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| Content Provider | frontiers |
|---|---|
| Author | Beversdorf, David Q. Anagnostou, Evdokia Hardan, Antonio Wang, Paul Erickson, Craig A. Frazier, Thomas W. Veenstra-VanderWeele, Jeremy |
| Abstract | and Sanofi-Aventis, SynapDx; in kind supports from AMO pharma and CRA; editorial honoraria from Wiley; book royalties from Springer and APPI, and has served on advisory boards at Roche and Quadrant Biosciences.Dr Hardan-Consultant for IAMA Therapeutics, Jazz Pharmaceuticals, and Beaming Health. Has equity options in Quadrant Biosciences and has an investor stake in SCAN-R LLC.Dr Wang is an employee of Clinical Research Associates, LLC Dr. Erickson-consultant to Scioto Bioscience, Forge, and Stalicla. Nothing else to report. None of my consulting is related directly to the content of this Frontiers manuscript. ABSTRACT Significant progress has been made in understanding the biology of autism spectrum disorder (ASD), providing rational hypotheses for interventions to address the core symptoms. However, clinical trials of these interventions have failed to yield positive results to date. In many of these studies, a subset of participants appear to respond well, but a significant benefit is not found in the overall intent-to-treat group. Due to the etiological heterogeneity of ASD, we anticipate that this will continue to be a challenge in future clinical trials. It will be critical to identify the patients that are most likely to respond to a treatment and to target those subjects in later phase trials. We therefore propose the explicit inclusion of "Phase 2m" as part of the pathway of clinical drug development, specifically for the development of a biomarker profile that can... |
| ISSN | 16640640 |
| DOI | 10.3389/fpsyt.2022.1079006 |
| Volume Number | 13 |
| Journal | Frontiers in Psychiatry |
| Language | English |
| Publisher Date | 2023-01-19 |
| Access Restriction | Open |
| Subject Keyword | Treatment Heterogeenity Genetics Biomarkers Autism (ASD) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
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