Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | frontiers |
|---|---|
| Author | Jiang, Pengjun Liu, Qingyuan Wu, Jun Chen, Xin Li, Maogui Li, Zhengsong Yang, Shuzhe Guo, Rui Gao, Bin Cao, Yong Wang, Shuo |
| Abstract | Objective: The aim of the present study is to investigate the potential morphological and hemodynamic risk factors related to intracranial aneurysms (IAs) rupture and establish a system to stratify the risk of IAs rupture to help the clinical decision-making. Methods: Patients admitted for single-IAs were selected from January 2012 and January 2018. A propensity score matching was conducted to match patients. The morphological parameters were obtained from high solution CTA images, and the hemodynamic parameters were obtained in accordance with the outcomes of computational fluid dynamics (CFDs) simulation. Differences in the morphologic and hemodynamic parameters were compared. The significant parameters were selected to establish a novel scoring system (Intracranial Aneurysm Rupture Score, IARS). The comparison was drawn between the discriminating accuracy of IARS and the Rupture Resemblance Score (RRS) system to verify the value of IARS. Then, a group of patients with unruptured IAs was stratified by IARS and RRS system separately and was followed up to verify the value of IARS. The outcome of different stratifications was compared. Results: The matching process yielded 167 patients in each group. Differences of statistical significance were found in length (p=0.001), perpendicular height (H) (p<0.001), aspect ratio (AR) (p<0.001), size ratio (SR) (p<0.001), deviated angle (DA) (p<0.001), normalized average wall shear stress (NWSSa) (p<0.001), wall shear stress gradient (WSSG) (p<0.001), low shear area ratio (LSAR) (p=0.01) and oscillatory shear index (OSI) (p=0.01). Logistic regression analysis demonstrated SR, DA, NWSSa, LSAR and OSI as the independent risk factors of IAs rupture. SR, DA, LSAR and OSI were finally selected to establish the IARS. Our present IARS showed a higher discriminating value (AUC 0.81 vs 0.77)in comparison with the RRS (SR, NWSSa and OSI) . After follow-up, seven patients were subject to IAs rupture. 5/26 in high-risk group stratified by IARS, yet 7/57 in high-risk group stratified by RRS. The accuracy of IARS was further verified (19.2% vs 12.3%, AUC: 0.723 vs 0.673, respectively). Conclusions: SR, DA, NWSSa, LSAR and OSI were considered the independent risk factors of IAs rupture. Our novel IARS showed higher accuracy in discriminating intracranial aneurysm rupture in comparison with RRS. |
| ISSN | 1662453X |
| DOI | 10.3389/fnins.2018.00596 |
| Volume Number | 12 |
| Journal | Frontiers in Neuroscience |
| Language | English |
| Publisher Date | 2018-09-05 |
| Access Restriction | Open |
| Subject Keyword | Intracranial Aneurysm Computational fluid dynamics Hemodynamic Morphological Rupture predicting |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|