NDLI: A scalable model for simulating multi-round antibody evolution and benchmarking of clonal tree reconstruction methods

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Year: 2023 Month: September Volume: 14

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Editorial: Updates on immunity to influenza A virus in humans and animals

Editorial: Innate immunity and severe asthma: From microbiome to target therapy

Gut mycobiome dysbiosis contributes to the development of hypertension and its response to immunoglobulin light chains

Editorial: Metabolic conditions of chronic inflammatory diseases

Placental galectins regulate innate and adaptive immune responses in pregnancy

A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration

Editorial: JAK inhibition in autoimmune and inflammatory diseases

PvML1 suppresses bacterial infection by recognizing LPS and regulating AMP expression in shrimp

Soluble TREM2 is a potential biomarker for the severity of primary angiitis of the CNS

Resistance to white spot syndrome virus in the European shore crab is associated with suppressed virion trafficking and heightened immune responses

Case report: Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders

High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes

Cuproptosis related genes associated with Jab1 shapes tumor microenvironment and pharmacological profile in nasopharyngeal carcinoma

Cdc42 regulates cytokine expression and trafficking in bronchial epithelial cells

‘Cannibalism’ of exogenous DNA sequences: The ancestral form of adaptive immunity which entails recognition of danger

MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis

Unraveling the role of Breg cells in digestive tract cancer and infectious immunity

Frequent somatic mosaicism in T lymphocyte subsets in individuals with and without multiple sclerosis

Vaccine-based clinical protection against SARS-CoV-2 infection and the humoral immune response: A 1-year follow-up study of patients with multiple sclerosis receiving ocrelizumab

Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: A narrative review

Computer-aided drug design combined network pharmacology to explore anti-SARS-CoV-2 or anti-inflammatory targets and mechanisms of Qingfei Paidu Decoction for COVID-19

No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment

Co-expression of fibrotic genes in inflammatory bowel disease; A localized event?

Characteristics of macrophage-like cells in acute nonarteritic anterior ischemic optic neuropathy and the normal fellow eyes on en face optical coherence tomography

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors

Clinical cure rate of inactive HBsAg carriers with HBsAg <200 IU/ml treated with pegylated interferon

Gut microbiota: The key to the treatment of metabolic syndrome in traditional Chinese medicine – a case study of diabetes and nonalcoholic fatty liver disease

Case report: A report of the complete pathological response of intrahepatic cholangiocarcinoma after conversion therapy

Interleukin-15 and chemokine ligand 19 enhance cytotoxic effects of chimeric antigen receptor T cells using zebrafish xenograft model of gastric cancer

Prognostic value of TMEM59L and its genomic and immunological characteristics in cancer

Hcp1-loaded staphylococcal membrane vesicle vaccine protects against acute melioidosis

Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response

Effect of dietary soybean saponin Bb on the growth performance, intestinal nutrient absorption, morphology, microbiota, and immune response in juvenile Chinese soft-shelled turtle (Pelodiscus sinensis)

Comprehensive analysis of a glycolysis and cholesterol synthesis-related genes signature for predicting prognosis and immune landscape in osteosarcoma

High-intensity chemotherapy improved the prognosis of patients with high-grade B-cell lymphoma

TRPV4 activation prevents lipopolysaccharide-induced painful bladder hypersensitivity in rats by regulating immune pathways

Long-term sialidase-specific immune responses after natural infection with cholera: Findings from a longitudinal cohort study in Bangladesh

Targeting cancer-specific metabolic pathways for developing novel cancer therapeutics

New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies

Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses

NR4A2 may be a potential diagnostic biomarker for myocardial infarction: A comprehensive bioinformatics analysis and experimental validation

CCR7/dendritic cell axis mediates early bacterial dissemination in Orientia tsutsugamushi-infected mice

Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system

Platelet abnormalities in autoimmune thyroid diseases: A systematic review and meta-analysis

Resting time after phorbol 12-myristate 13-acetate in THP-1 derived macrophages provides a non-biased model for the study of NLRP3 inflammasome

Single-cell RNA sequencing to dissect the immunological network of liver fibrosis in Schistosoma japonicum-infected mice

Multi-omics analyses of tumor-associated immune-infiltrating cells with the novel immune checkpoint protein tyrosine phosphatase 1B (PTP1B) in extracellular matrix of brain-lower-grade-glioma (LGG) and uveal-melanoma (UVM)

SARS-CoV-2 booster vaccination rescues attenuated IgG1 memory B cell response in primary antibody deficiency patients

Time to consider sequencing anti-inflammatory treatments with chemotherapy and immuno-stimulation?

Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment

Serum cytokine profiling reveals different immune response patterns during general and severe Mycoplasma pneumoniae pneumonia

Inflammatory checkpoints in amyotrophic lateral sclerosis: From biomarkers to therapeutic targets

A pan-cancer and single-cell sequencing analysis of CD161, a promising onco-immunological biomarker in tumor microenvironment and immunotherapy

Chimeric antigen receptor T-cell therapy for multiple myeloma

Integrated analysis of necroptosis-related genes for evaluating immune infiltration and colon cancer prognosis

Variations in dynamic tumor-associated antigen-specific T cell responses correlate with HCC recurrence after thermal ablation

AbAgIntPre: A deep learning method for predicting antibody-antigen interactions based on sequence information

CARMA3: A potential therapeutic target in non-cancer diseases

Advances in pathogenesis and nanoparticles (NPs)-mediated treatment of psoriasis

Editorial: Deciphering the role of macrophages in lung homeostasis and diseases

MiR-451a and let-7i-5p loaded extracellular vesicles attenuate heme-induced inflammation in hiPSC-derived endothelial cells

Manipulating T-cell metabolism to enhance immunotherapy in solid tumor

Neuroinflammation in Huntington’s disease: From animal models to clinical therapeutics

IκBNS-deficiency protects mice from fatal Listeria monocytogenes infection by blunting pro-inflammatory signature in Ly6Chigh monocytes and preventing exaggerated innate immune responses

The safety of COVID-19 vaccines in patients with myasthenia gravis: A scoping review

Arm race between Rift Valley fever virus and host

Insights into mucosal associated invariant T cell biology from human inborn errors of immunity

Epigenetics and endoplasmic reticulum in podocytopathy during diabetic nephropathy progression

Heat stress increases immune cell function in Hexacorallia

ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse

A metabolite attenuates neuroinflammation, synaptic loss and cognitive deficits induced by chronic infection of Toxoplasma gondii

Predictive model for BNT162b2 vaccine response in cancer patients based on blood cytokines and growth factors

IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma

Skin-homing basophils and beyond

Novel neutralizing chicken IgY antibodies targeting 17 potent conserved peptides identified by SARS-CoV-2 proteome microarray, and future prospects

Nomogram for predicting prognosis of patients with metastatic melanoma after immunotherapy: A Chinese population–based analysis

Epithelial-derived galectin-9 containing exosomes contribute to the immunomodulatory effects promoted by 2’-fucosyllactose and short-chain galacto- and long-chain fructo-oligosaccharides

The game between host antiviral innate immunity and immune evasion strategies of senecavirus A - A cell biological perspective

Dendritic cell-natural killer cell cross-talk modulates T cell activation in response to influenza A viral infection

Endothelial glycocalyx in hepatopulmonary syndrome: An indispensable player mediating vascular changes

CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis

A bibliometric analysis of NLRP3 inflammasome in acute lung injury/acute respiratory distress syndrome from 2010 to 2021

Increased expression of the ectoenzyme CD38 in peripheral blood plasmablasts and plasma cells of patients with systemic sclerosis

The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells

Effects of replacing fishmeal with cottonseed protein concentrate on growth performance, blood metabolites, and the intestinal health of juvenile rainbow trout (Oncorhynchus mykiss)

Pan-cancer analysis of ASB3 and the potential clinical implications for immune microenvironment of glioblastoma multiforme

Predicting the prognosis in patients with sepsis by a pyroptosis-related gene signature

When secretion turns into excretion – the different roles of IgA

A diagnostic model for predicting type 2 nasal polyps using biomarkers in nasal secretion

The role of interferons in ovarian cancer progression: Hinderer or promoter?

Polo-like kinase 1 is related with malignant characteristics and inhibits macrophages infiltration in glioma

Neutralizing antibody titers to Omicron six months after vaccination with BNT162b2 in Colombia

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model

Actin depolymerizing factor-based nanomaterials: A novel strategy to enhance E. mitis-specific immunity

Editorial: Factors determining long term anti-tumor responses to immune checkpoint blockade therapy

Chicken CSF2 and IL-4-, and CSF2-dependent bone marrow cultures differentiate into macrophages over time

In-depth analysis of T cell immunity and antibody responses in heterologous prime-boost-boost vaccine regimens against SARS-CoV-2 and Omicron variant

Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni

HLA-G 3’UTR polymorphism diplotypes and soluble HLA-G plasma levels impact cervical cancer susceptibility and prognosis

Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective

Assessing microbial manipulation and environmental pollutants in the pathogenesis of psoriasis

Systematic analysis of brain and skull ischemic injury expression profiles reveals associations of the tumor immune microenvironment and cell death with ischemic stroke

Two distinct resident macrophage populations coexist in the ovary

Embryonic ILC-poiesis across tissues

Targets for chimeric antigen receptor T-cell therapy of acute myeloid leukemia

Precision-cut rat placental slices as a model to study sex-dependent inflammatory response to LPS and Poly I:C

A novel ganglioside-related risk signature can reveal the distinct immune landscape of neuroblastoma and predict the immunotherapeutic response

Corrigendum: Clinical efficacy, safety and tolerability of a new subcutaneous immunoglobulin 16.5% (Octanorm [Cutaquig®]) in the treatment of patients with primary immunodeficiencies

HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes

Dominant-negative signal transducer and activator of transcription (STAT)3 variants in adult patients: A single center experience

Low vitamin D concentrations and BMI are causal factors for primary biliary cholangitis: A mendelian randomization study

Anti-PD-1 immune-related adverse events are associated with high therapeutic antibody fixation on T cells

The 2000HIV study: Design, multi-omics methods and participant characteristics

Complement component 3 protects human bronchial epithelial cells from cigarette smoke-induced oxidative stress and prevents incessant apoptosis

Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function

Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation

Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma

A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedema

Cancer risks in rheumatoid arthritis patients who received immunosuppressive therapies: Will immunosuppressants work?

Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer

Editorial: Engineered immune cells in cancer immunotherapy (EICCI)

Corrigendum: Advances in CAR T-cell therapy in bile duct, pancreatic, and gastric cancers

The HLA class-II immunopeptidomes of AAV capsids proteins

Explaining the polarized macrophage pool during murine allergic lung inflammation

Study of epirubicin sustained–release chemoablation in tumor suppression and tumor microenvironment remodeling

Topical Skullcapflavone II attenuates atopic dermatitis in a mouse model by directly inhibiting associated cytokines in different cell types

Obeticholic acid and 5β-cholanic acid 3 exhibit anti-tumor effects on liver cancer through CXCL16/CXCR6 pathway

Immune suppression of vaccine-induced CD8+ T-cell responses by gamma retrovirus envelope is mediated by interleukin-10-producing CD4+ T cells

Immune dysfunctions affecting bone marrow Vγ9Vδ2 T cells in multiple myeloma: Role of immune checkpoints and disease status

Uncovering a 500 million year old history and evidence of pseudogenization for TLR15

Oral supplementation with yeast β-glucans improves the resolution of Escherichia coli-associated inflammatory responses independently of monocyte/macrophage immune training

Corrigendum: Mettl14-mediated m6A modification enhances the function of Foxp3+ regulatory T cells and promotes allograft acceptance

Can vitamin D status influence seroconversion to SARS-COV2 vaccines?

TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy

Reverse causal relationship between periodontitis and shortened telomere length: Bidirectional two-sample Mendelian random analysis

Determinants of long COVID among adults hospitalized for SARS-CoV-2 infection: A prospective cohort study

Aryl hydrocarbon receptor: The master regulator of immune responses in allergic diseases

Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease

The role of lncRNAs in the tumor microenvironment and immunotherapy of melanoma

The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease

Editorial: B cell heterogeneity in the single-cell era

CLIC-01: Manufacture and distribution of non-cryopreserved CAR-T cells for patients with CD19 positive hematologic malignancies

Macrophages and γδ T cells interplay during SARS-CoV-2 variants infection

Editorial: Frontiers on innate immunity and intercellular communication

Construction of prediction model of inflammation related genes in idiopathic pulmonary fibrosis and its correlation with immune microenvironment

PD-1/PD-L1 checkpoint inhibitors in advanced hepatocellular carcinoma immunotherapy

Interplay of four types of RNA modification writers revealed distinct tumor microenvironment and biological characteristics in pancreatic cancer

Appropriate level of cuproptosis may be involved in alleviating pulmonary fibrosis

Focusing on NK cells and ADCC: A promising immunotherapy approach in targeted therapy for HER2-positive breast cancer

Radiomic models based on magnetic resonance imaging predict the spatial distribution of CD8+ tumor-infiltrating lymphocytes in breast cancer

Neurotrophic and immunomodulatory effects of olfactory ensheathing cells as a strategy for neuroprotection and regeneration

Case report: Variable response to immunotherapy in ovarian cancer: Our experience within the current state of the art

Early calcineurin-inhibitor to belatacept conversion in steroid-free kidney transplant recipients

Reversal of splicing infidelity is a pre-activation step in B cell differentiation

Circulating brain-derived extracellular vesicles expressing neuroinflammatory markers are associated with HIV-related neurocognitive impairment

Delineating the molecular landscape of different histopathological growth patterns in colorectal cancer liver metastases

Piperlongumine alleviates corneal allograft rejection via suppressing angiogenesis and inflammation

The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response

Care of patients with inborn errors of immunity in thirty J Project countries between 2004 and 2021

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling

Immunomodulatory role of metalloproteases in cancers: Current progress and future trends

EGFR-targeted bacteriophage lambda penetrates model stromal and colorectal carcinoma tissues, is taken up into carcinoma cells, and interferes with 3-dimensional tumor formation

cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus

A transient receptor potential channel-related model based on machine learning for evaluating tumor microenvironment and immunotherapeutic strategies in acute myeloid leukemia

Expounding the role of tick in Africa swine fever virus transmission and seeking effective prevention measures: A review

Efficacy and safety of neoadjuvant immunotherapy in resectable esophageal or gastroesophageal junction carcinoma: A pooled analysis of prospective clinical trials

Editorial: Macrophage immunity and metabolism in cancer: Novel diagnostic and therapeutic strategies

Detrimental effects of simulated microgravity on mast cell homeostasis and function

Tumor necrosis factor-α-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model

Behavioral factors to modulate immunotherapy efficacy in cancer

Impact of neutrophil extracellular traps on fluid properties, blood flow and complement activation

Density dependent regulation of inflammatory responses in macrophages

Editorial: Systemic lupus erythematosus - predisposition factors, pathogenesis, diagnosis, treatment and disease models

A bibliometric analysis of autophagy in lung diseases from 2012 to 2021

The relationship between chronic immune response and neurodegenerative damage in long COVID-19

Pasteurella multocida toxin – lessons learned from a mitogenic toxin

The impact on colostrum oxidative stress, cytokines, and immune cells composition after SARS-CoV-2 infection during pregnancy

Substitutions at position 263 within the von Willebrand factor type A domain determine the functionality of complement C2 protein

Association of the systemic immune-inflammation index (SII) and clinical outcomes in patients with stroke: A systematic review and meta-analysis

Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations

Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies

Prospects for NK-based immunotherapy of chronic HBV infection

Mucosa associated invariant T and natural killer cells in active and budesonide treated collagenous colitis patients

In or out of control: Modulating regulatory T cell homeostasis and function with immune checkpoint pathways

Infiltration of LPAR5+ macrophages in osteosarcoma tumor microenvironment predicts better outcomes

Prognostic prediction and immune infiltration analysis based on ferroptosis and EMT state in hepatocellular carcinoma

Comparison of different gene addition strategies to modify placental derived-mesenchymal stromal cells to produce FVIII

Histone lysine-specific demethylase 1 regulates the proliferation of hemocytes in the oyster Crassostrea gigas

Can G-quadruplex become a promising target in HBV therapy?

Exposure to particulate pollutant increases the risk of hospitalizations for Sjögren’s syndrome

HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites

Oral administration of hepcidin and chitosan benefits growth, immunity, and gut microbiota in grass carp (Ctenopharyngodon idella)

Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis

Reinventing the human tuberculosis (TB) granuloma: Learning from the cancer field

The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis

Targeting heat shock proteins 90 and 70: A promising remedy for both autoimmune bullous diseases and COVID-19

Longitudinal immune profiling after radiation-attenuated sporozoite vaccination reveals coordinated immune processes correlated with malaria protection

Transcriptome profiling of osteoclast subsets associated with arthritis: A pathogenic role of CCR2hi osteoclast progenitors

Immune-based combination therapy for esophageal cancer

Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS

The BNT162b2 vaccine induces humoral and cellular immune memory to SARS-CoV-2 Wuhan strain and the Omicron variant in children 5 to 11 years of age

Characteristics of the immunogenicity and tumor immune microenvironment in HER2-amplified lung adenocarcinoma

Cysteine-specific 89Zr-labeled anti-CD25 IgG allows immuno-PET imaging of interleukin-2 receptor-α on T cell lymphomas

The blood pressure targets in sepsis patients with acute kidney injury: An observational cohort study of multiple ICUs

cGAS in nucleus: The link between immune response and DNA damage repair

Immune-related adverse events: A bibliometric analysis

Phenotypic alteration of low-density granulocytes in people with pulmonary post-acute sequelae of SARS-CoV-2 infection

Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

Immunity: Psoriasis comorbid with atherosclerosis

Immune system modulation in aging: Molecular mechanisms and therapeutic targets

The diagnosis of anti-LGI1 encephalitis varies with the type of immunodetection assay and sample examined

The extrinsic factors important to the homeostasis of allergen-specific memory CD4 T cells

Essential immune functions of fibroblasts in innate host defense

A new framework for host-pathogen interaction research

Evaluation of dendritic cell-targeting T7 phages as a vehicle to deliver avian influenza virus H5 DNA vaccine in SPF chickens

Transcriptional inhibition of STAT1 functions in the nucleus alleviates Th1 and Th17 cell-mediated inflammatory diseases

Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort

Specificity of CD200/CD200R pathway in LPS-induced lung inflammation

TLR7 agonism accelerates disease in a mouse model of primary Sjögren’s syndrome and drives expansion of T-bet+ B cells

3D tumor explant as a novel platform to investigate therapeutic pathways and predictive biomarkers in cancer patients

COVID-19 and monkeypox co-infection: A rapid systematic review

Corrigendum: Editorial: Immunological role of the maternal microbiome in pregnancy

Risk of liver dysfunction and non-alcoholic fatty liver diseases in people with hidradenitis suppurativa: A systematic review and meta-analysis of real-world evidences

Case report: Eculizumab plus obinutuzumab induction in a deceased donor kidney transplant recipient with DEAP-HUS

Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment

Fatty acid metabolism is related to the immune microenvironment changes of gastric cancer and RGS2 is a new tumor biomarker

The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus

Microglial Pten safeguards postnatal integrity of the cortex and sociability

EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation

Oxygen level is a critical regulator of human B cell differentiation and IgG class switch recombination

Association between lactate-to-albumin ratio and 28-days all-cause mortality in patients with acute pancreatitis: A retrospective analysis of the MIMIC-IV database

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

New insights into β-glucan-enhanced immunity in largemouth bass Micropterus salmoides by transcriptome and intestinal microbial composition

Case report: JAKi and TNFi dual therapy is a potential treatment strategy for difficult-to-treat rheumatoid arthritis

Assessment of immunotherapy response in intracranial malignancy using semi-automatic segmentation on magnetic resonance images

Case Report: Isolated facial and trigeminal nerve palsy without ataxia in anti-GQ1b antibody syndrome secondary to Mycoplasma pneumonia

Pan-cancer analysis of FBXW family with potential implications in prognosis and immune infiltration

Immunoproteasome inhibition attenuates experimental psoriasis

Biology and clinical relevance of follicular cytotoxic T cells

Impact of mature tertiary lymphoid structures on prognosis and therapeutic response of Epstein-Barr virus-associated gastric cancer patients

Increased CEACAM1 expression on peripheral blood neutrophils in patients with rheumatoid arthritis

Duration biased distribution of clinical and immunological phenotypes in active SLE

Impact of hepatic steatosis on treatment response of autoimmune hepatitis: A retrospective multicentre analysis

Successful treatment of dupilumab in Kimura disease independent of IgE: A case report with literature review

Ten-year population trends of immunoglobulin use, burden of adult antibody deficiency and feasibility of subcutaneous immunoglobulin (SCIg) replacement in Hong Kong Chinese

Methylation changes induced by a glycodendropeptide immunotherapy and associated to tolerance in mice

The emerging role of regulatory cell-based therapy in autoimmune disease

Mesangial cell: A hub in lupus nephritis

T cell repertoire profiling in allografts and native tissues in recipients with COVID–19 after solid organ transplantation: Insight into T cell–mediated allograft protection from viral infection

The immune landscape of high-grade brain tumor after treatment with immune checkpoint blockade

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses

Integration analysis identifies MYBL1 as a novel immunotherapy biomarker affecting the immune microenvironment in clear cell renal cell carcinoma: Evidence based on machine learning and experiments

Efficacy and safety of belimumab for the treatment of refractory childhood-onset systemic lupus erythematosus: A single-center, real-world, retrospective study

Editorial: Insights in autoimmune and autoinflammatory disorders: 2021

Altered serum human cytomegalovirus microRNA levels are common and closely associated with the inflammatory status in patients with fever

mRNA vaccines for cancer immunotherapy

Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU)

Maintenance therapy of low-dose nivolumab, S-1, and leucovorin in metastatic pancreatic adenocarcinoma with a germline mutation of MSH6: A case report

Corrigendum: CD317-Positive Immune Stromal Cells in Human “Mesenchymal Stem Cell” Populations

A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients – indications for their potential involvement in the development of Long COVID?

Immune responses to SARS-CoV-2 in vaccinated patients receiving checkpoint blockade immunotherapy for cancer

Development of an anti-CAR antibody response in SIV-infected rhesus macaques treated with CD4-MBL CAR/CXCR5 T cells

A first-in-human phase 1 study of cavrotolimod, a TLR9 agonist spherical nucleic acid, in healthy participants: Evidence of immune activation

Editorial: Host immune evasion by Mycobacterium tuberculosis: Current updates

Novel potential biomarkers for severe alcoholic liver disease

Comprehensive analysis of the amino acid metabolism-related gene signature for prognosis, tumor immune microenvironment, and candidate drugs in hepatocellular carcinoma

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

Immune-related gene-based prognostic index for predicting survival and immunotherapy outcomes in colorectal carcinoma

Proteogenomic identification of Hepatitis B virus (HBV) genotype-specific HLA-I restricted peptides from HBV-positive patient liver tissues

Editorial: Host immune response and protective immune responses during filarial infections

Engineered M2a macrophages for the treatment of osteoarthritis

Enhanced Spike-specific, but attenuated Nucleocapsid-specific T cell responses upon SARS-CoV-2 breakthrough versus non-breakthrough infections

Steroid receptor coactivators – their role in immunity

The role of inflammation in immune system of diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

MYCBP2 expression correlated with inflammatory cell infiltration and prognosis immunotherapy in thyroid cancer patients

Fatty acid composition and metabolic partitioning of α-linolenic acid are contingent on life stage in human CD3+ T lymphocytes

Corrigendum: Determination of CSF GFAP, CCN5, and vWF levels enhances the diagnostic accuracy of clinically defined MS from non-MS patients with CSF oligoclonal bands

The role of immune cells in modulating chronic inflammation and osteonecrosis

N6-methyladenosine modification of viral RNA and its role during the recognition process of RIG-I-like receptors

Thrombotic microangiopathy mediates poor prognosis among lupus nephritis via complement lectin and alternative pathway activation

Corrigendum: Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects

Immune-mediated inflammatory diseases and risk of venous thromboembolism: A Mendelian randomization study

Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus

Diagnostic model constructed by nine inflammation-related genes for diagnosing ischemic stroke and reflecting the condition of immune-related cells

Diagnostic gene signatures and aberrant pathway activation based on m6A methylation regulators in rheumatoid arthritis

Editorial: Updates on the role of surfactant proteins A and D in innate immune responses

Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings

Using mass cytometry for the analysis of samples of the human airways

Serum uric acid as a risk factor for rejection after deceased donor kidney transplantation: A mono-institutional analysis of paired kidneys

Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression

Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model

Prevalence of parent-reported food allergy among children in China: A population-based cross-sectional survey

Machine learning-based predictive and risk analysis using real-world data with blood biomarkers for hepatitis B patients in the malignant progression of hepatocellular carcinoma

The intragraft vascularized bone marrow induces secondary donor-specific mystacial pad allograft tolerance

Basophils from allergy to cancer

Efficacy and safety of rituximab treatment in patients with idiopathic inflammatory myopathies: A systematic review and meta-analysis

Tumor necrosis factor is a necroptosis-associated alarmin

The role behind the scenes of Tregs and Th17s in Hashimoto’s thyroiditis: Toward a pivotal role of FOXP3 and BACH2

Serological, fragmentomic, and epigenetic characteristics of cell-free DNA in patients with lupus nephritis

Mendelian randomization study reveals a causal relationship between rheumatoid arthritis and risk for pre-eclampsia

Circulating monocytes in acute pancreatitis

Comprehensive assessment of SARS-CoV-2 antibodies against various antigenic epitopes after naive COVID-19 infection and vaccination (BNT162b2 or ChAdOx1 nCoV-19)

Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1

Virus-like particles containing a prefusion-stabilized F protein induce a balanced immune response and confer protection against respiratory syncytial virus infection in mice

Optimizing an immunomodulatory potency assay for Mesenchymal Stromal Cell

Longevity of memory B cells and antibodies, as well as the polarization of effector memory helper T cells, are associated with disease severity in patients with COVID-19 in Bangladesh

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Innate immune function during antineoplastic treatment is associated with 12-months survival in non-small cell lung cancer

Derivation and external validation of dendritic cell-related gene signatures for predicting prognosis and immunotherapy efficacy in bladder urothelial carcinoma

Case report: Mafb promoter activity may define the alveolar macrophage dichotomy

Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b

Development and validation of the prognostic model based on autophagy-associated genes in idiopathic pulmonary fibrosis

SOX chemotherapy with anti-PD-1 and iNKT cell immunotherapies for stage IV gastric adenocarcinoma with liver metastases: A case report

Pam2CSK4-adjuvanted SARS-CoV-2 RBD nanoparticle vaccine induces robust humoral and cellular immune responses

Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Bidirectional associations between eosinophils, basophils, and lymphocytes with atopic dermatitis: A multivariable Mendelian randomization study

Inflammatory-driven NK cell maturation and its impact on pathology

The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance

Potent immunomodulatory and antitumor effect of anti-CD20-IL2no-alpha tri-functional immunocytokine for cancer therapy

Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood

Residual tumor model in esophageal squamous cell carcinoma after neoadjuvant immunochemotherapy: Frequently involves the mucosa and/or submucosa

Editorial: Lactate metabolism and regulation of the immune response

HBD-2 variants and SARS-CoV-2: New insights into inter-individual susceptibility

Editorial: The mechanism and novel strategies of overcoming resistance of hematological malignancies to CAR-T cell killing

Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection

Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis

A bias of Asparagine to Lysine mutations in SARS-CoV-2 outside the receptor binding domain affects protein flexibility

Assessment and impact of dose escalation on anti-drug antibodies in Fabry disease

Efficacy of immune checkpoint inhibitors plus molecular targeted agents after the progression of lenvatinib for advanced hepatocellular carcinoma

Association of antithrombin with development of trauma-induced disseminated intravascular coagulation and outcomes

Molecular and anatomical roadmap of stroke pathology in immunodeficient mice

Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease

Case report: A new pathogenic variant of LRBA deficiency with a complex phenotype and Rosai-Dorfman disease

Dysregulation of the immune response in TGF-β signalopathies

Myeloid-derived suppressor cell: A crucial player in autoimmune diseases

Sex differences in Guillain Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and experimental autoimmune neuritis

Exploring biomarkers for prognosis and neoadjuvant chemosensitivity in rectal cancer: Multi-omics and ctDNA sequencing collaboration

A novel technology for home monitoring of lupus nephritis that tracks the pathogenic urine biomarker ALCAM

Molecular characterization of immunogenic cell death indicates prognosis and tumor microenvironment infiltration in osteosarcoma

Omicron variants of SARS-CoV-2 and long COVID

Editorial: Signaling pathways behind immune evasion and therapy resistance

Humoral immune response following a third SARS-CoV-2 mRNA vaccine dose in solid organ transplant recipients compared with matched controls

Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing

Protective role of engineered extracellular vesicles loaded quercetin nanoparticles as anti-viral therapy against SARS-CoV-2 infection: A prospective review

Edible plant extracellular vesicles: An emerging tool for bioactives delivery

Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applications

Time-restricted feeding reduces monocyte production by controlling hematopoietic stem and progenitor cells in the bone marrow during obesity

Successful treatment of rituximab-unresponsive elderly-onset neuromyelitis optica spectrum disorder and hypogammaglobulinemia with ofatumumab plus intravenous immunoglobulin therapy in a patient with mutant FCGR3A genotype: A case report

Corrigendum: Peripheral blood lymphocyte subsets predict the efficacy of immune checkpoint inhibitors in non– small cell lung cancer

Isolation, structures, bioactivities, application and future prospective for polysaccharides from Tremella aurantialba: A review

Editorial: DADA2 and other monogenic vasculitides

Editorial: The interaction of NKG2D and its ligands in health and diseases

Case report: Persistent shedding of a live vaccine-derived rubella virus in a young man with severe combined immunodeficiency and cutaneous granuloma

Prognosis of hyperviscosity syndrome in newly diagnosed multiple myeloma in modern-era therapy: A real-life study

Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation

Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection

The single-cell landscape of cystic echinococcosis in different stages provided insights into endothelial and immune cell heterogeneity

Decidual macrophages in recurrent spontaneous abortion

Both N- and C-terminal domains of galectin-9 are capable of inducing HIV reactivation despite mediating differential immunomodulatory functionalities

JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review

Overnutrition-induced gout: An immune response to NLRP3 inflammasome dysregulation by XOD activity increased in quail

How GRAIL controls Treg function to maintain self-tolerance

Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis

Involvement of the STING signaling in COVID-19

Probiotic effects on immunity and microbiome in HIV-1 discordant patients

Commentary: Systemic lupus erythematosus and cardiovascular disease: A Mendelian randomization study

Impact of Kawasaki disease on juvenile idiopathic arthritis in real-world patients: A population-based cohort study

Chickens, more than humans, focus the diversity of their immunoglobulin genes on the complementarity-determining region but utilise amino acids, indicative of a more cross-reactive antibody repertoire

Myomedin replicas of gp120 V3 loop glycan epitopes recognized by PGT121 and PGT126 antibodies as non-cognate antigens for stimulation of HIV-1 broadly neutralizing antibodies

Neoadjuvant immunotherapy for resectable esophageal cancer: A review

Combination TIGIT/PD-1 blockade enhances the efficacy of neoantigen vaccines in a model of pancreatic cancer

Corrigendum: Bibliometric and visual analysis of neutrophil extracellular traps from 2004 to 2022

Precision medicine: The use of tailored therapy in primary immunodeficiencies

Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities

Upregulated antimicrobial immune response mediated by neutrophils in the development from allergic rhinitis to asthma

Integrative transcriptomic analysis in human and mouse model of anaphylaxis identifies gene signatures associated with cell movement, migration and neuroinflammatory signalling

Preclinical evaluation of safety and immunogenicity of a primary series intranasal COVID-19 vaccine candidate (BBV154) and humoral immunogenicity evaluation of a heterologous prime-boost strategy with COVAXIN (BBV152)

Immunogenicity and safety of an inactivated enterovirus 71 vaccine coadministered with trivalent split-virion inactivated influenza vaccine: A phase 4, multicenter, randomized, controlled trial in China

Dupilumab improves clinical symptoms in children with Netherton syndrome by suppressing Th2-mediated inflammation

Identification of immune microenvironment subtypes and signature genes for Alzheimer’s disease diagnosis and risk prediction based on explainable machine learning

Patients with positive HER-2 amplification advanced gastroesophageal junction cancer achieved complete response with combined chemotherapy of AK104/cadonilimab (PD-1/CTLA-4 bispecific): A case report

Pathogen spectrum and immunotherapy in patients with anti-IFN-γ autoantibodies: A multicenter retrospective study and systematic review

Hemophilia a patients with inhibitors: Mechanistic insights and novel therapeutic implications

Comparison between Lactobacillus rhamnosus GG and LuxS-deficient strain in regulating gut barrier function and inflammation in early-weaned piglets

A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production

Age of onset correlates with clinical characteristics and prognostic outcomes in neuromyelitis optica spectrum disorder

Trickle infection with Heligmosomoides polygyrus results in decreased worm burdens but increased intestinal inflammation and scarring

Enhancing CAR T-cell therapies against solid tumors: Mechanisms and reversion of resistance

Genome-wide DNA methylation of Munro’s microabscess reveals the epigenetic regulation in the pathogenesis of psoriasis

Corrigendum: Decreased expression of programmed death ligand-L1 by seven in absentia homolog 2 in cholangiocarcinoma enhances T-cell–mediated antitumor activity

Plasma cell subtypes analyzed using artificial intelligence algorithm for predicting biochemical recurrence, immune escape potential, and immunotherapy response of prostate cancer

Chronic CD40L blockade is required for long-term cardiac allograft survival with a clinically relevant CTLA4-Ig dosing regimen

Pasture intake protects against commercial diet-induced lipopolysaccharide production facilitated by gut microbiota through activating intestinal alkaline phosphatase enzyme in meat geese

Serious adverse events and coping strategies of CAR-T cells in the treatment of malignant tumors

Sintilimab plus autologous NK cells as second-line treatment for advanced non-small-cell lung cancer previous treated with platinum-containing chemotherapy

Molecular dissection of Janus kinases as drug targets for inflammatory diseases

Vaginal neutrophil infiltration is contingent on ovarian cycle phase and independent of pathogen infection

Corrigendum: Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

Safety and short-term outcomes of laparoscopic surgery for advanced gastric cancer after neoadjuvant immunotherapy: A retrospective cohort study

Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues

Parasite infections, neuroinflammation, and potential contributions of gut microbiota

Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study

Body composition parameters for predicting the efficacy of neoadjuvant chemotherapy with immunotherapy for gastric cancer

GLP-1 receptor agonist as a modulator of innate immunity

Circulating plasmablasts and follicular helper T-cell subsets are associated with antibody-positive autoimmune epilepsy

Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2

Intraepithelial lymphocytes in the pig intestine: T cell and innate lymphoid cell contributions to intestinal barrier immunity

Different local, innate and adaptive immune responses are induced by two commercial Mycoplasma hyopneumoniae bacterins and an adjuvant alone

Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer

The CMV-encoded G protein-coupled receptors M33 and US28 play pleiotropic roles in immune evasion and alter host T cell responses

The immunological role of mesenchymal stromal cells in patients with myelodysplastic syndrome

IL-21 signaling promotes the establishment of KSHV infection in human tonsil lymphocytes by increasing differentiation and targeting of plasma cells

Inhibiting the inflammasome with MCC950 counteracts muscle pyroptosis and improves Duchenne muscular dystrophy

Bile acids as inflammatory mediators and modulators of intestinal permeability

Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation

Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis

Clinical relevance of genetic polymorphisms in WNT signaling pathway (SFRP1, WNT3A, CTNNB1, WIF-1, DKK-1, LRP5, LRP6) on pulmonary tuberculosis in a Chinese population

Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers

Protein re-surfacing of E. coli L-Asparaginase to evade pre-existing anti-drug antibodies and hypersensitivity responses

An immune risk score predicts progression-free survival of melanoma patients in South China receiving anti-PD-1 inhibitor therapy—a retrospective cohort study examining 66 circulating immune cell subsets

Effect of inactivated COVID-19 vaccines on seizure frequency in patients with epilepsy: A multicenter, prospective study

B21 DNA vaccine expressing ag85b, rv2029c, and rv1738 confers a robust therapeutic effect against latent Mycobacterium tuberculosis infection

HIF-1α/BNIP3L induced cognitive deficits in a mouse model of sepsis-associated encephalopathy

Circulatory levels of alarmins in patients with non-segmental vitiligo: Potential biomarkers for disease diagnosis and activity/severity assessment

Research progress on the role of hormones in ischemic stroke

Targeting T-cell metabolism to boost immune checkpoint inhibitor therapy

Corrigendum: Sulforaphane promotes dendritic cell stimulatory capacity through modulation of regulatory molecules, JAK/STAT3- and microRNA-signaling

Progress of cGAS-STING signaling in response to SARS-CoV-2 infection

PD-1/PD-L1 inhibitors plus anti-angiogenic agents with or without chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy as second or later-line treatment for patients with advanced non-small cell lung cancer: A real-world retrospective cohort study

Cooperation between cGAS and RIG-I sensing pathways enables improved innate recognition of HIV-1 by myeloid dendritic cells in elite controllers

Upregulation of leucine-rich alpha-2 glycoprotein: A key regulator of inflammation and joint fibrosis in patients with severe knee osteoarthritis

Identification of B cell marker genes based on single-cell sequencing to establish a prognostic model and identify immune infiltration in osteosarcoma

Pyruvate: Ferredoxin oxidoreductase is involved in IgA-related microbiota dysbiosis and intestinal inflammation

The study of neural antibodies in neurology: A practical summary

Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation

Development and function of natural TCR+ CD8αα+ intraepithelial lymphocytes

Lymphoid tissue residency: A key to understand Tcf-1+PD-1+ T cells

The role of metabolism on regulatory T cell development and its impact in tumor and transplantation immunity

Dengue induces iNOS expression and nitric oxide synthesis in platelets through IL-1R

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis

Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase

Editorial: Immune cells and inflammatory mediators in mucosal pathologies, volume II

A scalable model for simulating multi-round antibody evolution and benchmarking of clonal tree reconstruction methods

Editorial: Immunology of machine perfused organs and tissues

Anti-PD-1 antibodies, a novel treatment option for advanced chemoresistant pulmonary lymphoepithelioma carcinoma

B7 family protein glycosylation: Promising novel targets in tumor treatment

BAFF blockade attenuates acute graft-versus-host disease directly via the dual regulation of T- and B-cell homeostasis

A therapeutic vaccine strategy to prevent Pneumocystis pneumonia in an immunocompromised host in a non-human primate model of HIV and Pneumocystis co-infection

NF-κB-mediated anti-inflammatory effects of an organic light-emitting diode (OLED) device in lipopolysaccharide (LPS)-induced in vitro and in vivo inflammation models

Establishment of the immunological self in juvenile Patiria pectinifera post-metamorphosis

Age-dependent nasal immune responses in non-hospitalized bronchiolitis children

Editorial: Stromal and immune microenvironment in breast cancer metastasis

Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy

Natural killer cells induce HIV-1 latency reversal after treatment with pan-caspase inhibitors

Editorial: Primary membranous nephropathy

Tear-derived exosomal biomarkers of Graves’ ophthalmopathy

Genome-wide identification of antisense lncRNAs and their association with susceptibility to Flavobacterium psychrophilum in rainbow trout

Circulating methylation level of HTR2A is associated with inflammation and disease activity in rheumatoid arthritis

Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progression

Genetic engineering of pigs for xenotransplantation to overcome immune rejection and physiological incompatibilities: The first clinical steps

NetTCR-2.1: Lessons and guidance on how to develop models for TCR specificity predictions

Monoclonal antibodies in the management of asthma: Dead ends, current status and future perspectives

Graphene quantum dots induce cascadic apoptosis via interaction with proteins associated with anti-oxidation after endocytosis by Trypanosoma brucei

Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention

Role of metalloproteases in the CD95 signaling pathways

Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma

Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma

The role of PD-1/PD-L1 axis in idiopathic pulmonary fibrosis: Friend or foe?

Evaluating IL-6 and IL-10 as rapid diagnostic tools for Gram-negative bacteria and as disease severity predictors in pediatric sepsis patients in the intensive care unit

Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy

High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells

COVID-19 vaccinology landscape in Africa

Combining PD-1 or PD-L1 inhibitors with chemotherapy is a good strategy for the treatment of extensive small cell lung cancer: A retrospective analysis of clinical studies

Identification of necroptosis-related subtypes, development of a novel signature, and characterization of immune infiltration in colorectal cancer

Overexpression of SMS in the tumor microenvironment is associated with immunosuppression in hepatocellular carcinoma

Correlation of the TIGIT-PVR immune checkpoint axis with clinicopathological features in triple-negative breast cancer

Autoimmunity in monogenic combined immune deficiencies with associated or syndromic features

Pathological complete response after neoadjuvant immunotherapy combined with chemotherapy in pediatric rectal carcinoma: A case report

A rare loss-of-function genetic mutation suggest a role of dermcidin deficiency in hidradenitis suppurativa pathogenesis

Disparities in inflammation between non-Hispanic black and white individuals with lung cancer in the Greater Chicago Metropolitan area

Analysis of m7G methylation modification patterns and pulmonary vascular immune microenvironment in pulmonary arterial hypertension

Quantitative spatial evaluation of tumor-immune interactions in the immunotherapy setting of metastatic melanoma lymph nodes

Temporally integrated transcriptome analysis reveals ASFV pathology and host response dynamics

Boolean modeling reveals that cyclic attractors in macrophage polarization serve as reservoirs of states to balance external perturbations from the tumor microenvironment

Intracerebral opportunistic infections caused by immunosuppressants after orthotopic liver transplantation: Report of two cases and literature review

Establishment and validation of a carbohydrate metabolism-related gene signature for prognostic model and immune response in acute myeloid leukemia

Transcriptomic FHITlow/pHER2high signature as a predictive factor of outcome and immunotherapy response in non-small cell lung cancer

NAFLD and HBV interplay - related mechanisms underlying liver disease progression

Milestones in acute GVHD pathophysiology

A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice

IRF2 is required for development and functional maturation of human NK cells

Viral infectious diseases severity: co-presence of transcriptionally active microbes (TAMs) can play an integral role for disease severity

Case report: A case of duodenal adenocarcinoma achieving significantly long survival treating with immune checkpoint inhibitors and chemotherapy without positive biomarkers

Design and performance characteristics of the Elecsys anti-SARS-CoV-2 S assay

Commentary: Serum hepatitis B virus large and medium surface proteins as novel tools for predicting HBsAg clearance

A novel enterocyte-related 4-gene signature for predicting prognosis in colon adenocarcinoma

Construction and validation of a robust prognostic model based on immune features in sepsis

Dysfunction of CCR1+ decidual macrophages is a potential risk factor in the occurrence of unexplained recurrent pregnancy loss

Autologous bone marrow-derived MSCs engineered to express oFVIII-FLAG engraft in adult sheep and produce an effective increase in plasma FVIII levels

Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIV

FCGR2C: An emerging immune gene for predicting sepsis outcome

Dissecting the role of CSF2RB expression in human regulatory T cells

Hypothesis of a potential BrainBiota and its relation to CNS autoimmune inflammation

Deciphering a mitochondria-related signature to supervise prognosis and immunotherapy in hepatocellular carcinoma

Case report: Hemophagocytic lymphohistiocytosis in a child with primary immunodeficiency infected with Talaromyces marneffei

Corrigendum: Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits

Immunological hyporesponsiveness in tuberculosis: The role of mycobacterial glycolipids

Impact of exposure to malaria and nutritional status on responses to the experimental malaria vaccine ChAd63 MVA ME-TRAP in 5-17 month-old children in Burkina Faso

Novel insight into miRNA biology and its role in the pathogenesis of systemic lupus erythematosus

IgE glycans promote anti-IgE IgG autoantibodies that facilitate IgE serum clearance via Fc Receptors

Soluble mediators of innate immunity in annelids and bivalve mollusks: A mini-review

Predicting diagnostic gene expression profiles associated with immune infiltration in patients with lupus nephritis

S1PR4 deficiency results in reduced germinal center formation but only marginally affects antibody production

A case report of hepatitis B virus reactivation 19 months after cessation of chemotherapy with rituximab

Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals

Single-cell transcriptomics reveals cell type–specific immune regulation associated with anti-NMDA receptor encephalitis in humans

Single-cell profiling of T cells uncovers a tissue-resident memory-like T-cell subset associated with bidirectional prognosis for B-cell acute lymphoblastic leukemia

Bidirectional two-sample Mendelian randomization study of causality between rheumatoid arthritis and myocardial infarction

Kinetics of free and ligand-bound atacicept in human serum

The different damage patterns of short-, middle- and long-range connections between patients with relapse-remitting multiple sclerosis and neuromyelitis optica spectrum disorder

Editorial: Dysregulation of immunity predisposing to severe COVID-19 infection

Simultaneous editing of TCR, HLA-I/II and HLA-E resulted in enhanced universal CAR-T resistance to allo-rejection

High-dimensional intravital microscopy reveals major changes in splenic immune system during postnatal development

ADAR1 promotes systemic sclerosis via modulating classic macrophage activation

Multiple sclerosis-disease modifying therapies affect humoral and T-cell response to mRNA COVID-19 vaccine

Central nervous system tumefactive demyelinating lesions: Risk factors of relapse and follow-up observations

Case report: Transfusion independence and abolition of extravascular hemolysis in a PNH patient treated with pegcetacoplan

Distinctive phenotype for HLA-E- versus HLA-A2-restricted memory CD8 αβT cells in the course of HCMV infection discloses features shared with NKG2C+CD57+NK and δ2-γδT cell subsets

CMV reactivation initiates long-term expansion and differentiation of the NK cell repertoire

Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis

STXBP3 and GOT2 predict immunological activity in acute allograft rejection

SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in RA patients through pyroptosis

Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironment

Global research landscape and trends of lung cancer immunotherapy: A bibliometric analysis

Novel organic selenium source hydroxy-selenomethionine counteracts the blood-milk barrier disruption and inflammatory response of mice under heat stress

Akkermansia muciniphila suppressing nonalcoholic steatohepatitis associated tumorigenesis through CXCR6+ natural killer T cells

Lung cancer patients with chronic obstructive pulmonary disease benefit from anti-PD-1/PD-L1 therapy

Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic metastases

Posttransplant de novo DSA and NDSA affect GvHD, OS, and DFS after haplo-HSCT in patients without pre-existing HLA antibodies of hematological malignancies

Resolvin D2 induces anti-microbial mechanisms in a model of infectious peritonitis and secondary lung infection

ATG-Fresenius increases the risk of red blood cell transfusion after kidney transplantation

Rapid response in relapsed follicular lymphoma with massive chylous ascites to anti-CD19 CAR T therapy using Piggy Bac: A case report

m5C regulator-mediated modification patterns and tumor microenvironment infiltration characterization in colorectal cancer: One step closer to precision medicine

A novel uveitis model induced by lipopolysaccharide in zebrafish

Whole-transcriptome analyses of sheep embryonic testicular cells infected with the bluetongue virus

Ensemble deep learning enhanced with self-attention for predicting immunotherapeutic responses to cancers

Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells

Visfatin is a multifaceted molecule that exerts regulation effects on inflammation and apoptosis in RAW264.7 cells and mice immune organs

Integrated bioinformatics to identify potential key biomarkers for COVID-19-related chronic urticaria

Radiotherapy induced immunogenic cell death by remodeling tumor immune microenvironment

The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications

Immune landscape-based machine-learning–assisted subclassification, prognosis, and immunotherapy prediction for glioblastoma

Modulating the tumor immune microenvironment with nanoparticles: A sword for improving the efficiency of ovarian cancer immunotherapy

Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis

Identification of renal ischemia reperfusion injury subtypes and predictive strategies for delayed graft function and graft survival based on neutrophil extracellular trap-related genes

Canagliflozin reverses Th1/Th2 imbalance and promotes podocyte autophagy in rats with membranous nephropathy

Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury

SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry

Interferon and interferon-stimulated genes in HBV treatment

COVID-19 vaccination and Atypical hemolytic uremic syndrome

Integrated analysis from multi-center studies identities m7G-derived modification pattern and risk stratification system in skin cutaneous melanoma

Assessment of a diverse panel of transmitted/founder HIV-1 infectious molecular clones in a luciferase based CD8 T-cell mediated viral inhibition assay

Clinical characteristics of myelin-oligodendrocyte glycoprotein antibody-positive pediatric autoimmune encephalitis without demyelination: A case series

The early function of cortisol in liver during Aeromonas hydrophila infection: Dynamics of the transcriptome and accessible chromatin landscapes

Case report: Brain metastasis necrosis with immune checkpoint inhibitors plus chemotherapy for advanced non-small cell lung cancer

The CARDS toxin of Mycoplasma pneumoniae induces a positive feedback loop of type 1 immune response

Prognostic model of immune checkpoint inhibitors combined with anti-angiogenic agents in unresectable hepatocellular carcinoma

Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling

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A scalable model for simulating multi-round antibody evolution and benchmarking of clonal tree reconstruction methods

Content Provider	frontiers
Author	Zhang, Chao Bzikadze, Andrey V. Safonova, Yana Mirarab, Siavash
Abstract	Affinity maturation (AM) of B cells through somatic hypermutations (SHMs) enables the immune system to evolve to recognize diverse pathogens. The accumulation of SHMs leads to the formation of clonal lineages of antibody secreting b cells that have evolved from a common naive B cell. Advances in high-throughput sequencing have enabled deep scans of B cell receptor repertoires, paving the way for reconstructing clonal trees. However, it is not clear if clonal trees, which capture microevolutionary time scales, can be reconstructed using traditional phylogenetic reconstruction methods with adequate accuracy. In fact, several clonal tree reconstruction methods have been developed to fix supposed shortcomings of phylogenetic methods. Nevertheless, no consensus has been reached regarding the relative accuracy of these methods, partially because evaluation is challenging. Benchmarking the performance of existing methods and developing better methods would both benefit from realistic models of clonal lineage evolution specifically designed for emulating B cell evolution. In this paper, we propose a model for modeling B cell clonal lineage evolution and use this model to benchmark several existing clonal tree reconstruction methods. Our model, designed to be extensible, has several features: by evolving the clonal tree and sequences simultaneously, it allows modeling selective pressure due to changes in affinity binding; it enables scalable simulations of large numbers of cells; it enables several rounds of infection by an evolving pathogen; and, it models building of memory. In addition, we also suggest a set of metrics for comparing clonal trees and for measuring their properties. Our benchmarking results show that while maximum likelihood phylogenetic reconstruction methods can fail to capture key features of clonal tree expansion if applied naively, a very simple post-processing of their results, where super short branches are contracted, leads to inferences that are better than alternative methods.
ISSN	16643224
DOI	10.3389/fimmu.2022.1014439
Volume Number	13
Journal	Frontiers in Immunology
Language	English
Publisher Date	2022-12-06
Access Restriction	Open
Subject Keyword	Clonal trees Antibody evolution Method benchmarking Joint tree and sequence evolution Birth-death models
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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