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| Content Provider | frontiers |
|---|---|
| Author | Singh, Vishakha Khurana, Amit Allawadhi, Prince Banothu, Anil Kumar Bharani, Kala Kumar Weiskirchen, Ralf |
| Abstract | Programmed cell death protein 1 (PD-1)/PD-ligand (L)1, the immune checkpoint inhibitors have emerged as a promising strategy for the treatment of various diseases including chronic liver diseases (CLDs) such as hepatitis, liver injury and hepatocellular carcinoma (HCC). The role of PD-1/PD-L1 has been widely inspected in the treatment of viral hepatitis and HCC. PD-1 is known to play a crucial role in inhibiting immunological responses and stimulates self-tolerance by regulating the T-cell activity. Further, it promotes apoptosis of antigen-specific T-cells while preventing apoptosis of Treg cells. PD-L1 is a trans-membrane protein which is recognized as a co-inhibitory factor of immunological responses. Both, PD-1 and PD-L1 function together to downregulate the proliferation of PD-1 positive cells, suppress the expression of cytokines and stimulate apoptosis. Owing to the importance of PD-1/PD-L1 signaling, this review aims to summarize the potential of PD-1/PD-L1 inhibitors in CLDs along with toxicities associated with them. We have enlisted some of the important roles of PD-1/PD-L1 in CLDs, the clinically approved products and the pipelines of drugs under clinical evaluation. |
| ISSN | 16639812 |
| DOI | 10.3389/fphar.2021.790963 |
| Volume Number | 12 |
| Journal | Frontiers in Pharmacology |
| Language | English |
| Publisher Date | 2021-12-23 |
| Access Restriction | Open |
| Subject Keyword | Programmed cell death protein 1 Chronic Liver Diseases Hepatocellular Carcinoma T-cells Monoclonal antibodies Immunotherapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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