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| Content Provider | frontiers |
|---|---|
| Author | Fradin, Delphine Tost, Jorg Busato, Florence Mille, Clémence Lachaux, Fanny Deleuze, Jean-François Apter, Gisèle Benachi, Alexandra |
| Abstract | Pregnancy is a state of multiple physiological adaptations. Since methylation of DNA is an epigenetic mechanism that regulates gene expression and contributes to adaptive phenotypic variations, we investigated methylation changes in maternal blood of a longitudinal cohort of pregnant women from the first trimester of gestation to the third. Interestingly, during pregnancy, we found a gain of methylation in genes involved in morphogenesis, such as ezrin, while we identified a loss of methylation in genes promoting maternal-infant bonding (AVP and PPP1R1B). Together, our results provide insights into the biological mechanisms underlying physiological adaptations during pregnancy. |
| ISSN | 2296634X |
| DOI | 10.3389/fcell.2023.1185311 |
| Volume Number | 11 |
| Journal | Frontiers in Cell and Developmental Biology |
| Language | English |
| Publisher Date | 2023-05-22 |
| Access Restriction | Open |
| Subject Keyword | Bonding4 Immunity5. (Min.5-Max. 8 DNA Methylation1 Pregnancy2 Changes3 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology |
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