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| Content Provider | frontiers |
|---|---|
| Author | Qin, Zhen Xiang, Kefa Su, Ding-Feng Sun, Yang Liu, Xia |
| Abstract | The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory pathway (CAP) is a potential therapeutic strategy. However, there is currently no approved drugs targeting the regulatory pathway. It is evident that nicotine, anisodamine and some herb medicine, activate the CAP and exert anti-inflammation action in vitro and in vivo. As the vagus nerve affects both inflammation and specific immune response, we propose that vagus nerve stimulation by invasive or non-invasive devices and acupuncture at ST36, PC6, or GV20, are also feasible approaches to activate the CAP and control COVID-19. It is worth to investigate the efficacy and safety of the strategy in patients with COVID-19. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2020.595342 |
| Volume Number | 11 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2021-02-08 |
| Access Restriction | Open |
| Subject Keyword | COVID-19 Therapeutic strategy Vagus Nerve Stimulation Cholinergic anti-inflammatory pathway Cytokine storm |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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