by Influenced T Cells in Glioma

Please wait, while we are loading the content...

Frontiers in Aerospace Engineering

Frontiers in Aging

Frontiers in Aging Neuroscience

Frontiers in Agronomy

Frontiers in Allergy

Frontiers in Amphibian and Reptile Science

Frontiers in Analytical Science

Frontiers in Anesthesiology

Frontiers in Animal Science

Frontiers in Antennas and Propagation

Frontiers in Antibiotics

Frontiers in Applied Mathematics and Statistics

Frontiers in Aquaculture

Frontiers in Arachnid Science

Frontiers in Artificial Intelligence

Frontiers in Astronomy and Space Sciences

Frontiers in Audiology and Otology

Frontiers in Bacteriology

Frontiers in Batteries and Electrochemistry

Frontiers in Bee Science

Frontiers in Behavioral Economics

Frontiers in Behavioral Neuroscience

Frontiers in Big Data

Frontiers in Bioengineering and Biotechnology

Frontiers in Bioinformatics

Frontiers in Biomaterials Science

Frontiers in Biophysics

Frontiers in Bird Science

Frontiers in Blockchain

Frontiers in Built Environment

Frontiers in Carbon

Frontiers in Cardiovascular Medicine

Frontiers in Catalysis

Frontiers in Cell Death

Frontiers in Cell and Developmental Biology

Frontiers in Cellular Neuroscience

Frontiers in Cellular and Infection Microbiology

Frontiers in Ceramics

Frontiers in Chemical Biology

Frontiers in Chemical Engineering

Frontiers in Chemistry

Frontiers in Child and Adolescent Psychiatry

Frontiers in Climate

Frontiers in Clinical Diabetes and Healthcare

Frontiers in Coatings, Dyes and Interface Engineering

Frontiers in Cognition

Frontiers in Communication

Frontiers in Communications and Networks

Frontiers in Complex Systems

Frontiers in Computational Neuroscience

Frontiers in Computer Science

Frontiers in Conservation Science

Frontiers in Control Engineering

Frontiers in Dementia

Frontiers in Dental Medicine

Frontiers in Digital Health

Frontiers in Digital Humanities

Frontiers in Disaster and Emergency Medicine

Frontiers in Drug Delivery

Frontiers in Drug Discovery

Frontiers in Drug Safety and Regulation

Frontiers in Earth Science

Frontiers in Ecology and Evolution

Frontiers in Education

Frontiers in Electronic Materials

Frontiers in Electronics

Frontiers in Endocrinology

Frontiers in Energy Efficiency

Frontiers in Energy Research

Frontiers in Environmental Archaeology

Frontiers in Environmental Chemistry

Frontiers in Environmental Economics

Frontiers in Environmental Engineering

Frontiers in Environmental Health

Frontiers in Environmental Science

Frontiers in Epidemiology

Frontiers in Epigenetics and Epigenomics

Frontiers in Ethology

Frontiers in Food Science and Technology

Frontiers in Forests and Global Change

Frontiers in Freshwater Science

Frontiers in Fuels

Frontiers in Fungal Biology

Frontiers in Future Transportation

Frontiers in Gastroenterology

Frontiers in Genetics

Year: 2023 Month: August Volume: 14

Year: 2023 Month: July Volume: 14

Year: 2023 Month: June Volume: 14

Year: 2023 Month: May Volume: 14

Year: 2023 Month: April Volume: 14

Year: 2023 Month: April Volume: 13

Year: 2023 Month: March Volume: 14

Year: 2023 Month: March Volume: 13

Year: 2023 Month: February Volume: 14

Year: 2023 Month: February Volume: 13

Year: 2023 Month: January Volume: 14

Year: 2023 Month: January Volume: 13

Year: 2022 Month: December Volume: 13

Year: 2022 Month: November Volume: 13

Year: 2022 Month: October Volume: 13

Year: 2022 Month: September Volume: 13

Year: 2022 Month: August Volume: 13

Year: 2022 Month: July Volume: 13

Year: 2022 Month: July Volume: 12

Year: 2022 Month: June Volume: 13

Year: 2022 Month: June Volume: 12

Year: 2022 Month: May Volume: 13

Advances in CRISPR-Based Functional Genomics and Nucleic Acid Detection in Pigs

Epigenetic Alterations of DNA Methylation and miRNA Contribution to Lung Adenocarcinoma

Comparative Analysis of the Chloroplast Genome for Aconitum Species: Genome Structure and Phylogenetic Relationships

StarGazer: A Hybrid Intelligence Platform for Drug Target Prioritization and Digital Drug Repositioning Using Streamlit

Expression and Secretion of Circular RNAs in the Parasitic Nematode, Ascaris suum

Genome-Wide Association Study and Genomic Prediction for Bacterial Wilt Resistance in Common Bean (Phaseolus vulgaris) Core Collection

A Ubiquitin-Proteasome Gene Signature for Predicting Prognosis in Patients With Lung Adenocarcinoma

The Evaluation of Genetic Diagnosis on High-Risk Fetal CAKUT

Editorial: Machine Learning for Big Data Analysis: Applications in Plant Breeding and Genomics

DNA Methylation Analysis of Turner Syndrome BAV

Case Report: Rare Homozygous RNASEH1 Mutations Associated With Adult-Onset Mitochondrial Encephalomyopathy and Multiple Mitochondrial DNA Deletions

Developmental Validation of the Novel Five-Dye-Labeled Multiplex Autosomal STR Panel and Its Forensic Efficiency Evaluation

Comprehensive Analysis of circRNAs, miRNAs, and mRNAs Expression Profiles and ceRNA Networks in Decidua of Unexplained Recurrent Spontaneous Abortion

Identification of a lncRNA AC011511.5- Mediated Competitive Endogenous RNA Network Involved in the Pathogenesis of Allergic Rhinitis

Differential Expression of Genes Regulating Store-operated Calcium Entry in Conjunction With Mitochondrial Dynamics as Potential Biomarkers for Cancer: A Single-Cell RNA Analysis

ProtTrans-Glutar: Incorporating Features From Pre-trained Transformer-Based Models for Predicting Glutarylation Sites

ANXA1: An Important Independent Prognostic Factor and Molecular Target in Glioma

Case Report: Phenotype-Driven Diagnosis of Atypical Dravet-Like Syndrome Caused by a Novel Splicing Variant in the SCN2A Gene

Revealing Potential Spinal Cord Injury Biomarkers and Immune Cell Infiltration Characteristics in Mice

The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus

Detection and Validation of Circular DNA Fragments Using Nanopore Sequencing

CILP, a Putative Gene Associated With Immune Infiltration in Breast Cancer Brain Metastases

Genome-Wide Selection Signatures and Human-Mediated Introgression Events in Bos taurus indicus-influenced Composite Beef Cattle

Case Report: MYO5B Homozygous Variant c.2090+3A>T Causes Intron Retention Related to Chronic Cholestasis and Diarrhea

Identification of Extracellular Matrix Signatures as Novel Potential Prognostic Biomarkers in Lung Adenocarcinoma

Identification of FCER1G related to Activated Memory CD4+ T Cells Infiltration by Gene Co-expression Network and Construction of a Risk Prediction Module in Diffuse Large B-Cell Lymphoma

Identification of Core Genes and Screening of Potential Targets in Intervertebral Disc Degeneration Using Integrated Bioinformatics Analysis

How the Replication and Transcription Complex Functions in Jumping Transcription of SARS-CoV-2

The Inflamm-Aging Model Identifies Key Risk Factors in Atherosclerosis

Identifying Antidepressant Effects of Brain-Derived Neurotrophic Factor and IDO1 in the Mouse Model Based on RNA-Seq Data

Developing a National Newborn Genomes Program: An Approach Driven by Ethics, Engagement and Co-design

Psychosocial Effects of Receiving Genome-Wide Polygenic Risk Information Concerning Type 2 Diabetes and Coronary Heart Disease: A Randomized Controlled Trial

An Insight Into Pentatricopeptide-Mediated Chloroplast Necrosis via microRNA395a During Rhizoctonia solani Infection

A Nomogram for Predicting the Risk of Bone Metastasis in Newly Diagnosed Head and Neck Cancer Patients: A Real-World Data Retrospective Cohort Study From SEER Database

The Prognostic Signature and Therapeutic Value of Phagocytic Regulatory Factors in Prostate Adenocarcinoma (PRAD)

An Interaction-Based Method for Refining Results From Gene Set Enrichment Analysis

Whole-Genome Analysis Deciphers Population Structure and Genetic Introgression Among Bovine Species

Chromosome-Level Haplotype Assembly for Equus asinu

Case Report: Identification Pathogenic Abnormal Splicing of BBS1 Causing Bardet–Biedl Syndrome Type I (BBS1) due to Missense Mutation

Establishment and Phenotypic Analysis of the Novel Gaucher Disease Mouse Model With the Partially Humanized Gba1 Gene and F213I Mutation

Ancient Mitogenomes Reveal the Origins and Genetic Structure of the Neolithic Shimao Population in Northern China

CNTN-1 Upregulation Induced by Low-Dose Cisplatin Promotes Malignant Progression of Lung Adenocarcinoma Cells via Activation of Epithelial-Mesenchymal Transition

Whole-Genome Resequencing of Xiangxi Cattle Identifies Genomic Diversity and Selection Signatures

Identification of a Novel Canonical Splice Site Variant TSC2 c.2967-1G>T That is Not Associated With Tuberous Sclerosis Pathogenesis

Identification of Immune Infiltration-Related ceRNAs as Novel Biomarkers for Prognosis of Patients With Primary Open-Angle Glaucoma

Identification of CD8+ T Cell Related Biomarkers in Ovarian Cancer

GmARP is Related to the Type III Effector NopAA to Promote Nodulation in Soybean (Glycine max)

Necroptosis-Related miRNA Biomarkers for Predicting Overall Survival Outcomes for Endometrial Cancer

Identification of DNAH17 Variants in Han-Chinese Patients With Left–Right Asymmetry Disorders

Development of a Novel Immune-Related Gene Signature to Predict Prognosis and Immunotherapeutic Efficiency in Gastric Cancer

Genetic Analysis of the LOXHD1 Gene in Chinese Patients With Non-Syndromic Hearing Loss

Case Report: A de novo Variant of CRYGC Gene Associated With Congenital Cataract and Microphthalmia

Forensic Efficiency Estimation of a Homemade Six-Color Fluorescence Multiplex Panel and In-Depth Anatomy of the Population Genetic Architecture in Two Tibetan Groups

SLC6A8 is a Potential Biomarker for Poor Prognosis in Lung Adenocarcinoma

Identification of an Endoplasmic Reticulum Stress-Related Gene Signature to Evaluate the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma

The Mitochondrial tRNAPhe 625G>A Mutation in Three Han Chinese Families With Cholecystolithiasis

The Chemokines Initiating and Maintaining Immune Hot Phenotype Are Prognostic in ICB of HNSCC

Asian Swamp eel Monopterus albus Population Structure and Genetic Diversity in China

Using Long-Term Follow-Up Data to Classify Genetic Variants in Newborn Screened Conditions

Application of Induced Pluripotent Stem Cell-Derived Models for Investigating microRNA Regulation in Developmental Processes

An m6A/m5C/m1A/m7G-Related Long Non-coding RNA Signature to Predict Prognosis and Immune Features of Glioma

Case Report: Balanced Reciprocal Translocation t (17; 22) (p11.2; q11.2) and 10q23.31 Microduplication in an Infertile Male Patient Suffering From Teratozoospermia

Selecting for Feed Efficient Cows Will Help to Reduce Methane Gas Emissions

Prediction of Prognosis and Immunotherapy of Osteosarcoma Based on Necroptosis-Related lncRNAs

Editorial: Advancement in Gene Set Analysis: Gaining Insight From High-Throughput Data

Integration of Protein-Protein Interaction Networks and Gene Expression Profiles Helps Detect Pancreatic Adenocarcinoma Candidate Genes

SpatialMap: Spatial Mapping of Unmeasured Gene Expression Profiles in Spatial Transcriptomic Data Using Generalized Linear Spatial Models

Identification of Immune-Related Genes for Risk Stratification in Multiple Myeloma Based on Whole Bone Marrow Gene Expression Profiling

Bridging the Gap Between Environmental Adversity and Neuropsychiatric Disorders: The Role of Transposable Elements

Predicting Differences in Treatment Response and Survival Time of Lung Adenocarcinoma Patients Based on a Prognostic Risk Model of Glycolysis-Related Genes

Construction and Validation of a 6-Ferroptosis Related Gene Signature for Prognosis and Immune Landscape Prediction in Melanoma

Repetitive Elements, Sequence Turnover and Cyto-Nuclear Gene Transfer in Gymnosperm Mitogenomes

Expression of Concern: Novel Genetic Signatures Associated With Sporadic Amyotrophic Lateral Sclerosis

Editorial: Machine Learning-Based Methods for RNA Data Analysis

Identification of Biomarkers for Predicting Ovarian Reserve of Primordial Follicle via Transcriptomic Analysis

Presence of Circulatory Autoantibodies Against ROS-Modified Histone H1 Protein in Lymphoma Patients

Association of PTPN22 SNP1858 (rs2476601) and Gene SNP1123 (rs2488457) Polymorphism With Primary Immune Thrombocytopenia Susceptibility: A Meta-Analysis of Case-Control Studies and Trial Sequential Analysis

Screening the Potential Biomarkers of COVID-19-Related Thrombosis Through Bioinformatics Analysis

Neuron-Specific Deletion of Scrib in Mice Leads to Neuroanatomical and Locomotor Deficits

Fine Mapping of a Major Backfat QTL Reveals a Causal Regulatory Variant Affecting the CCND2 Gene

A RE-AIM Framework Analysis of DNA-Based Population Screening: Using Implementation Science to Translate Research Into Practice in a Healthcare System

Necroptosis is Related to Anti-PD-1 Treatment Response and Influences the Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma

Editorial: Biomarker Detection Algorithms and Tools for Medical Imaging or Omics Data

KIF2C is a Biomarker Correlated With Prognosis and Immunosuppressive Microenvironment in Human Tumors

Pharmacogenetic Review: Germline Genetic Variants Possessing Increased Cancer Risk With Clinically Actionable Therapeutic Relationships

Pursuing Public Health Benefit Within National Genomic Initiatives: Learning From Different Policies

A Prognostic Signature for Clear Cell Renal Cell Carcinoma Based on Ferroptosis-Related lncRNAs and Immune Checkpoints

Interpretable Deep Learning Model Reveals Subsequences of Various Functions for Long Non-Coding RNA Identification

Identification and Expression Analysis of Calcium-Dependent Protein Kinases Gene Family in Potato Under Drought Stress

Population Structure, Genetic Diversity, and Conservation Strategies of a Commercially Important Sleeper Fish, Odontobutis potamophilus (Gobiiformes: Odontobutidae) Based on Gene-Capture Data

Comparative Transcriptome Analysis Reveals the Process of Ovarian Development and Nutrition Metabolism in Chinese Mitten Crab, Eriocheir Sinensis

Identification of Novel Genetic Variants and Comorbidities Associated With ICD-10-Based Diagnosis of Hypertrophic Cardiomyopathy Using the UK Biobank Cohort

An Integrative Pan-Cancer Analysis Revealing MLN4924 (Pevonedistat) as a Potential Therapeutic Agent Targeting Skp2 in YAP-Driven Cancers

Case Report: Clinical and Genetic Characteristics of Pearson Syndrome in a Chinese Boy and 139 Patients

Members of the Chromobox Family Have Prognostic Value in Hepatocellular Carcinoma

Telomere Length and COVID-19 Outcomes: A Two-Sample Bidirectional Mendelian Randomization Study

Characterization of the Immune Cell Infiltration Landscape Uncovers Prognostic and Immunogenic Characteristics in Lung Adenocarcinoma

Revealing the Critical Regulators of Modulated Smooth Muscle Cells in Atherosclerosis in Mice

An Immune-Related Prognostic Signature Predicts Overall Survival in Stomach Adenocarcinomas

RNA-Seq Analysis of the Growth Hormone Transgenic Female Triploid Atlantic Salmon (Salmo salar) Hepatic Transcriptome Reveals Broad Temperature-Mediated Effects on Metabolism and Other Biological Processes

A Connexin Gene (GJB3) Mutation in a Chinese Family With Erythrokeratodermia Variabilis, Ichthyosis and Nonsyndromic Hearing Loss: Case Report and Mutations Update

Multistage Combination Classifier Augmented Model for Protein Secondary Structure Prediction

De Novo Assembly of Plasmodium knowlesi Genomes From Clinical Samples Explains the Counterintuitive Intrachromosomal Organization of Variant SICAvar and kir Multiple Gene Family Members

“Let’s Just Wait Until She’s Born”: Temporal Factors That Shape Decision-Making for Prenatal Genomic Sequencing Amongst Families Underrepresented in Genomic Research

Biological and Clinicopathological Characteristics of OPN in Cervical Cancers

The Genetic Spectrum of Familial Hypertriglyceridemia in Oman

Editorial: Genome Wide Association Studies and Genomic Selection for Crop Improvement in the Era of Big Data

Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated Loci

Case Report: Brachydactyly Type A1 Induced by a Novel Variant of in-Frame Insertion in the IHH Gene

The Four Key Genes Participated in and Maintained Atrial Fibrillation Process via Reprogramming Lipid Metabolism in AF Patients

Association Between C-Reactive Protein and Risk of Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study

New Era of Mapping and Understanding Common Fragile Sites: An Updated Review on Origin of Chromosome Fragility

Single-Cell Transcriptomics-Based Study of Transcriptional Regulatory Features in the Non-Obstructive Azoospermia Testis

Transcriptome Analysis Reveals Molecular Underpinnings of Common Carp (Cyprinus carpio) Under Hypoxia Stress

MicroRNA Expression in Circulating Leukocytes and Bioinformatic Analysis of Patients With Moyamoya Disease

Digital Cell Atlas of Mouse Uterus: From Regenerative Stage to Maturational Stage

Chickpea Biofortification for Cytokinin Dehydrogenase via Genome Editing to Enhance Abiotic-Biotic Stress Tolerance and Food Security

Weighted Gene Co-Expression Network Analysis (WGCNA) Reveals the Functions of Syndecan-1 to Regulate Immune Infiltration by Influenced T Cells in Glioma

Discovery and Validation of a Novel Metastasis-Related lncRNA Prognostic Signature for Colorectal Cancer

MCM10 is a Prognostic Biomarker and Correlated With Immune Checkpoints in Ovarian Cancer

Contrasting Patterns of Genetic Diversity and Divergence Between Landlocked and Migratory Populations of Fish Galaxias maculatus, Evaluated Through Mitochondrial DNA Sequencing and Nuclear DNA Microsatellites

Editorial: B Cell Non-Hodgkin’s Lymphoma & Tumor Microenvironment Crosstalk: An Epigenetic Matter?

Expression Level Dominance and Homeolog Expression Bias Upon Cold Stress in the F1 Hybrid Between the Invasive Sphagneticola trilobata and the Native S. calendulacea in South China, and Implications for Its Invasiveness

INSC Is Down-Regulated in Colon Cancer and Correlated to Immune Infiltration

Identification of Candidate Therapeutic Genes for More Precise Treatment of Esophageal Squamous Cell Carcinoma and Adenocarcinoma

Population Genetics and Phylogeography of Galapagos Fur Seals

Phylogenetic Analysis of Small Hive Beetles From Native to Introduced Populations

Omeprazole Treatment Failure in Gastroesophageal Reflux Disease and Genetic Variation at the CYP2C Locus

Benchmarking Low-Frequency Variant Calling With Long-Read Data on Mitochondrial DNA

Pharmacokinetics and Genetic Factors of Atorvastatin in Healthy Korean Subjects

An Adaptive and Robust Test for Microbial Community Analysis

Pyroptosis-Related Gene Signature Predicts the Prognosis and Immune Infiltration in Neuroblastoma

Evolutionary Genomics Reveals Multiple Functions of Arylalkylamine N-Acetyltransferase in Fish

Gene Regulatory Identification Based on the Novel Hybrid Time-Delayed Method

NAP1L1 Functions as a Novel Prognostic Biomarker Associated With Macrophages and Promotes Tumor Progression by Influencing the Wnt/β-Catenin Pathway in Hepatocellular Carcinoma

Prognostic Significance of Lineage Diversity in Bladder Cancer Revealed by Single-Cell Sequencing

First Report on CRISPR/Cas9-Based Genome Editing in the Destructive Invasive Pest Tuta Absoluta (Meyrick) (Lepidoptera: Gelechiidae)

Innovative in Silico Approaches for Characterization of Genes and Proteins

Improvement of Genomic Predictions in Small Breeds by Construction of Genomic Relationship Matrix Through Variable Selection

Plant Genotype to Phenotype Prediction Using Machine Learning

Chromosome-Scale, Haplotype-Resolved Genome Assembly of Non-Sex-Reversal Females of Swamp Eel Using High-Fidelity Long Reads and Hi-C Data

Comparative Genomic-Based Study of Reproduction-Related Genes in Three Fruit Fly Species

A Prognostic Survival Model of Pancreatic Adenocarcinoma Based on Metabolism-Related Gene Expression

Identification of mRNA Signature for Predicting Prognosis Risk of Rectal Adenocarcinoma

Unravelling the Role of Epigenetic Modifications in Development and Reproduction of Angiosperms: A Critical Appraisal

Molecular Genetics and Pathogenesis of the Floating Harbor Syndrome: Case Report of Long-Term Growth Hormone Treatment and a Literature Review

SPDL1 Overexpression Is Associated With the 18F-FDG PET/CT Metabolic Parameters, Prognosis, and Progression of Esophageal Cancer

A Random Forest-Based Genome-Wide Scan Reveals Fertility-Related Candidate Genes and Potential Inter-Chromosomal Epistatic Regions Associated With Age at First Calving in Nellore Cattle

Comprehensive Analysis of the Immune Cell Infiltration Landscape and Immune-Related Methylation in Retinoblastoma

Comparative Analysis of the Gut Microbiota of Mandarin Fish (Siniperca chuatsi) Feeding on Compound Diets and Live Baits

Comprehensive Analysis of Programmed Cell Death Signature in the Prognosis, Tumor Microenvironment and Drug Sensitivity in Lung Adenocarcinoma

Context-Aware Phylogenetic Trees for Phylogeny-Based Taxonomy Visualization

TGFβ-Associated Signature Predicts Prognosis and Tumor Microenvironment Infiltration Characterization in Gastric Carcinoma

Identifying Quantitative Trait Loci for Thousand Grain Weight in Eggplant by Genome Re-Sequencing Analysis

Systems-Level Mapping of Cancer Testis Antigen 1b/a to Sarcoma Pathways Identifies Activated Ran Binding-2 E3 SUMO-Protein Ligase and Transducin-Like Enhancer Protein 1

NFE2L3 as a Novel Biomarker Associated With IL-2/STAT5/NLRP3 Signaling Pathway in Malignant Pleural Mesothelioma and Other Cancers

Case Report: Adolescent-Onset Isolated Nephronophthisis Caused by a Novel Homozygous Inversin Mutation

Dissecting Meta-Analysis in GWAS Era: Bayesian Framework for Gene/Subnetwork-Specific Meta-Analysis

Neuronal Cells Display Distinct Stability Controls of Alternative Polyadenylation mRNA Isoforms, Long Non-Coding RNAs, and Mitochondrial RNAs

Cross-Species Analysis Reveals Co-Expressed Genes Regulating Antler Development in Cervidae

Angiogenic Factor-Based Signature Predicts Prognosis and Immunotherapy Response in Non-Small-Cell Lung Cancer

A Potential Indicator ARRDC2 Has Feasibility to Evaluate Prognosis and Immune Microenvironment in Ovarian Cancer

RC-Net: Regression Correction for End-To-End Chromosome Instance Segmentation

Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma

Corrigendum: Identification of Signature Genes Associated With Invasiveness and the Construction of a Prognostic Model That Predicts the Overall Survival of Bladder Cancer

Analysis of Whole-Transcriptome RNA-Seq Data Reveals the Involvement of Alternative Splicing in the Drought Response of Glycyrrhiza uralensis

A DNA Damage Repair Gene Signature Associated With Immunotherapy Response and Clinical Prognosis in Clear Cell Renal Cell Carcinoma

BBPpredict: A Web Service for Identifying Blood-Brain Barrier Penetrating Peptides

Effect of SLC16A1 on Hepatic Glucose Metabolism in Newborn and Post-Weaned Holstein Bulls

Evidence of Paternal Effects on Telomere Length Increases in Early Life

Comprehensive Biochemical, Physiological, and Transcriptomic Analyses Provide Insights Into Floral Bud Dormancy in Rhododendron delavayi Franch

Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study

Discovering miRNAs Associated With Multiple Sclerosis Based on Network Representation Learning and Deep Learning Methods

Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia

New Insights on the Regulatory Gene Network Disturbed in Central Areolar Choroidal Dystrophy—Beyond Classical Gene Candidates

Prognostic and Immunological Role of PPP1R14A as a Pan-Cancer Analysis Candidate

Stool and Ruminal Microbiome Components Associated With Methane Emission and Feed Efficiency in Nelore Beef Cattle

Polymorphism of Sex Determination Amongst Wild Populations Suggests its Rapid Turnover Within the Nile Tilapia Species

Sleep and Late-Onset Alzheimer’s Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects

Rare Alleles and Signatures of Selection on the Immunodominant Domains of Pfs230 and Pfs48/45 in Malaria Parasites From Western Kenya

Conservation and Diversity of miR166 Family Members From Highbush Blueberry (Vaccinium corymbosum) and Their Potential Functions in Abiotic Stress

First Chromosome-Scale Assembly and Deep Floral-Bud Transcriptome of a Male Kiwifruit

Prenatal Diagnosis of Chromosomal Mosaicism in Over 18,000 Pregnancies: A Five-Year Single-Tertiary-Center Retrospective Analysis

Integrated Analysis Reveals Critical Ferroptosis Regulators and FTL Contribute to Cancer Progression in Hepatocellular Carcinoma

Genome Re-Sequencing Reveals the Host-Specific Origin of Genetic Variation in Magnaporthe Species

Identifying Functions of Proteins in Mice With Functional Embedding Features

Uncovering BTB and CNC Homology1 (BACH1) as a Novel Cancer Therapeutic Target

Identifying Candidate Genes for Short Gestation Length Trait in Chinese Qingping Pigs by Whole-Genome Resequencing and RNA Sequencing

Evaluation of Biomarkers and Immune Microenvironment of Osteoarthritis: Evidence From Omics Data and Machine Learning

Case Report: Novel Biallelic Null Variants of SMPD4 Confirm Its Involvement in Neurodevelopmental Disorder With Microcephaly, Arthrogryposis, and Structural Brain Anomalies

An Integrated Regulatory Network of mRNAs, microRNAs, and lncRNAs Involved in Nitrogen Metabolism of Moso Bamboo

2b-RAD Genotyping of the Seagrass Cymodocea nodosa Along a Latitudinal Cline Identifies Candidate Genes for Environmental Adaptation

Genome-Wide Identification and Characterization of Long Non-Coding RNAs in Longissimus dorsi Skeletal Muscle of Shandong Black Cattle and Luxi Cattle

Spectrum of Mutations in NDP Resulting in Ocular Disease; a Systematic Review

Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers

Meckel’s Cartilage in Mandibular Development and Dysmorphogenesis

Nomogram Model Based on Clinical Risk Factors and Heart Rate Variability for Predicting All-Cause Mortality in Stage 5 CKD Patients

Breaking the Immune Complexity of the Tumor Microenvironment Using Single-Cell Technologies

Identification of Novel Characteristics in TP53-Mutant Hepatocellular Carcinoma Using Bioinformatics

Association Study Between Polymorphic Loci in Cholesterol Metabolism Pathway and Gallstone in the Tibetan Population

Case Report: Hemophagocytic Lymphohistiocytosis Prior to the Onset of Leukemia in a Boy With CDK13-Related Disorder

Primary Cell Lines From Feathers and Blood of Free-Living Tawny Owls (Strix aluco): A New In Vitro Tool for Non-Lethal Toxicological Studies

Inter-Residue Distance Prediction From Duet Deep Learning Models

Corrigendum: Network Crosstalk as a Basis for Drug Repurposing

Novel Missense and Splice Site Mutations in USH2A, CDH23, PCDH15, and ADGRV1 Are Associated With Usher Syndrome in Lebanon

Editorial: Methods for Single-Cell and Microbiome Sequencing Data

Heterogeneous Skeletal Muscle Cell and Nucleus Populations Identified by Single-Cell and Single-Nucleus Resolution Transcriptome Assays

Selection and Evaluation of Reference Genes for miRNA Expression Analysis in Bemisia tabaci Under Insecticide Tolerance

Transcriptomic Analysis Reveals Endometrial Dynamics in Normoweight and Overweight/Obese Polycystic Ovary Syndrome Women

A Novel Homozygous Missense Mutation of PIEZO1 Leading to Lymphatic Malformation-6 Identified in a Family With Three Adverse Pregnancy Outcomes due to Nonimmune Fetal Hydrops

Comparative Proteome Profiling of Saliva Between Estrus and Non-Estrus Stages by Employing Label-Free Quantitation (LFQ) and Tandem Mass Tag (TMT)-LC-MS/MS Analysis: An Approach for Estrus Biomarker Identification in Bubalus bubalis

A New Risk Model Based on 7 Quercetin-Related Target Genes for Predicting the Prognosis of Patients With Lung Adenocarcinoma

HMG-CoA Lyase Deficiency: A Retrospective Study of 62 Saudi Patients

Molecular Subtyping of Cancer Based on Robust Graph Neural Network and Multi-Omics Data Integration

Structural Features of the Nucleosomal DNA Modulate the Functional Binding of a Transcription Factor and Productive Transcription

Population Structure of Curraleiro Pé-Duro Cattle and its Relationship With the Serological Profile Against Pathogens of Economic and Zoonotic Interest

Identification of Novel Imatinib-Resistant Genes in Gastrointestinal Stromal Tumors

Editorial: MicroRNAs and Muscle Cell Death in Cancer

Placental DNA Methylation Abnormalities in Prenatal Conotruncal Heart Defects

Identifying and Exploring the Candidate Susceptibility Genes of Cirrhosis Using the Multi-Tissue Transcriptome-Wide Association Study

TROY Modulates Cancer Stem-Like Cell Properties and Gefitinib Resistance Through EMT Signaling in Non–Small Cell Lung Cancer

A Novel Five-Gene Signature Related to Clinical Outcome and Immune Microenvironment in Breast Cancer

Down Syndrome Fetal Fibroblasts Display Alterations of Endosomal Trafficking Possibly due to SYNJ1 Overexpression

Placental Gene Transcript Proportions are Altered in the Presence of In Utero Arsenic and Cadmium Exposures, Genetic Variants, and Birth Weight Differences

Amino Acid Metabolism-Related lncRNA Signature Predicts the Prognosis of Breast Cancer

Genomics in Egypt: Current Status and Future Aspects

rs401502 and rs11575934 Polymorphisms of the IL-12 Receptor Beta 1 Gene are Protective Against Colorectal Carcinogenesis

Genome-Wide Analysis of NBS-LRR Genes From an Early-Diverging Angiosperm Euryale ferox

Comparative Transcriptome Analyses Characterize Expression Signatures Among Males, Females, Neo-Males, and Gynogenetic Females in the Yellow Drum (Nibea albiflora)

Enhancing Long-Read-Based Strain-Aware Metagenome Assembly

Utilizing Public Health Frameworks and Partnerships to Ensure Equity in DNA-Based Population Screening

Identification of Immunological Characteristics and Immune Subtypes Based on Single-Sample Gene Set Enrichment Analysis Algorithm in Lower-Grade Glioma

An Aging and Senescence-Related Gene Signature for Prognosis Prediction in Clear Cell Renal Cell Carcinoma

Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements

Identification of Context-Specific Fitness Genes Associated With Metabolic Rearrangements for Prognosis and Potential Treatment Targets for Liver Cancer

SLC4A4, FRAS1, and SULT1A1 Genetic Variations Associated With Dabigatran Metabolism in a Healthy Chinese Population

Tyrosine Phosphorylation Profiling Revealed the Signaling Network Characteristics of CAMKK2 in Gastric Adenocarcinoma

Identification of Two m6A Readers YTHDF1 and IGF2BP2 as Immune Biomarkers in Head and Neck Squamous Cell Carcinoma

Analysis of the Expression and Role of Keratin 17 in Human Tumors

Case Report: Challenges of Non-Invasive Prenatal Testing (NIPT): A Case Report of Confined Placental Mosaicism and Clinical Considerations

Comprehensive Analysis of the Expression and Prognosis for the DREAM Complex in Human Cancers

Education and Consent for Population-Based DNA Screening: A Mixed-Methods Evaluation of the Early Check Newborn Screening Pilot Study

The Landscape of the Tumor-Infiltrating Immune Cell and Prognostic Nomogram in Colorectal Cancer

The Mutation Analysis of the AMT Gene in a Chinese Family With Nonketotic Hyperglycinemia

Whole Genome Sequencing Provides New Insights Into the Genetic Diversity and Coat Color of Asiatic Wild Ass and Its Hybrids

Multi-Size Deep Learning Based Preoperative Computed Tomography Signature for Prognosis Prediction of Colorectal Cancer

High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes

Study of the Combined Effect of Maternal Tobacco Smoking and Polygenic Risk Scores on Birth Weight and Body Mass Index in Childhood

SLC44A2 Frequency, a New TaqMan Real-Time Polymerase Chain Reaction Method for HNA-3A/3B Genotyping, and a New Application of Droplet Digital PCR

RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration

Three Novel De Novo ZEB2 Variants Identified in Three Unrelated Chinese Patients With Mowat-Wilson Syndrome and A Systematic Review

An Integrated Systematic Analysis and the Clinical Significance of Hepcidin in Common Malignancies of the Male Genitourinary System

Identification and Verification of Feature Biomarkers Associated With Immune Cells in Dilated Cardiomyopathy by Bioinformatics Analysis

Whole-Genome/Exome Sequencing Uncovers Mutations and Copy Number Variations in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Characteristics of Genomic Alterations in Pericardial Effusion of Advanced Non-small Cell Lung Cancer

Heterologous Expression of Arabidopsis AtARA6 in Soybean Enhances Salt Tolerance

Chromosome-Scale, Haplotype-Resolved Genome Assembly of Suaeda Glauca

Whole-Transcriptome Analysis Reveals Long Noncoding RNAs Involved in Female Floral Development of Hickory (Carya cathayensis Sarg.)

Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma

Upregulation of Ferroptosis-Related Fanconi Anemia Group D2 is a Poor Prognostic Factor and an Indicator of Tumor Immune Cell Infiltration in Lung Adenocarcinoma

De Novo Large Deletion Leading to Fragile X Syndrome

Prognostic Value of SPOCD1 in Esophageal Squamous Cell Carcinoma: A Comprehensive Study Based on Bioinformatics and Validation

QTL Mapping of Adult Plant Resistance to Stripe Rust in a Doubled Haploid Wheat Population

Hybrid Assembly and Annotation of the Genome of the Indian Punica granatum, a Superfood

Shared and Cell-Type-Specific Gene Expression Patterns Associated With Autism Revealed by Integrative Regularized Non-Negative Matrix Factorization

Eating Time as a Genetic Indicator of Methane Emissions and Feed Efficiency in Australian Maternal Composite Sheep

Identification of a Cancer Stem Cells Signature of Head and Neck Squamous Cell Carcinoma

Immune Landscape and Classification in Lung Adenocarcinoma Based on a Novel Cell Cycle Checkpoints Related Signature for Predicting Prognosis and Therapeutic Response

Multi-Omic Data Improve Prediction of Personalized Tumor Suppressors and Oncogenes

Effect of Panicle Morphology on Grain Filling and Rice Yield: Genetic Control and Molecular Regulation

Sirtuins—Novel Regulators of Epigenetic Alterations in Airway Inflammation

Establishment of a Novel Combined Nomogram for Predicting the Risk of Progression Related to Castration Resistance in Patients With Prostate Cancer

The Spectrum of ACAN Gene Mutations in a Selected Chinese Cohort of Short Stature: Genotype-Phenotype Correlation

Editorial: Bioinformatics and the Translation of Data-Driven Discoveries

Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45

TGFβ2 is a Prognostic Biomarker for Gastric Cancer and is Associated With Methylation and Immunotherapy Responses

African Genetic Representation in the Context of SARS-CoV-2 Infection and COVID-19 Severity

Association of a Novel DOCK2 Mutation-Related Gene Signature With Immune in Hepatocellular Carcinoma

Genome-Wide Association Mapping Reveals Novel Putative Gene Candidates Governing Reproductive Stage Heat Stress Tolerance in Rice

Benefits and Challenges of Pre-clustered Network-Based Pathway Analysis

Target-Sequencing of Female Infertility Pathogenic Gene Panel and a Novel TUBB8 Loss-of-Function Mutation

A Distinct Glucose Metabolism Signature of Lung Adenocarcinoma With Prognostic Value

Editorial: Non-Coding RNA Mediated Post-Transcriptional Regulation in Human Diseases

Exploration of Potential Biomarker Genes and Pathways in Kawasaki Disease: An Integrated in-Silico Approach

Dynamic Meta-data Network Sparse PCA for Cancer Subtype Biomarker Screening

Editorial: Machine Learning Used in Biomedical Computing and Intelligence Healthcare, Volume II

N6-Methyladenosine-Related lncRNAs Are Novel Prognostic Markers and Predict the Immune Landscape in Acute Myeloid Leukemia

Immune Microenvironment Terms Signature Robustly Predicts the Prognosis and Immunotherapy Response in Bladder Cancer Based on Large Population Cohorts

Long-Read Sequencing Revealed Extragenic and Intragenic Duplications of Exons 56–61 in DMD in an Asymptomatic Male and a DMD Patient

Editorial: Teratogenesis: Experimental Models, Mechanisms and Clinical Findings in Humans

Transmembrane Protein 170B is a Prognostic Biomarker and Associated With Immune Infiltrates in Pancreatic Adenocarcinoma

A Comparison of Methods for Gene-Based Testing That Account for Linkage Disequilibrium

Production of Conjoined Transgenic and Edited Barley and Wheat Plants for Nud Genes Using the CRISPR/SpCas9 System

Profiling the Genome-Wide Landscape of Short Tandem Repeats by Long-Read Sequencing

Comprehensive Analysis of lncRNAs, miRNAs and mRNAs in Mouse Hippocampus With Hepatic Encephalopathy

Case Report: Hereditary Fibrosing Poikiloderma With Tendon Contractures, Myopathy, and Pulmonary Fibrosis (POIKTMP) Presenting With Liver Cirrhosis and Steroid-Responsive Interstitial Pneumonia

The Association Between Vitamin C and Cancer: A Two-Sample Mendelian Randomization Study

kngMap: Sensitive and Fast Mapping Algorithm for Noisy Long Reads Based on the K-Mer Neighborhood Graph

Single-Cell Transcriptomics Uncovers Cellular Heterogeneity, Mechanisms, and Therapeutic Targets for Parkinson’s Disease

DEAD-Box Helicase 27 Triggers Epithelial to Mesenchymal Transition by Regulating Alternative Splicing of Lipoma-Preferred Partner in Gastric Cancer Metastasis

The Genetic Differentiation of Pyrrhulina (Teleostei, Characiformes) Species is Likely Influenced by Both Geographical Distribution and Chromosomal Rearrangements

Comprehensive Analysis of N6-Methyladenosine-Related Long Noncoding RNA Prognosis of Acute Myeloid Leukemia and Immune Cell Infiltration

Unraveling T Cell Responses for Long Term Protection of SARS-CoV-2 Infection

The Effect of miRNA Gene Regulation on HIV Disease

Computational Analysis Reveals the Characteristics of Immune Cells in Glomerular and Tubulointerstitial Compartments in IgA Nephropathy Patients

Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle

Single-Cell RNA-Seq and Bulk RNA-Seq Reveal Intratumoral Heterogeneity and Tumor Microenvironment Characteristics in Diffuse Large B-Cell Lymphoma

What’s Shape Got to Do With It? Examining the Relationship Between Facial Shape and Orofacial Clefting

NISC: Neural Network-Imputation for Single-Cell RNA Sequencing and Cell Type Clustering

Suberoylanilide Hydroxamic Acid (SAHA) Treatment Reveals Crosstalk Among Proteome, Phosphoproteome, and Acetylome in Nasopharyngeal Carcinoma Cells

A Panel of E2F Target Gene Signature Predicting the Prognosis of Hepatocellular Carcinoma

Genetic and Biological Effects of SLC12A3, a Sodium-Chloride Cotransporter, in Gitelman Syndrome and Diabetic Kidney Disease

Single Nucleotide Polymorphism Effects on Lamb Fecal Egg Count Estimated Breeding Values in Progeny-Tested Katahdin Sires

An Integrated Immune-Related Bioinformatics Analysis in Glioma: Prognostic Signature’s Identification and Multi-Omics Mechanisms’ Exploration

The Role of MicroRNA in DNA Damage Response

i5hmCVec: Identifying 5-Hydroxymethylcytosine Sites of Drosophila RNA Using Sequence Feature Embeddings

Prognostic Biomarker KIF18A and Its Correlations With Immune Infiltrates and Mitosis in Glioma

TGF-β Signaling Pathway-Based Model to Predict the Subtype and Prognosis of Head and Neck Squamous Cell Carcinoma

Editorial: Omics of Human Aging and Longevity in the Post Genome Era: From Single Biomarkers to Systems Biology Approaches

Molecular Subtyping of Cancer Based on Distinguishing Co-Expression Modules and Machine Learning

Causal Effects of Genetically Predicted Cystatin C on Osteoporosis: A Two-Sample Mendelian Randomization Study

Magnesium- a Forgotten Element: Phenotypic Variation and Genome Wide Association Study in Turkish Common Bean Germplasm

ILF2 Contributes to Hyperproliferation of Keratinocytes and Skin Inflammation in a KLHDC7B-DT-Dependent Manner in Psoriasis

Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of PLOD2

Immune Infiltration Characteristics and a Gene Prognostic Signature Associated With the Immune Infiltration in Head and Neck Squamous Cell Carcinoma

Regulation of Plant Tannin Synthesis in Crop Species

Pan-Cancer Study of SHC-Adaptor Protein 1 (SHC1) as a Diagnostic, Prognostic and Immunological Biomarker in Human Cancer

Year: 2022 Month: May Volume: 12

Year: 2022 Month: April Volume: 13

Year: 2022 Month: April Volume: 12

Year: 2022 Month: March Volume: 13

Year: 2022 Month: March Volume: 12

Year: 2022 Month: February Volume: 13

Year: 2022 Month: February Volume: 12

Year: 2022 Month: January Volume: 13

Year: 2022 Month: January Volume: 12

Year: 2021 Month: December Volume: 12

Year: 2021 Month: November Volume: 12

Year: 2021 Month: October Volume: 12

Year: 2021 Month: September Volume: 12

Year: 2021 Month: August Volume: 12

Year: 2021 Month: July Volume: 12

Year: 2021 Month: June Volume: 12

Year: 2021 Month: May Volume: 12

Year: 2021 Month: April Volume: 12

Year: 2021 Month: March Volume: 12

Year: 2021 Month: March Volume: 11

Year: 2021 Month: February Volume: 12

Year: 2021 Month: February Volume: 11

Year: 2021 Month: January Volume: 12

Year: 2021 Month: January Volume: 11

Year: 2020 Month: December Volume: 11

Year: 2020 Month: November Volume: 11

Year: 2020 Month: October Volume: 11

Year: 2020 Month: September Volume: 11

Year: 2020 Month: August Volume: 11

Year: 2020 Month: July Volume: 11

Year: 2020 Month: June Volume: 11

Year: 2020 Month: May Volume: 11

Year: 2020 Month: April Volume: 11

Year: 2020 Month: March Volume: 11

Year: 2020 Month: March Volume: 10

Year: 2020 Month: February Volume: 11

Year: 2020 Month: February Volume: 10

Year: 2020 Month: January Volume: 11

Year: 2020 Month: January Volume: 10

Year: 2019 Month: December Volume: 10

Year: 2019 Month: November Volume: 10

Year: 2019 Month: October Volume: 10

Year: 2019 Month: September Volume: 10

Year: 2019 Month: August Volume: 10

Year: 2019 Month: July Volume: 10

Year: 2019 Month: June Volume: 10

Year: 2019 Month: May Volume: 10

Year: 2019 Month: April Volume: 10

Year: 2019 Month: March Volume: 10

Year: 2019 Month: February Volume: 10

Year: 2019 Month: January Volume: 10

Year: 2019 Month: March Volume: 9

Year: 2019 Month: February Volume: 9

Year: 2019 Month: January Volume: 9

Year: 2018 Month: December Volume: 9

Year: 2018 Month: November Volume: 9

Year: 2018 Month: October Volume: 9

Year: 2018 Month: September Volume: 9

Year: 2018 Month: August Volume: 9

Year: 2018 Month: July Volume: 9

Year: 2018 Month: June Volume: 9

Year: 2018 Month: May Volume: 9

Year: 2018 Month: April Volume: 9

Year: 2018 Month: March Volume: 9

Year: 2018 Month: March Volume: 8

Year: 2018 Month: February Volume: 9

Year: 2018 Month: February Volume: 8

Year: 2018 Month: January Volume: 9

Year: 2018 Month: January Volume: 8

Year: 2017 Month: December Volume: 8

Year: 2017 Month: November Volume: 8

Year: 2017 Month: October Volume: 8

Year: 2017 Month: September Volume: 8

Year: 2017 Month: August Volume: 8

Year: 2017 Month: July Volume: 8

Year: 2017 Month: June Volume: 8

Year: 2017 Month: May Volume: 8

Year: 2017 Month: April Volume: 8

Year: 2017 Month: March Volume: 8

Year: 2017 Month: February Volume: 8

Year: 2017 Month: January Volume: 8

Year: 2017 Month: January Volume: 7

Year: 2016 Month: December Volume: 7

Year: 2016 Month: November Volume: 7

Year: 2016 Month: October Volume: 7

Year: 2016 Month: September Volume: 7

Year: 2016 Month: August Volume: 7

Year: 2016 Month: July Volume: 7

Year: 2016 Month: June Volume: 7

Year: 2016 Month: May Volume: 7

Year: 2016 Month: April Volume: 7

Year: 2016 Month: March Volume: 7

Year: 2016 Month: February Volume: 7

Year: 2016 Month: January Volume: 7

Year: 2016 Month: January Volume: 6

Year: 2015 Month: December Volume: 6

Year: 2015 Month: November Volume: 6

Year: 2015 Month: October Volume: 6

Year: 2015 Month: September Volume: 6

Year: 2015 Month: August Volume: 6

Year: 2015 Month: July Volume: 6

Year: 2015 Month: June Volume: 6

Year: 2015 Month: May Volume: 6

Year: 2015 Month: April Volume: 6

Year: 2015 Month: March Volume: 6

Year: 2015 Month: February Volume: 6

Year: 2015 Month: February Volume: 5

Year: 2015 Month: January Volume: 6

Year: 2015 Month: January Volume: 5

Year: 2014 Month: December Volume: 5

Year: 2014 Month: November Volume: 5

Frontiers in Genome Editing

Frontiers in Geochemistry

Frontiers in Global Women's Health

Frontiers in Health Services

Frontiers in Hematology

Frontiers in High Performance Computing

Frontiers in Horticulture

Frontiers in Human Dynamics

Frontiers in Human Neuroscience

Frontiers in ICT

Frontiers in Imaging

Frontiers in Immunology

Frontiers in Industrial Engineering

Frontiers in Insect Science

Frontiers in Integrative Neuroscience

Frontiers in Lab on a Chip Technologies

Frontiers in Language Sciences

Frontiers in Lupus

Frontiers in Malaria

Frontiers in Mammal Science

Frontiers in Manufacturing Technology

Frontiers in Marine Science

Frontiers in Materials

Frontiers in Mechanical Engineering

Frontiers in Medical Engineering

Frontiers in Medical Technology

Frontiers in Medicine

Frontiers in Membrane Science and Technology

Frontiers in Metals and Alloys

Frontiers in Microbiology

Frontiers in Microbiomes

Frontiers in Molecular Biosciences

Frontiers in Molecular Medicine

Frontiers in Molecular Neuroscience

Frontiers in Nanotechnology

Frontiers in Natural Products

Frontiers in Nephrology

Frontiers in Network Physiology

Frontiers in Neural Circuits

Frontiers in Neuroanatomy

Frontiers in Neuroengineering

Frontiers in Neuroergonomics

Frontiers in Neuroimaging

Frontiers in Neuroinformatics

Frontiers in Neurology

Frontiers in Neurorobotics

Frontiers in Neuroscience

Frontiers in Nuclear Engineering

Frontiers in Nuclear Medicine

Frontiers in Nutrition

Frontiers in Ocean Sustainability

Frontiers in Oncology

Frontiers in Ophthalmology

Frontiers in Oral Health

Frontiers in Pain Research

Frontiers in Parasitology

Frontiers in Pediatrics

Frontiers in Pharmacology

Frontiers in Photonics

Frontiers in Physics

Frontiers in Physiology

Frontiers in Plant Science

Frontiers in Political Science

Frontiers in Psychiatry

Frontiers in Psychology

Frontiers in Public Health

Frontiers in Quantum Science and Technology

Frontiers in RNA Research

Frontiers in Radiology

Frontiers in Rehabilitation Sciences

Frontiers in Remote Sensing

Frontiers in Reproductive Health

Frontiers in Research Metrics and Analytics

Frontiers in Robotics and AI

Frontiers in Science

Frontiers in Sensors

Frontiers in Signal Processing

Frontiers in Sleep

Frontiers in Smart Grids

Frontiers in Sociology

Frontiers in Soft Matter

Frontiers in Soil Science

Frontiers in Space Technologies

Frontiers in Sports and Active Living

Frontiers in Stroke

Frontiers in Surgery

Frontiers in Sustainability

Frontiers in Sustainable Cities

Frontiers in Sustainable Energy Policy

Frontiers in Sustainable Food Systems

Frontiers in Sustainable Resource Management

Frontiers in Sustainable Tourism

Frontiers in Synaptic Neuroscience

Frontiers in Systems Biology

Frontiers in Systems Neuroscience

Frontiers in Thermal Engineering

Frontiers in Toxicology

Frontiers in Transplantation

Frontiers in Tropical Diseases

Frontiers in Urology

Frontiers in Veterinary Science

Frontiers in Virology

Frontiers in Virtual Reality

Frontiers in Water

Frontiers in the Internet of Things

Weighted Gene Co-Expression Network Analysis (WGCNA) Reveals the Functions of Syndecan-1 to Regulate Immune Infiltration by Influenced T Cells in Glioma

Content Provider	frontiers
Author	Zhong, Jiacheng Shi, Shuang Peng, Wen Liu, Bei Yang, Biao Niu, Wenyong Zhang, Biao Qin, Chuan Zhong, Dong Cui, Hongjuan Zhang, Zhengbao Sun, Xiaochuan
Abstract	Our previous studies have shown that syndecan-1(SDC1) may be a novel class of biomarkers for the diagnosis and treatment of glioma, but its specific roles and the in-depth molecular mechanism remain elusive. Here, we used Estimation of STromal and Immune cells in Malignant Tumor tissues using Expression data(ESTIMATE) algorithms and single-sample Gene Set Enrichment Analysis(ssGSEA) algorithms to evaluate the immune score of tumor samples and quantify the relative infiltration of immune cells in the tumor microenvironment(TME) respectively in different datasets obtained from the Chinese Glioma Genome Atlas and The Cancer Gene Atlas. Next, we calculate the correlation of the immune score and immune cells with SDC1 respectively. To identify the specific process regulated by SDC1, the differentially expressed genes(DEGs) analysis between the high and low expression of SDC1 of glioma samples were used to discover the hub genes through Weighted Gene Coexpression Network Analysis(WGCNA). Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis revealed cardinal biological processes and pathways involved in genes and tumor grade correlation and survival analysis verified its significance in glioma. The results showed that SDC1 is associated with the immune infiltration of glioma in the tumor microenvironment, especially activated CD4+T cells and CD8+T cells. The three datasets filter 8887 differentially expressed genes, the genes in the blue modules were selected as hub genes in WGCNA. GO and KEGG analysis found 8 genes in the blue modules involved in antigen processing and presentation in T cells in glioma. Kaplan-Meier estimator and Log-rank test statistic determined that the introduced genes are associated with poor prognosis in glioma. Protein-protein network interaction analysis (PPI) showed that SDC1 may regulate antigen processing and presentation through CTSL or CD4 in glioma. Finally, this study provided insights and clues for the next research direction of SDC1 and identiﬁed the key pathways and genes, which might participate in the immune escape of glioma. These results might provide new insight into the study of immune infiltration of glioma in the future.
ISSN	16648021
DOI	10.3389/fgene.2022.792443
Volume Number	13
Journal	Frontiers in Genetics
Language	English
Publisher Date	2022-05-20
Access Restriction	Open
Subject Keyword	WGCNA Syndecan-1 Immune infiltration Tumor Microenvironment Glioma
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Medicine Genetics (clinical)

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in