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| Content Provider | frontiers |
|---|---|
| Author | Kumar, Prashant Malik, Yashpal Singh Ganesh, Balasubramanian Rahangdale, Somnath Saurabh, Sharad Natesan, Senthilkumar Srivastava, Ashish Sharun, Khan Yatoo, Mohd. Iqbal Tiwari, Ruchi Singh, Raj Kumar Dhama, Kuldeep |
| Abstract | COVID-19, the human coronavirus disease caused by SARS-CoV-2, was reported for the first time in Wuhan, China in late 2019. COVID-19 has no preventive vaccine or proven standard pharmacological treatment, and consequently, the outbreak swiftly became a pandemic affecting more than 215 countries around the world. For the diagnosis of COVID-19, the only reliable diagnostics is a qPCR assay. Among other diagnostic tools, the CRISPR-Cas system is being investigated for rapid and specific diagnosis of COVID-19. The CRISPR-Cas-based methods diagnose SARS-CoV-2 infections within an hour. Apart from its diagnostic ability, the CRISPR-Cas system is also being assessed for antiviral therapy development; however, to date, no CRISPR-based therapy has been approved for human use. The Prophylactic Antiviral CRISPR in huMAN cells (PAC-MAN), which is a Cas 13 based strategy, has been developed against coronavirus. Although this strategy has the potential to be developed as a therapeutic modality, it may face significant challenges for approval in human clinical trials. This review is focused on describing the potential use and challenges of CRISPR-Cas based approaches for the development of rapid and accurate diagnostic technique and/or a possible therapeutic alternative for combating COVID-19. The assessment of potential risks associated with the use of CRISPR will be important for future clinical advancements. |
| ISSN | 22352988 |
| DOI | 10.3389/fcimb.2020.576875 |
| Volume Number | 10 |
| Journal | Frontiers in Cellular and Infection Microbiology |
| Language | English |
| Publisher Date | 2020-11-02 |
| Access Restriction | Open |
| Subject Keyword | SARS-CoV-2 CRISPR Coronavirus Pandemic (COVID-19) Therapeutic Diagnosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology Microbiology Microbiology (medical) |
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