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| Content Provider | frontiers |
|---|---|
| Author | Burgueño, Adriana L Astiz, Mariana Dagnino-Subiabre, Alexies |
| Abstract | Our physiology is modified by the environment during critical periods of development from gestational to infancy, even in some cases during adolescence. Stressful experiences are often a challenge to physiological homeostasis. Thus, when exposure to stressful experiences occurs during critical periods such as embryonic development or early life, these experiences have a "programming" effect on the health, changing the developmental trajectory and generating long-lasting changes in the structure and/or function of different organs and systems (Zambrano et al., 2016). Early life stress leads to physiological alterations, from metabolism to behavior evidenced by several studies in humans and animals. The effect of maternal starvation from preconception to early childhood, such as in the Dutch famine of World War II, or exposure to stressful events in the Holocaust, has shown associations between early stress and later obesity, and metabolic and behavioral disorders (Painter et al 2006, Roseboom et al 2006, Flory et al 2011). Research on stress has focused on understanding the mechanism of the stress response as well as the specific effects of stress on individuals, using several animal models (Jaggi et al 2011). Several of these studies have shown important features, one is that the effects of early life stress are also affecting subsequent generations through epigenetic inheritance. Epidemiological, experimental and literature review studies as those included in this collec... |
| ISSN | 1664042X |
| DOI | 10.3389/fphys.2022.1037409 |
| Volume Number | 13 |
| Journal | Frontiers in Physiology |
| Language | English |
| Publisher Date | 2022-10-12 |
| Access Restriction | Open |
| Subject Keyword | Physiology Stress Prenatal Development Postnatal |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) |
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