Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | frontiers |
|---|---|
| Author | Li, Wang Chen, Qi-Feng Huang, Tao Wu, Peihong Shen, Lujun Huang, Zi-Lin |
| Abstract | Background: As suggested in increasing studies, lncRNAs, the long non-coding RNAs, can serve as the potential cancer prognostic factors. However, the role of lncRNAs combinations in estimating overall survival (OS) for hepatocellular carcinoma (HCC) remains to be elucidated. This study aimed to construct a potent lncRNA signature related to the OS for HCC, so as to enhance the predicting accuracy of prognosis. Methods: The expression patterns of lncRNAs, together with related clinical data of 371 HCC patients were obtained base on The Cancer Genome Atlas (TCGA). Besides, the differentially expressed lncRNAs (DElncRNAs) were acquired through comparing tumor with normal samples. In addition, lncRNAs displaying significant association with OS were screened through univariate Cox regression analysis based on the least absolute shrinkage and selection operator (LASSO) algorithm. Afterwards, all cases were classified as validation or training group at the ratio of 3:7. Then, the constructed lncRNA signature had been developed and validated. Additionally, gene set enrichment analysis (GSEA) of the lncRNA model risk score was also conducted. Results: A total of 1292 DElncRNAs were identified, among which, 172 were significant in univariate Cox regression analysis. In the training group (n=263), LASSO regression analysis confirmed 11 out of the 172 DElncRNAs, including AC010547.1, AC010280.2, AC015712.7, GACAT3, AC079466.1, AC089983.1, AC051618.1, AL121721.1, LINC01747, LINC01517, and AC008750.3. Afterwards, the prognostic risk score was calculated. The constructed risk model showed significant correlation with HCC OS, with the log-rank P-value of 8.489e-9 and the hazard ratio (HR) of 3.648 (95% confidence interval [CI]: 2.238-5.945). At the same time, the area under the curve (AUC) for this lncRNA model was up to 0.846. Furthermore, this risk model was confirmed in the validation group (n=108) and the entire cohort. Moreover, pathways related to the lncRNA model risk score were confirmed by GSEA. Conclusion: The lncRNA signature is established in this study to predict the prognosis for HCC, which offers novel clinical evidence to targeted HCC treatment. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2020.00780 |
| Volume Number | 10 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2020-06-10 |
| Access Restriction | Open |
| Subject Keyword | Prognosis analysis TCGA Long non-coding RNAs Hepatocellular Carcinoma Least absolute shrinkage and selection operator |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|