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| Content Provider | frontiers |
|---|---|
| Author | van Nieuwenhuijze, Annemarie Burton, Oliver Lemaitre, Pierre Denton, Alice E. Cascalho, Ana Goodchild, Rose E. Malengier-Devlies, Bert Cauwe, Bénédicte Linterman, Michelle A. Humblet-Baron, Stephanie Liston, Adrian |
| Abstract | The nucleopore is an essential structure of the eukaryotic cell, regulating passage between the nucleus and cytoplasm. While individual functions of core nucleopore proteins have been identified, the role of other components, such as Nup210, are poorly defined. Here, through the use of an unbiased ENU mutagenesis screen for mutations effecting the peripheral T cell compartment, we identified a Nup210 mutation in a mouse strain with altered CD4 / CD8 T cell ratios. Through the generation of Nup210 knockout mice we identified Nup210 as having a T cell-intrinsic function in the peripheral homeostasis of T cells. Remarkably, despite the deep evolutionary conservation of this key nucleopore complex member, no other major phenotypes developed, with viable and healthy knockout mice. These results identify Nup210 as an important nucleopore complex component for peripheral T cells, and raise further questions of why this nucleopore component shows deep evolutionary conservation despite seemingly redundant functions in most cell types. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2018.02234 |
| Volume Number | 9 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2018-09-28 |
| Access Restriction | Open |
| Subject Keyword | CD4-Positive T-Lymphocytes Thymus Gland Spleen CD8-Positive T-Lymphocytes Nup210 Nucleopore |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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