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| Content Provider | frontiers |
|---|---|
| Author | Sobue, Gen |
| Abstract | Research TopicBrain Protein Aging and Dementia ControlTopic Editors:Gen Sobue, Nagoya University Graduate School of Medicine, Japan The prevention and control of dementia are challenging issues for medical sciences in the 21st century. Patients with neurodegenerative dementia including Alzheimer’s disease, dementia with Lewy bodies, and frontotemporal lobar degeneration (FTLD) share abnormalities in brain proteins such as β amyloid, tau, TDP-43, FUS, and α-synuclein, which result in physiological dysfunction, loss of interaction with functional molecules, acquisition of toxicity and pathogenicity, and propagation associated with neural circuit breakdown. However, issues concerning the aging of brain proteins and their acquisition of toxicity, the failure of neural circuits with resulting dementia, and the identification of therapeutic interventions that may prevent dementia have not been clarified. Since 2014, to address these crucial issues, we have defined toxicity-acquiring processes of functional proteins as "brain protein aging" and developed the novel research initiative "brain protein aging and dementia control" supported by a Grant-in-Aid for Scientific Research on Innovative Areas from MEXT. "Brain protein aging" may be controlled and facilitated by various factors such as degradation, excretory mechanisms, stress, inflammation, and genetic factors. The process of brain aging, the expression of neural toxicity, and the mechanism of neural circuit breakdown remains... |
| ISSN | 1662453X |
| DOI | 10.3389/fnins.2019.00029 |
| Volume Number | 13 |
| Journal | Frontiers in Neuroscience |
| Language | English |
| Publisher Date | 2019-03-12 |
| Access Restriction | Open |
| Subject Keyword | Dementia Brain Neurodegeneration Protein aging Toxicity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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