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| Content Provider | frontiers |
|---|---|
| Author | Yao, Chenyang Hu, Na Cao, Hengyi Tang, Biqiu Zhang, Wenjing Xiao, Yuan Zhao, Youjin Gong, Qiyong Lui, Su |
| Abstract | Background: Antipsychotic medications provide limited long-term benefit to approximately 30% of schizophrenia patients. Multimodal magnetic resonance imaging (MRI) data have been used to investigate brain features between responders and nonresponders to antipsychotic treatment; however, these analytical techniques are unable to weigh the interrelationships between modalities. Here, we used multiset canonical correlation and joint independent component analysis (mCCA + jICA) to fuse MRI data to examine the shared and specific multimodal features between the patients and healthy controls (HCs) and between the responders and nonresponders. Method: Resting-state functional and structural MRI data were collected from 55 patients with drug-naïve first-episode schizophrenia (FES) and demographically-matched HCs. Based on the decrease in Positive and Negative Syndrome Scale scores from baseline to the 1-year follow-up, FES patients were divided into a responder group (RG) and a nonresponder group (NRG). Gray matter volume (GMV), fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) maps were used as features in mCCA + jICA. Results: Between FES patients and HCs, there were three modality-specific discriminative independent components (ICs) showing the difference in mixing coefficients (GMV-IC7, GMV-IC8, and fALFF-IC5). The fusion analysis indicated one modality-shared IC (GMV-IC2 and ReHo-IC2) and three modality-specific ICs (GMV-IC1, GMV-IC3, and GMV-IC6) between the RG and NRG. The right postcentral gyrus showed a significant difference in GMV features between FES patients and HCs and modality-shared features (GMV and ReHo) between responders and nonresponders. The modality-shared component findings were highlighted by GMV, mainly in the bilateral temporal gyrus and the right cerebellum associated with ReHo in the right postcentral gyrus. Conclusions: This study suggests that joint anatomical and functional features of the cortices may reflect an early pathophysiological mechanism that is related to a 1-year treatment response. |
| ISSN | 16640640 |
| DOI | 10.3389/fpsyt.2021.737179 |
| Volume Number | 12 |
| Journal | Frontiers in Psychiatry |
| Language | English |
| Publisher Date | 2021-12-01 |
| Access Restriction | Open |
| Subject Keyword | Functional MRI Schizophrenia MCCA + jICA Antipsychotic medication Treatment-resistant schizophrenia Multimodal fusion Structural MRI |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
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