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| Content Provider | frontiers |
|---|---|
| Author | Ferrer-Ferrer, Maura Dityatev, Alexander |
| Abstract | Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a tetrapartite synapse. Here we outline the major mechanisms driving: (i) synaptogenesis by secreted extracellular scaffolding molecules, like thrombospondins (TSPs), neuronal pentraxins (NPs) and cerebellins, which respectively promote presynaptic, postsynaptic differentiation or both; (ii) maturation of synapses via reelin and integrin ligands-mediated signaling; and (iii) regulation of synaptic plasticity by ECM-dependent control of induction and consolidation of new synaptic configurations. Particularly, we focused on potential importance of activity-dependent concerted activation of multiple extracellular proteases, such as ADAMTS4/5/15, MMP9 and neurotrypsin, for permissive and instructive events in synaptic remodeling through localized degradation of perisynaptic ECM and generation of proteolytic fragments as inducers of synaptic plasticity. |
| ISSN | 16625129 |
| DOI | 10.3389/fnana.2018.00040 |
| Volume Number | 12 |
| Journal | Frontiers in Neuroanatomy |
| Language | English |
| Publisher Date | 2018-05-15 |
| Access Restriction | Open |
| Subject Keyword | Synaptic plasticity Proteolysis ADAMTS Perineuronal net Disease Thrombospondin Cerebellin MMP9 Tenascin Neuronal pentraxin Synaptogenesis Hevin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anatomy Cellular and Molecular Neuroscience |
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