NDLI: B cell activation via immunometabolism in systemic lupus erythematosus

Please wait, while we are loading the content...

Frontiers in Aerospace Engineering

Frontiers in Aging

Frontiers in Aging Neuroscience

Frontiers in Agronomy

Frontiers in Allergy

Frontiers in Amphibian and Reptile Science

Frontiers in Analytical Science

Frontiers in Anesthesiology

Frontiers in Animal Science

Frontiers in Antennas and Propagation

Frontiers in Antibiotics

Frontiers in Applied Mathematics and Statistics

Frontiers in Aquaculture

Frontiers in Arachnid Science

Frontiers in Artificial Intelligence

Frontiers in Astronomy and Space Sciences

Frontiers in Audiology and Otology

Frontiers in Bacteriology

Frontiers in Batteries and Electrochemistry

Frontiers in Bee Science

Frontiers in Behavioral Economics

Frontiers in Behavioral Neuroscience

Frontiers in Big Data

Frontiers in Bioengineering and Biotechnology

Frontiers in Bioinformatics

Frontiers in Biomaterials Science

Frontiers in Biophysics

Frontiers in Bird Science

Frontiers in Blockchain

Frontiers in Built Environment

Frontiers in Carbon

Frontiers in Cardiovascular Medicine

Frontiers in Catalysis

Frontiers in Cell Death

Frontiers in Cell and Developmental Biology

Frontiers in Cellular Neuroscience

Frontiers in Cellular and Infection Microbiology

Frontiers in Ceramics

Frontiers in Chemical Biology

Frontiers in Chemical Engineering

Frontiers in Chemistry

Frontiers in Child and Adolescent Psychiatry

Frontiers in Climate

Frontiers in Clinical Diabetes and Healthcare

Frontiers in Coatings, Dyes and Interface Engineering

Frontiers in Cognition

Frontiers in Communication

Frontiers in Communications and Networks

Frontiers in Complex Systems

Frontiers in Computational Neuroscience

Frontiers in Computer Science

Frontiers in Conservation Science

Frontiers in Control Engineering

Frontiers in Dementia

Frontiers in Dental Medicine

Frontiers in Digital Health

Frontiers in Digital Humanities

Frontiers in Disaster and Emergency Medicine

Frontiers in Drug Delivery

Frontiers in Drug Discovery

Frontiers in Drug Safety and Regulation

Frontiers in Earth Science

Frontiers in Ecology and Evolution

Frontiers in Education

Frontiers in Electronic Materials

Frontiers in Electronics

Frontiers in Endocrinology

Frontiers in Energy Efficiency

Frontiers in Energy Research

Frontiers in Environmental Archaeology

Frontiers in Environmental Chemistry

Frontiers in Environmental Economics

Frontiers in Environmental Engineering

Frontiers in Environmental Health

Frontiers in Environmental Science

Frontiers in Epidemiology

Frontiers in Epigenetics and Epigenomics

Frontiers in Ethology

Frontiers in Food Science and Technology

Frontiers in Forests and Global Change

Frontiers in Freshwater Science

Frontiers in Fuels

Frontiers in Fungal Biology

Frontiers in Future Transportation

Frontiers in Gastroenterology

Frontiers in Genetics

Frontiers in Genome Editing

Frontiers in Geochemistry

Frontiers in Global Women's Health

Frontiers in Health Services

Frontiers in Hematology

Frontiers in High Performance Computing

Frontiers in Horticulture

Frontiers in Human Dynamics

Frontiers in Human Neuroscience

Frontiers in ICT

Frontiers in Imaging

Frontiers in Immunology

Year: 2023 Month: September Volume: 14

Year: 2023 Month: August Volume: 14

Year: 2023 Month: July Volume: 14

Year: 2023 Month: June Volume: 14

Year: 2023 Month: May Volume: 14

Editorial: Mechanisms of lymphocyte mediated cytotoxicity in health and disease

Vital roles of m5C RNA modification in cancer and immune cell biology

Therapy response in seronegative versus seropositive autoimmune encephalitis

Effect of an inactivated coronavirus disease 2019 vaccine, CoronaVac, on blood coagulation and glucose: a randomized, controlled, open-label phase IV clinical trial

A novel signature predicts prognosis and immunotherapy in lung adenocarcinoma based on cancer-associated fibroblasts

Editorial: Predictive short/long-term efficacy biomarkers and resistance mechanisms of CAR-T immunotherapy treatment

Assessment of human milk samples obtained pre and post-influenza vaccination reveals a poor boosting of seasonally-relevant, hemagglutinin-specific antibodies

The multikinase inhibitor axitinib in the treatment of advanced hepatocellular carcinoma: the current clinical applications and the molecular mechanisms

Editorial: Insights in inflammation: 2022

Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population

The impact of epigenetic modifications on allogeneic hematopoietic stem cell transplantation

Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis

Genetic diagnosis of inborn errors of immunity using clinical exome sequencing

Editorial: Recent advances in the development of vaccines against Acinetobacter baumannii

Effects of bariatric surgery on breast density in adult obese women: systematic review and meta-analysis

Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

Corrigendum: Diversity and heterogeneity in human breast cancer adipose tissue revealed at single-nucleus resolution

Leveraging T-cell receptor – epitope recognition models to disentangle unique and cross-reactive T-cell response to SARS-CoV-2 during COVID-19 progression/resolution

Emerging triboelectric nanogenerators for the prevention and monitoring of inflammation

Development of innate immune memory by non-immune cells during Staphylococcus aureus infection depends on reactive oxygen species

New insights into inflammatory memory of epidermal stem cells

Multi-functional adaptor SKAP1: regulator of integrin activation, the stop-signal, and the proliferation of T cells

Editorial: Women in autoimmune and autoinflammatory disorders

Sintilimab as maintenance treatment for local/regional recurrent esophageal squamous carcinoma after concurrent chemoradiotherapy: a single-arm Ib/II phase study

Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies

Lipid metabolism and rheumatoid arthritis

In-stent restenosis is associated with proliferative skin healing and specific immune and endothelial cell profiles: results from the RACHEL trial

Keratinocytes use FPR2 to detect Staphylococcus aureus and initiate antimicrobial skin defense

Mechanism-based target therapy in primary biliary cholangitis: opportunities before liver cirrhosis?

Mitochondrial control of innate immune responses

Radiotherapy combined with immune checkpoint inhibitors in locally advanced/metastatic esophageal squamous cell carcinoma: clinical trials, efficacy and future directions

Ferroptosis-mediated immune responses in cancer

Methylene blue reduces the serum levels of interleukin-6 and inhibits STAT3 activation in the brain and the skin of lipopolysaccharide-administered mice

Antibodies against Porphyromonas gingivalis in serum and saliva and their association with rheumatoid arthritis and periodontitis. Data from two rheumatoid arthritis cohorts in Sweden

Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice

Successful treatment of severe immune checkpoint inhibitor associated autoimmune hepatitis with basiliximab: a case report

Stapled peptide PROTAC induced significantly greater anti-PD-L1 effects than inhibitor in human cervical cancer cells

HIV-1 activates oxidative phosphorylation in infected CD4 T cells in a human tonsil explant model

Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8+ T cells

Siglec15 is a prognostic indicator and a potential tumor-related macrophage regulator that is involved in the suppressive immunomicroenvironment in gliomas

Interferon beta treatment is a potent and targeted epigenetic modifier in multiple sclerosis

Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review

Aberrant inflammasome activation as a driving force of human autoimmune skin disease

A multifactorial analysis of FAP to regulate gastrointestinal cancers progression

Leveraging a disulfidptosis-based signature to improve the survival and drug sensitivity of bladder cancer patients

Viral infection reveals hidden sharing of TCR CDR3 sequences between individuals

The role of inflammatory biomarkers in the development and progression of pre-eclampsia: a systematic review and meta-analysis

Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing

How to train your myeloid cells: a way forward for helminth vaccines?

MAPK8 and CAPN1 as potential biomarkers of intervertebral disc degeneration overlapping immune infiltration, autophagy, and ceRNA

A plasmatic score using a miRNA signature and CXCL-10 for accurate prediction and diagnosis of liver allograft rejection

Differential expression and correlation of immunoregulation related piRNA in rheumatoid arthritis

Etiology, effects and management of comorbidities in multiple sclerosis: recent advances

Identification of a potential novel biomarker in intervertebral disk degeneration by bioinformatics analysis and experimental validation

Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis

Targeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy

Machine learning analysis of humoral and cellular responses to SARS-CoV-2 infection in young adults

Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein

Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses

Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain

Cuproptosis-related gene identification and immune infiltration analysis in systemic lupus erythematosus

Construction of a fecal immune-related protein-based biomarker panel for colorectal cancer diagnosis: a multicenter study

Incidence and risk factors of acute kidney injury in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis

Differential recognition of influenza A virus H1N1 neuraminidase by DNA vaccine-induced antibodies in pigs and ferrets

Continuation of anti-PD-1 therapy plus physician-choice treatment beyond first progression is not associated with clinical benefit in patients with advanced non-small cell lung cancer

T cell receptor and B cell receptor exhibit unique signatures in tumor and adjacent non-tumor tissues of hepatocellular carcinoma

Blocking autofluorescence in brain tissues affected by ischemic stroke, hemorrhagic stroke, or traumatic brain injury

A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer

Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1/CD157): implications for immune/inflammatory dysfunction in neuropsychiatric disorders

Environmental stress and nanoplastics’ effects on Ciona robusta: regulation of immune/stress-related genes and induction of innate memory in pharynx and gut

Cost-effectiveness analysis of toripalimab plus chemotherapy versus chemotherapy alone for advanced non-small cell lung cancer in China

Group 1 and group 2 hemagglutinin stalk antibody response according to age

HLA allele and haplotype frequencies of registered stem cell donors in Chile

Self-assembled albumin nanoparticles induce pyroptosis for photodynamic/photothermal/immuno synergistic therapies in triple-negative breast cancer

Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

HDAC inhibitors enhance the anti-tumor effect of immunotherapies in hepatocellular carcinoma

Editorial: Host-pathogen interactions in nontuberculous mycobacterial infections

The macrophage infectivity potentiator of Trypanosoma cruzi induces innate IFN-γ and TNF-α production by human neonatal and adult blood cells through TLR2/1 and TLR4

Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination

Sex and gender influence on immunity and autoimmunity

Tocilizumab versus anakinra in COVID-19: results from propensity score matching

Variable resistance to zinc intoxication among Streptococcus agalactiae reveals a novel IS1381 insertion element within the zinc efflux transporter gene czcD

Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy

Immune response plays a role in Mycoplasma pneumoniae pneumonia

Systematic analysis between inflammation-related index and sex hormones in American adults: cross-sectional research based NHANES 2013-2016

Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice

Helicobacter pylori infection may influence prevalence and disease course in myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD) similar to MS but not AQP4-IgG associated NMOSD

The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy

Facilitating systems-level analyses of all-cause and Covid-mediated sepsis through SeptiSearch, a manually-curated compendium of dysregulated gene sets

Reactive oxygen species formation and its effect on CD4+ T cell-mediated inflammation

Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio)

Immune-related adverse events of immune checkpoint inhibitors: a review

Editorial: Insights in microbial immunology: 2022

Investigating the tumor-immune microenvironment through extracellular vesicles from frozen patient biopsies and 3D cultures

Circulating levels of cytokines and risk of cardiovascular disease: a Mendelian randomization study

Feeding the gut microbiome: impact on multiple sclerosis

Early feeding leads to molecular maturation of the gut mucosal immune system in suckling piglets

Controlled human infection models in COVID-19 and tuberculosis: current progress and future challenges

Editorial: Community series in translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma, volume II

Cytokine release syndrome and cancer immunotherapies – historical challenges and promising futures

The effectiveness of calcium electroporation combined with gene electrotransfer of a plasmid encoding IL-12 is tumor type-dependent

The overexpression of actin related protein 2/3 complex subunit 1B(ARPC1B) promotes the ovarian cancer progression via activation of the Wnt/β-catenin signaling pathway

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma

Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity

Tuberculosis infection following immune checkpoint inhibitor treatment for advanced cancer: a case report and literature review

Comparation of time-course, dose-effect, influencing factors and adverse events of biologics in the treatment of adults with moderate to severe plaque psoriasis

Genetic bases of C7 deficiency: systematic review and report of a novel deletion determining functional hemizygosity

Prediction of mortality in pneumonia patients with connective tissue disease treated with glucocorticoids or/and immunosuppressants by machine learning

Defining the pediatric response to SARS-CoV-2 variants

Clinical experience and safety of Janus kinase inhibitors in giant cell arteritis: a retrospective case series from Sweden

Bulk and single-cell RNA-sequencing analyses along with abundant machine learning methods identify a novel monocyte signature in SKCM

Engineering tandem CD33xCD146 CAR CIK (cytokine-induced killer) cells to target the acute myeloid leukemia niche

Functional CVIDs phenotype clusters identified by the integration of immune parameters after BNT162b2 boosters

Cell-based and cell-free immunotherapies for glioblastoma: current status and future directions

Harnessing type I interferon-mediated immunity to target malignant brain tumors

Sex-dependent differences in behavioral and immunological responses to antibiotic and bacteriophage administration in mice

What makes TMB an ambivalent biomarker for immunotherapy? A subtle mismatch between the sample-based design of variant callers and real clinical cohort

Case Report: Paroxysmal weakness of unilateral limb as an initial symptom in anti-LGI1 encephalitis: a report of five cases

Low-dose radiation therapy suppresses viral pneumonia by enhancing broad-spectrum anti-inflammatory responses via transforming growth factor-β production

Prognostic immunogenic characteristics of iron pendant disease modifiers in colon cancer

Anti-staphylococcus aureus adaptive immunity is impaired in end-stage renal disease patients on hemodialysis: one-year longitudinal study

On-treatment lung immune prognostic index is predictive for first-line PD-1 inhibitor combined with chemotherapy in patients with non-small cell lung cancer

Short chain fatty acids prime colorectal cancer cells to activate antitumor immunity

Bidirectional two-sample Mendelian randomization analysis reveals a causal effect of interleukin-18 levels on postherpetic neuralgia risk

Reducedhumoral response against variants of concern in childhood solid cancer patients compared to adult patients and healthy children after SARS-CoV-2 vaccination

Effect and mechanism of chlorogenic acid on cognitive dysfunction in mice by lipopolysaccharide-induced neuroinflammation

Tumor-neutrophil crosstalk promotes in vitro and in vivo glioblastoma progression

Editorial: Host immune response and regulation to parasitic infections: therapeutic approaches and defence strategies

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Efficacy and safety of chimeric antigen receptor T cell therapy in relapsed/refractory diffuse large B-cell lymphoma with different HBV status: a retrospective study from a single center

Corrigendum: Integration: gospel for immune bioinformatician on epitope-based therapy

Case report: Bullous pemphigoid in HIV-1-positive patients: interplay or coincidence? A case series and review of the literature

Fecal microbiota transplantation confirmed that 919 Syrup reduced the ratio of erucamide to 5-AVAB in hippocampus to alleviate postpartum depression by regulating gut microbes

A case report of pulmonary hepatoid adenocarcinoma: promoting standardized diagnosis and treatment of the rare disease

Corrigendum: Definition of the immune parameters related to COVID-19 severity

Corrigendum: The impact of circadian rhythm on Bacillus Calmette-Guérin vaccination effects on SARS-CoV-2 infections

Editorial: Neonatal host immune responses to pulmonary infections

Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma

Cardiovascular toxicity profiles of immune checkpoint inhibitors with or without angiogenesis inhibitors: a real-world pharmacovigilance analysis based on the FAERS database from 2014 to 2022

“Trained Immunity” from Mycobacterium spp. exposure (BCG vaccination and environmental) may have an impact on the incidence of early childhood leukemia

IL11 activates the placental inflammasome to drive preeclampsia

SARS-CoV-2 bivalent mRNA vaccine with broad protection against variants of concern

Gut epithelial barrier dysfunction in lupus triggers a differential humoral response against gut commensals

Case Report: Persistent response to combination therapy of pemigatinib, chemotherapy, and immune checkpoint inhibitor in a patient with advanced intrahepatic cholangiocarcinoma

Editorial: Oral neutrophils - the good, the bad, and the ugly

Ovalbumin-specific CD4+ and CD8+ T cells contribute to different susceptibility for Theiler’s murine encephalomyelitis virus persistence

The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment

Regulatory role of the programmed cell death 1 signaling pathway in sepsis induced immunosuppression

Editorial: A year in review: discussions in B cell biology

Activation of cytosolic RNA sensors by endogenous ligands: roles in disease pathogenesis

Circulating sepsis-related metabolite sphinganine could protect against intestinal damage during sepsis

Alterations in macrophage polarization in the craniofacial and extracranial skeleton after zoledronate application and surgical interventions – an in vivo experiment

Editorial: Immunomodulatory factors, conversion, and postoperative adjuvant therapy for hepatobiliary tumors based on immunotherapy

Mitophagy and immune infiltration in vitiligo: evidence from bioinformatics analysis

Disturbed microbiota-metabolites-immune interaction network is associated with olfactory dysfunction in patients with chronic rhinosinusitis

Two issues should be noted when designing a clinical trial to evaluate BCG effects on COVID-19

Case Report: Favorable outcome of allogeneic hematopoietic stem cell transplantation in SARSCoV2 positive recipient, risk-benefit balance between infection and leukemia

Successful treatment of a refractory intestinal Behcet’s disease with an oncology history by Vedolizumab: a case report and literature review

Combining WGCNA and machine learning to construct basement membrane-related gene index helps to predict the prognosis and tumor microenvironment of HCC patients and verifies the carcinogenesis of key gene CTSA

Insights into anti-tumor immunity via the polyomavirus shared across human Merkel cell carcinomas

SARS-CoV-2 Omicron variants: burden of disease, impact on vaccine effectiveness and need for variant-adapted vaccines

Editorial: Community series in the mechanism of trace elements on regulating immunity in prevention and control of human and animal diseases, volume II

Risk prediction model construction for post myocardial infarction heart failure by blood immune B cells

Pneumatosis cystoides intestinalis in dermatomyositis: a case series report and literature review

SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis

Akkermansia muciniphila-Nlrp3 is involved in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice

Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review

Identification and validation of a novel cuproptosis-related stemness signature to predict prognosis and immune landscape in lung adenocarcinoma by integrating single-cell and bulk RNA-sequencing

Targeting KRASG12V mutations with HLA class II-restricted TCR for the immunotherapy in solid tumors

Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers

A systems serology approach to the investigation of infection-induced antibody responses and protection in trachoma

Elevated serum levels of human epididymis protein 4 in adult patients with proliferative lupus nephritis

Exhaustion of CD8+ central memory responder T cell differentiation provokes non-melanoma skin cancer in elderly kidney transplant recipients

Diabetic macrophage small extracellular vesicles-associated miR-503/IGF1R axis regulates endothelial cell function and affects wound healing

Lack of strong innate immune reactivity renders macrophages alone unable to control productive Varicella-Zoster Virus infection in an isogenic human iPSC-derived neuronal co-culture model

The analysis of cathepsin L that mediates cellular SARS‐CoV‐2 infection leading to COVID‐19 in head and neck squamous cell carcinoma

IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities

Targeting NETs using dual-active DNase1 variants

Editorial: NK cells in viral immunology and immunotherapy

Simultaneous co-infection with swine influenza A and porcine reproductive and respiratory syndrome viruses potentiates adaptive immune responses

Serum proteomics in giant cell arteritis in response to a three-day pulse of glucocorticoid followed by tocilizumab monotherapy (the GUSTO trial)

Comprehensive analysis of endoplasmic reticulum stress-associated genes signature of ulcerative colitis

cGAMP the travelling messenger

Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages

Genetically predicted vitamin C levels significantly affect patient survival and immunotypes in multiple cancer types

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

Editorial: ILC checkpoints: expression and functions in physiological and pathological conditions

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Integrated bioinformatics identifies key mediators in cytokine storm and tissue remodeling during Vibrio mimicus infection in yellow catfish (Pelteobagrus fulvidraco)

Real-world retrospective study of immune checkpoint inhibitors in combination with radiotherapy or chemoradiotherapy as a bladder-sparing treatment strategy for muscle-invasive bladder urothelial cancer

Quantification of the zymogenicity and the substrate-induced activity enhancement of complement factor D

Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A

Cardiovascular involvement in Epstein–Barr virus infection

A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry

Intestinal colonization regulates systemic anti-commensal immune sensitivity and hyperreactivity

Editorial: Translational phenomics and its applications in immunotherapy

The role of Raptor in lymphocytes differentiation and function

Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions

Hyperprogressive disease in non-small cell lung cancer after PD-1/PD-L1 inhibitors immunotherapy: underlying killer

Differential effect of lactate on synovial fibroblast and macrophage effector functions

Corrigendum: The role of 18F−FDG PET in predicting the pathological response and prognosis to unresectable HCC patients treated with lenvatinib and PD-1 inhibitors as a conversion therapy

Single-cell RNA-seq reveals developmental deficiencies in both the placentation and the decidualization in women with late-onset preeclampsia

Uncoding the interdependency of tumor microenvironment and macrophage polarization: insights from a continuous network approach

Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies

Soluble biomarkers to predict clinical outcomes in non-small cell lung cancer treated by immune checkpoints inhibitors

Acute and chronic lung inflammation drives changes in epithelial glycans

Machine learning and integrative analysis identify the common pathogenesis of azoospermia complicated with COVID-19

Potential anti-tumor effects of Solenopsis invicta venom

Serum IL-23, IL-10, and TNF-α predict in-hospital mortality in COVID-19 patients

Elevated sHLA-G plasma levels post chemotherapy combined with ILT-2 rs10416697C allele status of the sHLA-G-related receptor predict poorest disease outcome in early triple-negative breast cancer patients

High immunogenicity of virus-like particles (VLPs) decorated with Aeromonas salmonicida VapA antigen in rainbow trout

C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation

Toll-like receptors 2, 4, and 9 modulate promoting effect of COPD-like airway inflammation on K-ras-driven lung cancer through activation of the MyD88/NF-ĸB pathway in the airway epithelium

Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response

Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation

Differential impact of environmental factors on systemic and localized autoimmunity

Regulatory mechanisms of macrophage polarization in adipose tissue

Adenoid lymphocyte heterogeneity in pediatric adenoid hypertrophy and obstructive sleep apnea

Socs3 expression in myeloid cells modulates the pathogenesis of dextran sulfate sodium (DSS)-induced colitis

Basement membrane product, endostatin, as a link between inflammation, coagulation and vascular permeability in COVID-19 and non-COVID-19 acute respiratory distress syndrome

Editorial: The immunobiology of the skin in response to the environment

Unveiling the interplay between mutational signatures and tumor microenvironment: a pan-cancer analysis

CD44 targeted delivery of oncolytic Newcastle disease virus encapsulated in thiolated chitosan for sustained release in cervical cancer: a targeted immunotherapy approach

PD-1 inhibitors-based second-line therapy for metastatic gastric cancer

Bladder cancer patients have increased NETosis and impaired DNaseI-mediated NET degradation that can be therapeutically restored in vitro

Dietary disodium fumarate supplementation alleviates subacute ruminal acidosis (SARA)-induced liver damage by inhibiting pyroptosis via mitophagy-NLRP3 inflammasome pathway in lactating Hu sheep

The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita

A tetravalent nanoparticle vaccine elicits a balanced and potent immune response against dengue viruses without inducing antibody-dependent enhancement

Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia

Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis

Enhancing immune protection against MERS-CoV: the synergistic effect of proteolytic cleavage sites and the fusion peptide and RBD domain targeting VLP immunization

The effect of inheritance of IgE responsiveness on the susceptibility of mice to Trichinella spiralis infection

Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model

Corrigendum: Crosstalk between cGAS-STING pathway and autophagy in cancer immunity

Chronic ethanol exposure impairs alveolar leukocyte infiltration during pneumococcal pneumonia, leading to an increased bacterial burden despite increased CXCL1 and nitric oxide levels

Immunometabolic reprogramming, another cancer hallmark

High-throughput sequencing technology facilitates the discovery of novel biomarkers for antiphospholipid syndrome

An optimized thermodynamics integration protocol for identifying beneficial mutations in antibody design

M-MDSC in vitro generation from mouse bone marrow with IL-3 reveals high expression and functional activity of arginase 1

Challenges and opportunities in vascularized composite allotransplantation of joints: a systematic literature review

E. coli Nissle 1917 ameliorates mitochondrial injury of granulosa cells in polycystic ovary syndrome through promoting gut immune factor IL-22 via gut microbiota and microbial metabolism

Identification and characterization of the ferroptosis-related ceRNA network in irreversible pulpitis

A single-cell RNA sequencing atlas of circulating leukocytes from healthy and osteosarcoma affected dogs

Deciphering the single-cell transcriptome network in keloids with intra-lesional injection of triamcinolone acetonide combined with 5-fluorouracil

The circadian rhythm key gene ARNTL2: a novel prognostic biomarker for immunosuppressive tumor microenvironment identification and immunotherapy outcome prediction in human cancers

PD-1/PD-L1 axis in organ fibrosis

Transcriptome-wide identification of altered RNA m6A profiles in cardiac tissue of rats with LPS-induced myocardial injury

Overcoming the immune suppressive nature of glioblastoma by leveraging the surgical intervention - current status and future perspectives

Performance of spectral flow cytometry and mass cytometry for the study of innate myeloid cell populations

The role of regulatory T cells and follicular T helper cells in HBV infection

Machine learning-based prognostic modeling of lysosome-related genes for predicting prognosis and immune status of patients with hepatocellular carcinoma

SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages

The human Stat1 gain-of-function T385M mutation causes expansion of activated T-follicular helper/T-helper 1-like CD4 T cells and sex-biased autoimmunity in specific pathogen-free mice

Potential of algae-derived alginate oligosaccharides and β-glucan to counter inflammation in adult zebrafish intestine

An update on the biologics for the treatment of antiphospholipid syndrome

Delayed and limited administration of the JAKinib tofacitinib mitigates chronic DSS-induced colitis

Interleukin-10-alveolar macrophage cell membrane-coated nanoparticles alleviate airway inflammation and regulate Th17/regulatory T cell balance in a mouse model

Spatial distribution of tumor-infiltrating T cells indicated immune response status under chemoradiotherapy plus PD-1 blockade in esophageal cancer

Editorial: The mechanism of immune cells in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC)

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand

Effects of multiple pro-inflammatory stimuli in utero on the ileum of extremely premature ovine fetuses

Fecal microbiota transplantation for irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials

Current insights into the hepatic microenvironment and advances in immunotherapy for hepatocellular carcinoma

The discrete roles of individual FOXO transcription factor family members in B-cell malignancies

Editorial: The immune system and inflammation in musculoskeletal health, aging, and disease

Genetically confirmed chronic granulomatous disease in a Kenyan child: case report

Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors

Sjögren’s syndrome: novel insights from proteomics and miRNA expression analysis

A novel antimicrobial peptide screened by a Bacillus subtilis expression system, derived from Larimichthys crocea Ferritin H, exerting bactericidal and parasiticidal activities

Impact of peptide:HLA complex stability for the identification of SARS-CoV-2-specific CD8+T cells

New progresses on cell surface protein HSPA5/BiP/GRP78 in cancers and COVID-19

The genetically predicted causal relationship of inflammatory bowel disease with bone mineral density and osteoporosis: evidence from two-sample Mendelian randomization

Machine learning-based solution reveals cuproptosis features in inflammatory bowel disease

Clinical value of anoikis-related genes and molecular subtypes identification in bladder urothelial carcinoma and in vitro validation

Nitric oxide-mediated the therapeutic properties of induced pluripotent stem cell for paraquat-induced acute lung injury

Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy

Prognostic value of human leukocyte antigen G expression in solid tumors: a systematic review and meta-analysis

Comprehensive analysis of 33 human cancers reveals clinical implications and immunotherapeutic value of the solute carrier family 35 member A2

The increased cfRNA of TNFSF4 in peripheral blood at late gestation and preterm labor: its implication as a noninvasive biomarker for premature delivery

No genetic causal association between systemic lupus erythematosus and COVID-19

Inflammatory microRNAs in cardiovascular pathology: another brick in the wall

Pan-cancer analysis identifies the correlations of Thymosin Beta 10 with predicting prognosis and immunotherapy response

Heart failure–related genes associated with oxidative stress and the immune landscape in lung cancer

The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy

Mechanism of mesenchymal stem cells and exosomes in the treatment of age-related diseases

Mycobacterial-specific secretion of cytokines and chemokines in healthcare workers with apparent resistance to infection with Mycobacterium tuberculosis

Therapeutic strategies to enhance immune response induced by multiple myeloma cells

Lytic granule exocytosis at immune synapses: lessons from neuronal synapses

Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization

High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities

The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver

Natural killer cells- from innate cells to the discovery of adaptability

Flagellar-based motility accelerates IgA-mediated agglutination of Salmonella Typhimurium at high bacterial cell densities

Production of monoclonal antibody of heat-labile toxin A subunit to identify enterotoxigenic Escherichia coli by epitope mapping using synthetic peptides

Brentuximab vedotin use in pediatric anaplastic large cell lymphoma

Single cell transcriptomics of bone marrow derived macrophages reveals Ccl5 as a biomarker of direct IFNAR-independent responses to DNA sensing

The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer

Commentary: Hepatitis B virus infection: an insight into the clinical connection and molecular interaction between hepatitis B virus and host extrahepatic cancer risk

Bioinformatics and Raman spectroscopy-based identification of key pathways and genes enabling differentiation between acute myeloid leukemia and T cell acute lymphoblastic leukemia

Analysis and comparison of SARS-CoV-2 variant antibodies and neutralizing activity for 6 months after a booster mRNA vaccine in a healthcare worker population

Editorial: Molecular mechanisms regulating phenotypic heterogeneity in human inflammatory diseases

Editorial: Intracellular trafficking in lymphocytes: the role of inner crowds in determining cell fate

Identification and immunological characterization of cuproptosis-related molecular clusters in idiopathic pulmonary fibrosis disease

Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent

An easy-to-use AIHF-nomogram to predict advanced liver fibrosis in patients with autoimmune hepatitis

Obesity contributes to hepatocellular carcinoma development via immunosuppressive microenvironment remodeling

Management of eosinophil-associated inflammatory diseases: the importance of a multidisciplinary approach

Role of endoplasmic reticulum autophagy in acute lung injury

Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?

The mechanism of ferroptosis in early brain injury after subarachnoid hemorrhage

Gasdermins assemble; recent developments in bacteriology and pharmacology

Editorial: Innate immunity and renal transplantation

Soluble monomeric human programmed cell death-ligand 1 inhibits the functions of activated T cells

Editorial: Lymphocyte functional crosstalk and regulation, volume II

Effects of tributyrin and alanyl-glutamine dipeptide on intestinal health of largemouth bass (Micropterus salmoides) fed with high soybean meal diet

DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling

Cellular activation pathways and interaction networks in vascularized composite allotransplantation

The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review

Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis

Diagnostic model constructed by five EMT-related genes for renal fibrosis and reflecting the condition of immune-related cells

Antibody response and safety of inactivated SARS-CoV-2 vaccines in chronic hepatitis B patients with and without cirrhosis

Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures

Clinical and immune-related factors associated with exacerbation in adults with well-controlled generalized myasthenia gravis

Efficacy of ICI-based treatment in advanced NSCLC patients with PD-L1≥50% who developed EGFR-TKI resistance

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

Role of the cGAS/STING pathway in the control of Brucella abortus infection acquired through the respiratory route

Mannose-binding lectin suppresses macrophage proliferation through TGF-β1 signaling pathway in Nile tilapia

Volume imaging to interrogate cancer cell-tumor microenvironment interactions in space and time

The role of mesenchymal stem cell-derived exosome in epigenetic modifications in inflammatory diseases

Macrophages induce gingival destruction via Piezo1-mediated MMPs-degrading collagens in periodontitis

Mitophagy in atherosclerosis: from mechanism to therapy

Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model

Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells

Bioinformatics and system biology approach to identify the influences among COVID-19, ARDS and sepsis

Itaconate family-based host-directed therapeutics for infections

Recent advances in ZBP1-derived PANoptosis against viral infections

Dendritic cell activation and cytokine response in vaccine breakthrough TBE patients after in vitro stimulation with TBEV

Aerosol vaccination of chicken pullets with irradiated avian pathogenic Escherichia coli induces a local immunostimulatory effect

The role of PD-1 signaling in health and immune-related diseases

Noninvasive mechanical destruction of liver tissue and tissue decellularisation by pressure-modulated shockwave histotripsy

Central nervous system demyelinating diseases: glial cells at the hub of pathology

Gut microbiome homeostasis and the future of probiotics in cancer immunotherapy

Prognostic impact of the post-treatment T cell composition and spatial organization in soft tissue sarcoma patients treated with neoadjuvant hyperthermic radio(chemo)therapy

TMIGD2 as a potential therapeutic target in glioma patients

Cholangiokines: undervalued modulators in the hepatic microenvironment

Butyrate inhibits Staphylococcus aureus-aggravated dermal IL-33 expression and skin inflammation through histone deacetylase inhibition

Efficacy of radiotherapy in combination with first-line immunotherapy and chemotherapy for advanced lung squamous cell carcinoma: a propensity score analysis

Control of enhancer and promoter activation in the type I interferon response by the histone demethylase Kdm4d/JMJD2d

Efficient complement-mediated clearance of immunosuppressed T cells by macrophages

The impact of microbially modified metabolites associated with obesity and bariatric surgery on antitumor immunity

Editorial: Nanobody-based cancer immunotherapy and immunoimaging

Atazanavir-induced unconjugated hyperbilirubinemia prevents vascular hyporeactivity during experimental human endotoxemia

Shared diagnostic genes and potential mechanism between PCOS and recurrent implantation failure revealed by integrated transcriptomic analysis and machine learning

Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity

Cytokine/chemokine profiles in people with recent infection by Mycobacterium tuberculosis

New molecular targets in Hodgkin and Reed-Sternberg cells

Mast cell marker gene signature: prognosis and immunotherapy response prediction in lung adenocarcinoma through integrated scRNA-seq and bulk RNA-seq

From bench to bedside: the history and progress of CAR T cell therapy

Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases

Latroeggtoxin-VI protects nerve cells and prevents depression by inhibiting NF-κB signaling pathway activation and excessive inflammation

Ras family signaling pathway in immunopathogenesis of inflammatory rheumatic diseases

Adverse events with risankizumab in the real world: postmarketing pharmacovigilance assessment of the FDA adverse event reporting system

Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36

Prediction of risk and overall survival of pancreatic cancer from blood soluble immune checkpoint-related proteins

Omicron (B.1.1.529) BA.1 or BA.2-related effects on immune responses in previously naïve versus imprinted individuals: immune imprinting as an advantage in the humoral immune response against novel variants

Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity

Conversion of primary liver cancer after targeted therapy for liver cancer combined with AFP-targeted CAR T-cell therapy: a case report

Cx3cr1 controls kidney resident macrophage heterogeneity

Arterial wall fibrosis in Takayasu arteritis and its potential for therapeutic modulation

Monitoring of strength, inflammation and muscle function in allogenic stem-cell transplantation patients – a pilot study for novel biomarker and risk stratification determination

Editorial: Controversies and expectations for prevention and treatment of graft-versus-host-disease: a biological and clinical perspective

Human cytomegalovirus and Epstein–Barr virus infections occurring early after transplantation are risk factors for antibody-mediated rejection in heart transplant recipients

The importance of biomarker development for monitoring type 1 diabetes progression rate and therapeutic responsiveness

Serum immune mediators as novel predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients with high tissue-PD-L1 expression

Indeterminate results of interferon gamma release assays in the screening of latent tuberculosis infection: a systematic review and meta-analysis

B cell activation via immunometabolism in systemic lupus erythematosus

Chicken adaptive response to nutrient density: immune function change revealed by transcriptomic analysis of spleen

Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables

Single-cell sequencing technology in colorectal cancer: a new technology to disclose the tumor heterogeneity and target precise treatment

ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response

Monoclonal antibodies for prophylaxis and therapy of respiratory syncytial virus, SARS-CoV-2, human immunodeficiency virus, rabies and bacterial infections: an update from the World Association of Infectious Diseases and Immunological Disorders and the Italian Society of Antinfective Therapy

Broad-spectrum anti-HIV activity and high drug resistance barrier of lipopeptide HIV fusion inhibitor LP-19

Dietary yeast glycoprotein supplementation improves the growth performance, intestinal health and disease resistance of largemouth bass (Micropterus salmoides) fed low-fishmeal diets

Adenoviral-vectored epigraph vaccine elicits robust, durable, and protective immunity against H3 influenza A virus in swine

Regulatory roles of SP-A and exosomes in pneumonia-induced acute lung and kidney injuries

Case Report: Optic neuritis as the initial presentation of Orientia tsutsugamushi infection detected by metagenomic next-generation sequencing

Evaluation of neoadjuvant immunotherapy and traditional neoadjuvant therapy for resectable esophageal cancer: a systematic review and single-arm and network meta-analysis

Increase in gut permeability and oxidized ldl is associated with post-acute sequelae of SARS-CoV-2

Dynamic polarization of tumor-associated macrophages and their interaction with intratumoral T cells in an inflamed tumor microenvironment: from mechanistic insights to therapeutic opportunities

Combined analysis of single-cell and bulk RNA sequencing reveals the expression patterns of circadian rhythm disruption in the immune microenvironment of Alzheimer’s disease

Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides

The internal dose makes the poison: higher internalization of polystyrene particles induce increased perturbation of macrophages

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

Human papillomavirus vaccination in low- and middle-income countries: progression, barriers, and future prospective

Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology

Update on transfusion-related acute lung injury: an overview of its pathogenesis and management

The manipulation of cell suspensions from zebrafish intestinal mucosa contributes to understanding enteritis

A novel precision-serology assay for SARS-CoV-2 infection based on linear B-cell epitopes of Spike protein

Potential angiogenic, immunomodulatory, and antifibrotic effects of mesenchymal stem cell-derived extracellular vesicles in systemic sclerosis

Proteomic profiling of single extracellular vesicles reveals colocalization of SARS-CoV-2 with a CD81/integrin-rich EV subpopulation in sputum from COVID-19 severe patients

Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection

Identification of the shared gene signatures and molecular mechanisms between multiple sclerosis and non-small cell lung cancer

Enhancing the therapeutic activity of hyperimmune IgG against chikungunya virus using FcγRIIIa affinity chromatography

Understanding preclinical and clinical immunogenicity risks in novel biotherapeutics development

Heterologous vaccination with inactivated vaccine and mRNA vaccine augments antibodies against both spike and nucleocapsid proteins of SARS-CoV-2: a local study in Macao

Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue

Vaccine development for mosquito-borne viral diseases

C-reactive protein as the biomarker of choice to monitor the effects of exercise on inflammation in Parkinson’s disease

Molecular treatment trajectories within psoriatic T lymphocytes: a mini review

Anti-tumor efficacy of anti-GD2 CAR NK-92 cells in diffuse intrinsic pontine gliomas

Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing

Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming

Modulation of innate immunity in airway epithelium for host-directed therapy

An estrogen response-related signature predicts response to immunotherapy in melanoma

Interferon regulatory factor 7 in inflammation, cancer and infection

Editorial: 21st century advances in type 1 diabetes research and immunotherapy

The role of dendritic cells and their immunometabolism in rheumatoid arthritis

Biomarkers detected in cord blood predict vaccine responses in young infants

Editorial: Novel perspectives on the NLRP3 inflammasome

Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells

Peripheral nerve repair is associated with augmented cross-tissue inflammation following vascularized composite allotransplantation

CD16+ monocytes are involved in the hyper-inflammatory state of Prader-Willi Syndrome by single-cell transcriptomic analysis

Perspective: Daniela Novick, cytokines and their receptors

Editorial: Novel biomarkers for predicting response to cancer immunotherapy

Adaptive immunology of Cryptococcus neoformans infections—an update

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers

Comprehensively prognostic and immunological analysis of snail family transcriptional repressor 2 in pan-cancer and identification in pancreatic carcinoma

Editorial: Transcriptional and epigenetic control of T and innate lymphoid cell development and function

Influence of bariatric surgery on the peripheral blood immune system of female patients with morbid obesity revealed by high-dimensional mass cytometry

SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy

The chemokine landscape: one system multiple shades

Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction

TLR4-mediated release of heparin-binding protein in human airways: a co-stimulatory role for IL-26

Tertiary lymphoid structures predict the prognosis and immunotherapy response of cholangiocarcinoma

Immunotherapy of hepatocellular carcinoma: recent progress and new strategy

Corrigendum: Uncovering a 500 million year old history and evidence of pseudogenization for TLR15

Crosstalk between cholesterol metabolism and psoriatic inflammation

Comprehensive analysis of FOXM1 immune infiltrates, m6a, glycolysis and ceRNA network in human hepatocellular carcinoma

Impact of SARS-CoV2 infection on anti-apolipoprotein A-1 IgG response in inflammatory rheumatic diseases

Integrated bioinformatics and machine learning algorithms reveal the critical cellular senescence-associated genes and immune infiltration in heart failure due to ischemic cardiomyopathy

Editorial: Insights in antigen presenting cell biology: 2022

TMBserval: a statistical explainable learning model reveals weighted tumor mutation burden better categorizing therapeutic benefits

CD4+ T cells are the major predictor of HCMV control in allogeneic stem cell transplant recipients on letermovir prophylaxis

CCDC134 facilitates T cell activation through the regulation of early T cell receptor signaling

Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma

MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway

Molecular mechanisms and cellular functions of liquid-liquid phase separation during antiviral immune responses

Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice

Minimal residual disease status improved the response evaluation in patients with Waldenström’s macroglobulinemia

Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling

Dual inhibition of phosphoinositide 3-kinases delta and gamma reduces chronic B cell activation and autoantibody production in a mouse model of lupus

Crosstalk between colorectal cancer cells and cancer-associated fibroblasts in the tumor microenvironment mediated by exosomal noncoding RNAs

Immunoglobulin E-virus phenotypes of infant bronchiolitis and risk of childhood asthma

Radioimmunotherapy in colorectal cancer treatment: present and future

Corrigendum: Vulnerability to meningococcal disease in immunodeficiency due to a novel pathogenic missense variant in NFKB1

Current hotspot and study trend of innate immunity in COVID-19: a bibliometric analysis from 2020 to 2022

Comparative genomics of the Leukocyte Receptor Complex in carnivores

New tools for immunologists: models of lymph node function from cells to tissues

Low-dose post-transplant cyclophosphamide with G-CSF/ATG based haploidentical protocol provides favorable outcomes for SAA patients

Characterization of RBD-specific cross-neutralizing antibodies responses against SARS-CoV-2 variants from COVID-19 convalescents

Type 1 interferon signature in peripheral blood mononuclear cells and monocytes of idiopathic inflammatory myopathy patients with different myositis-specific autoantibodies

NK cell defects: implication in acute myeloid leukemia

Association between inflammatory bowel disease and interleukins, chemokines: a two-sample bidirectional mendelian randomization study

Identification and experimental validation of mitochondria-related genes biomarkers associated with immune infiltration for sepsis

Editorial: Non-coding RNA in improving the efficacy of cancer immunotherapy

Uncovering new insights into the role of the ubiquitin ligase Smurf1 on the regulation of innate immune signaling and resistance to infection

Biological activity of human IgE monoclonal antibodies targeting Der p 2, Fel d 1, Ara h 2 in basophil mediator release assays

Exploiting endocytosis for transfection of mRNA for cytoplasmatic delivery using cationic gold nanoparticles

Early activation and recruitment of invariant natural killer T cells during liver ischemia-reperfusion: the major role of the alarmin interleukin-33

Intermittent fasting protects against food allergy in a murine model via regulating gut microbiota

Pembrolizumab-induced optic neuropathy – a case report

T cell immunity following COVID-19 vaccination in adult patients with primary antibody deficiency – a 22-month follow-up

Development and validation of urinary exosomal microRNA biomarkers for the diagnosis of acute rejection in kidney transplant recipients

Unveiling a Virulence-Regulating Mechanism in Aeromonas hydrophila: a Quantitative Exoproteomic Analysis of an AraC-Like Protein

Integration analysis of tumor metagenome and peripheral immunity data of diffuse large-B cell lymphoma

Whole intestinal microbiota transplantation is more effective than fecal microbiota transplantation in reducing the susceptibility of DSS-induced germ-free mice colitis

A rapid and efficient platform for antiviral crRNA screening using CRISPR-Cas13a-based nucleic acid detection

Differences in the phenotypes and transcriptomic signatures of chimeric antigen receptor T lymphocytes manufactured via electroporation or lentiviral transfection

Immunity and reproduction protective effects of Chitosan Oligosaccharides in Cyclophosphamide/Busulfan-induced premature ovarian failure model mice

Preclinical models and evaluation criteria of prostatitis

Metabolic changes in kidney stone disease

Editorial: Inborn errors of immunity and mucosal immunity

Human IL-32θA94V mutant attenuates monocyte-endothelial adhesion by suppressing the expression of ICAM-1 and VCAM-1 via binding to cell surface receptor integrin αVβ3 and αVβ6 in TNF-α-stimulated HUVECs

African swine fever virus QP383R dampens type I interferon production by promoting cGAS palmitoylation

CD24-Siglec interactions in inflammatory diseases

Ulcerative colitis complicated by primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome: a case report and literature review

Case Report: The application of associating liver partition and portal vein ligation for staged hepatectomy in patients with hepatitis b virus-related hepatocellular carcinoma after undergoing treatment with an immune checkpoint inhibitor: a report of two cases

Single-cell landscape dissecting the transcription and heterogeneity of innate lymphoid cells in ischemic heart

Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2

Maintained imbalance of triglycerides, apolipoproteins, energy metabolites and cytokines in long-term COVID-19 syndrome patients

TME-targeted approaches of brain metastases and its clinical therapeutic evidence

Innate and adaptive immunity to SARS-CoV-2 and predisposing factors

Higher radiation dose on immune cells is associated with radiation-induced lymphopenia and worse prognosis in patients with locally advanced esophageal squamous cell carcinoma

Gut microbial profile of treatment-naive patients with primary biliary cholangitis

An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa

Integrative single-cell RNA and ATAC sequencing reveals that the FOXO1-PRDX2-TNF axis regulates tendinopathy

Evaluating the comorbidities of age and cigarette smoking on stroke outcomes in the context of anti-complement mitigation strategies

Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study

Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review

Grouper RIP2 inhibits Singapore grouper iridovirus infection by modulating ASC-caspase-1 interaction

Case Report: Ofatumumab treatment in a patient with rituximab-intolerant refractory autoimmune GFAP astrocytopathy

Cause or consequence? The role of IL-1 family cytokines and receptors in neuroinflammatory and neurodegenerative diseases

A systemically administered detoxified TLR4 agonist displays potent antitumor activity and an acceptable tolerance profile in preclinical models

Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil

Axl promotes intracranial aneurysm rupture by regulating macrophage polarization toward M1 via STAT1/HIF-1α

Inflammatory abrasion of hematopoietic stem cells: a candidate clue for the post-CAR-T hematotoxicity?

Global transmission of monkeypox virus—a potential threat under the COVID-19 pandemic

Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension

GNPNAT1 is a potential biomarker correlated with immune infiltration and immunotherapy outcome in breast cancer

Prognostic immune markers identifying patients with severe COVID-19 who respond to tocilizumab

The efficacy of adebrelimab compared with durvalumab and atezolizumab in untreated extensive-stage small-cell lung cancer: a survival analysis of reconstructed patient-level data

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

Automated clustering reveals CD4+ T cell subset imbalances in rheumatoid arthritis

Determinants of tumor immune evasion: the role of T cell exposed motif frequency and mutant amino acid exposure

SIRT2 plays complex roles in neuroinflammation neuroimmunology-associated disorders

Cell-penetrating TLR inhibitor peptide alleviates ulcerative colitis by the functional modulation of macrophages

The molecular mechanism of Gorham syndrome: an update

Natural products in attenuating renal inflammation via inhibiting the NLRP3 inflammasome in diabetic kidney disease

Omicron infection-associated T- and B-cell immunity in antigen-naive and triple-COVID-19-vaccinated individuals

Epigenetically altered macrophages promote development of diabetes-associated atherosclerosis

Plasma lipidomics of primary biliary cholangitis and its comparison with Sjögren’s syndrome

TANK shapes an immunosuppressive microenvironment and predicts prognosis and therapeutic response in glioma

Dysregulation of immune response in PCOS organ system

Regulation of short-chain fatty acids in the immune system

Presence of immune factors in freshwater mussel (Hyriopsis cumingii) entails autologous serum an essential component in the culture of mantle cells

A linear B-cell epitope close to the furin cleavage site within the S1 domain of SARS-CoV-2 Spike protein discriminates the humoral immune response of nucleic acid- and protein-based vaccine cohorts

Epigenetic dysregulation of autophagy in sepsis-induced acute kidney injury: the underlying mechanisms for renoprotection

Chromosomal microarray analysis supplements exome sequencing to diagnose children with suspected inborn errors of immunity

Editorial: Expert opinions and perspectives in immunity to worms infection: 2022

Neurotransmitters: promising immune modulators in the tumor microenvironment

The role of circadian clock-controlled mitochondrial dynamics in diabetic cardiomyopathy

The shed P2X7 receptor is an index of adverse clinical outcome in COVID-19 patients

Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses

Identification of hub cuproptosis related genes and immune cell infiltration characteristics in periodontitis

A novel immunogenic cell death–related subtype classification and risk signature for predicting prognosis and immunotherapy efficacy in gastric cancer

Heme oxygenase-1 determines the cell fate of ferroptotic death of alveolar macrophages in COPD

Machine learning-based glycolysis-associated molecular classification reveals differences in prognosis, TME, and immunotherapy for colorectal cancer patients

Targeted CD7 CAR T-cells for treatment of T-Lymphocyte leukemia and lymphoma and acute myeloid leukemia: recent advances

The role of 18F−FDG PET in predicting the pathological response and prognosis to unresectable HCC patients treated with lenvatinib and PD-1 inhibitors as a conversion therapy

Is TNF alpha a mediator in the co-existence of malaria and type 2 diabetes in a malaria endemic population?

Editorial: Non-reactogenic vaccines against Q-fever

Trans-population graph-based coverage optimization of allogeneic cellular therapy

Understanding humoral immunity and multiple sclerosis severity in Black, and Latinx patients

Establishment of a novel lysosomal signature for the diagnosis of gastric cancer with in-vitro and in-situ validation

Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB

Benzo[a]pyrene induces NLRP1 expression and promotes prolonged inflammasome signaling

Incidence, clinical characteristics and prognosis of tumor lysis syndrome following B-cell maturation antigen-targeted chimeric antigen receptor-T cell therapy in relapsed/refractory multiple myeloma

The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages

Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice

TCR T cells overexpressing c-Jun have better functionality with improved tumor infiltration and persistence in hepatocellular carcinoma

Activated P2X receptors can up-regulate the expressions of inflammation-related genes via NF-κB pathway in spotted sea bass (Lateolabrax maculatus)

Safety and efficacy of tislelizumab plus chemotherapy versus chemotherapy alone as neoadjuvant treatment for patients with locally advanced gastric cancer: real-world experience with a consecutive patient cohort

Detection of specific RBD+ IgG+ memory B cells by flow cytometry in healthcare workers and patients with inborn errors of immunity after BNT162b2 m RNA COVID-19 vaccination

Evaluation of triple negative breast cancer with heterogeneous immune infiltration

Single-cell detection of primary transcripts, their genomic loci and nuclear factors by 3D immuno-RNA/DNA FISH in T cells

Cost-effectiveness analysis of serplulimab plus chemotherapy in the first-line treatment for PD-L1-positive esophageal squamous cell carcinoma in China

Patient-derived models facilitate precision medicine in liver cancer by remodeling cell-matrix interaction

Gut microbiota in perioperative neurocognitive disorders: current evidence and future directions

Sex-biased immunological processes drive hidradenitis suppurativa

Characterization of antigen-specific CD8+ memory T cell subsets in peripheral blood of patients with multiple sclerosis

Editorial: Decoding immunologic complex systems in cancer: the cutting-edge technologies revolutionizing cancer immunology and immunotherapy

Corrigendum: Can vitamin D status influence seroconversion to SARS-COV2 vaccines?

Circulating extracellular particles from severe COVID-19 patients show altered profiling and innate lymphoid cell-modulating ability

Effects of HLA single chain trimer design on peptide presentation and stability

Corrigendum: Different recovery patterns of CMV-specific and WT1-specific T cells in patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: impact of CMV infection and leukemia relapse

Tubeimuside I improves the efficacy of a therapeutic Fusobacterium nucleatum dendritic cell-based vaccine against colorectal cancer

The cuproptosis-associated 11 gene signature as a predictor for outcomes and response to Bacillus Calmette-Guerin and immune checkpoint inhibitor therapies in bladder carcinoma

Myo1f has an essential role in γδT intraepithelial lymphocyte adhesion and migration

Analysis of immunogenic cell death in ascending thoracic aortic aneurysms based on single-cell sequencing data

Efficient ex vivo expansion of conserved element vaccine-specific CD8+ T-cells from SHIV-infected, ART-suppressed nonhuman primates

Algorithm to improve the diagnosis of paraneoplastic neurological syndromes associated with SOX1 antibodies

How Toll-like receptors influence Parkinson’s disease in the microbiome–gut–brain axis

HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells

Elevated MPP6 expression correlates with an unfavorable prognosis, angiogenesis and immune evasion in hepatocellular carcinoma

Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis

The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion

Multi-omics analysis of Siglec family genes in cutaneous melanoma

Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

Reduced immunogenicity of a live Salmonella enterica serovar Typhimurium vaccine in aged mice

Cytokines induced memory-like NK cells engineered to express CD19 CAR exhibit enhanced responses against B cell malignancies

Macrophage polarization states in atherosclerosis

Relationship between histone demethylase LSD family and development and prognosis of gastric cancer

Integrating machine learning and single-cell trajectories to analyze T-cell exhaustion to predict prognosis and immunotherapy in colon cancer patients

Analysis of T-cell alloantigen response via a direct pathway in kidney transplant recipients with donor-specific antibodies

Case Report: Interindividual variability and possible role of heterozygous variants in a family with deficiency of adenosine deaminase 2: are all heterozygous born equals?

Editorial: Host-virus interaction at the omics and ecology levels

Risk factors and characteristics influencing humoral response to COVID-19 vaccination in patients after allogeneic stem cell transplantation

Cell membrane-bound toll-like receptor-1/2/4/6 monomers and -2 heterodimer inhibit enterovirus 71 replication by activating the antiviral innate response

Editorial: Rising stars in inflammation 2021

Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear

Edwardsiella piscicida infection reshapes the intestinal microbiome and metabolome of big-belly seahorses: mechanistic insights of synergistic actions of virulence factors

Knowledge mapping of immune thrombocytopenia: a bibliometric study

Expression of Cartilage Oligomeric Matrix Protein in colorectal cancer is an adverse prognostic factor and correlates negatively with infiltrating immune cells and PD-L1 expression

Turicibacter and Acidaminococcus predict immune-related adverse events and efficacy of immune checkpoint inhibitor

Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling

Revisiting Aire and tissue-restricted antigens at single-cell resolution

Naproxen chemoprevention induces proliferation of cytotoxic lymphocytes in Lynch Syndrome colorectal mucosa

Lipopolysaccharide-induced immune stress negatively regulates broiler chicken growth via the COX-2-PGE2-EP4 signaling pathway

How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation

Leptin deficiency in CD8+ T cells ameliorates non-segmental vitiligo by reducing interferon-γ and Granzyme B

Carbon dot-based nanomaterials: a promising future nano-platform for targeting tumor-associated macrophages

A prediction model identifying glycolysis signature as therapeutic target for psoriasis

The application of autologous cancer immunotherapies in the age of memory-NK cells

MIR222HG attenuates macrophage M2 polarization and allergic inflammation in allergic rhinitis by targeting the miR146a-5p/TRAF6/NF-κB axis

Clinical benefits of PD-1 inhibitors in specific subgroups of patients with advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis of phase 3 randomized clinical trials

Stress granules: potential therapeutic targets for infectious and inflammatory diseases

The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment

Type I and III interferons shape the retinal cytokine network and barrier function in an in vitro model of ocular toxoplasmosis

Repurposing pentamidine for cancer immunotherapy by targeting the PD1/PD-L1 immune checkpoint

Corrigendum: Pre-transplant CRP–albumin ratio as a biomarker in patients receiving haploidentical allogeneic hematopoietic transplantation: developing a novel DRCI-based nomogram

Basophils beyond allergic and parasitic diseases

Editorial: Neuroimmunology in Africa

The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

Corrigendum: Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature

Clinical, imaging features and outcomes of patients with anti-GFAP antibodies: a retrospective study

Seroprevalence and durability of antibody responses to AstraZeneca vaccination in Ugandans with prior mild or asymptomatic COVID-19: implications for vaccine policy

Atractylodes macrocephala Koidz. volatile oil relieves acute ulcerative colitis via regulating gut microbiota and gut microbiota metabolism

Diffuse large B-cell lymphoma microenvironment displays a predominant macrophage infiltrate marked by a strong inflammatory signature

Advancements in CAR-NK therapy: lessons to be learned from CAR-T therapy

The potential of regulatory T cell-based therapies for alopecia areata

Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis

Prognostic value of prelymphodepletion absolute lymphocyte counts in relapsed/refractory diffuse large B-cell lymphoma patients treated with chimeric antigen receptor T cells

Innate immunity and early liver inflammation

Classification of tuberculosis-related programmed cell death-related patient subgroups and associated immune cell profiling

A self-binding immune complex vaccine elicits strong neutralizing responses against herpes simplex virus in mice

Integrative proteomic profiling of lung tissues and blood in acute respiratory distress syndrome

Editorial: Adaptive immunity in local tissues

TLR4 activation by lysozyme induces pain without inflammation

Biomarkers for immunotherapy in esophageal cancer

Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease

Changes in the molecular profiles of large-vessel vasculitis treated with biological disease-modifying anti-rheumatic drugs and Janus kinase inhibitors

A high-concentrate diet induces inflammatory injury via regulating Ca2+/CaMKKβ-mediated autophagy in mammary gland tissue of dairy cows

CTLA4 mRNA is downregulated by miR-155 in regulatory T cells, and reduced blood CTLA4 levels are associated with poor prognosis in metastatic melanoma patients

Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival

The thymus and T-cell ontogeny in ballan wrasse (Labrus bergylta) is nutritionally modelled

Quillaja brasiliensis nanoparticle adjuvant formulation improves the efficacy of an inactivated trivalent influenza vaccine in mice

Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection

Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the NK function in Hu-BLT mice

Regulatory T cells in peripheral tissue tolerance and diseases

High opsonic phagocytosis activity and growth inhibition of merozoites are associated with RON4 antibody levels and protect against febrile malaria in Ghanaian children

A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals

Identification of multiple novel susceptibility genes associated with autoimmune thyroid disease

Year: 2023 Month: April Volume: 14

Year: 2023 Month: April Volume: 13

Year: 2023 Month: March Volume: 14

Year: 2023 Month: March Volume: 13

Year: 2023 Month: February Volume: 14

Year: 2023 Month: February Volume: 13

Year: 2023 Month: January Volume: 14

Year: 2023 Month: January Volume: 13

Year: 2022 Month: December Volume: 13

Year: 2022 Month: November Volume: 13

Year: 2022 Month: October Volume: 13

Year: 2022 Month: September Volume: 13

Year: 2022 Month: August Volume: 13

Year: 2022 Month: July Volume: 13

Year: 2022 Month: June Volume: 13

Year: 2022 Month: May Volume: 13

Year: 2022 Month: April Volume: 13

Year: 2022 Month: March Volume: 13

Year: 2022 Month: March Volume: 12

Year: 2022 Month: February Volume: 13

Year: 2022 Month: February Volume: 12

Year: 2022 Month: January Volume: 13

Year: 2022 Month: January Volume: 12

Year: 2021 Month: December Volume: 12

Year: 2021 Month: November Volume: 12

Year: 2021 Month: October Volume: 12

Year: 2021 Month: September Volume: 12

Year: 2021 Month: August Volume: 12

Year: 2021 Month: July Volume: 12

Year: 2021 Month: June Volume: 12

Year: 2021 Month: May Volume: 12

Year: 2021 Month: April Volume: 12

Year: 2021 Month: March Volume: 12

Year: 2021 Month: March Volume: 11

Year: 2021 Month: February Volume: 12

Year: 2021 Month: February Volume: 11

Year: 2021 Month: January Volume: 12

Year: 2021 Month: January Volume: 11

Year: 2020 Month: December Volume: 11

Year: 2020 Month: November Volume: 11

Year: 2020 Month: October Volume: 11

Year: 2020 Month: September Volume: 11

Year: 2020 Month: August Volume: 11

Year: 2020 Month: July Volume: 11

Year: 2020 Month: June Volume: 11

Year: 2020 Month: May Volume: 11

Year: 2020 Month: April Volume: 11

Year: 2020 Month: March Volume: 11

Year: 2020 Month: February Volume: 11

Year: 2020 Month: February Volume: 10

Year: 2020 Month: January Volume: 11

Year: 2020 Month: January Volume: 10

Year: 2019 Month: December Volume: 10

Year: 2019 Month: November Volume: 10

Year: 2019 Month: October Volume: 10

Year: 2019 Month: September Volume: 10

Year: 2019 Month: August Volume: 10

Year: 2019 Month: July Volume: 10

Year: 2019 Month: June Volume: 10

Year: 2019 Month: May Volume: 10

Year: 2019 Month: April Volume: 10

Year: 2019 Month: March Volume: 10

Year: 2019 Month: February Volume: 10

Year: 2019 Month: January Volume: 10

Year: 2019 Month: February Volume: 9

Year: 2019 Month: January Volume: 9

Year: 2018 Month: December Volume: 9

Year: 2018 Month: November Volume: 9

Year: 2018 Month: October Volume: 9

Year: 2018 Month: September Volume: 9

Year: 2018 Month: August Volume: 9

Year: 2018 Month: July Volume: 9

Year: 2018 Month: June Volume: 9

Year: 2018 Month: May Volume: 9

Year: 2018 Month: April Volume: 9

Year: 2018 Month: March Volume: 9

Year: 2018 Month: February Volume: 9

Year: 2018 Month: February Volume: 8

Year: 2018 Month: January Volume: 9

Year: 2018 Month: January Volume: 8

Year: 2017 Month: December Volume: 8

Year: 2017 Month: November Volume: 8

Year: 2017 Month: October Volume: 8

Year: 2017 Month: September Volume: 8

Year: 2017 Month: August Volume: 8

Year: 2017 Month: July Volume: 8

Year: 2017 Month: June Volume: 8

Year: 2017 Month: May Volume: 8

Year: 2017 Month: April Volume: 8

Year: 2017 Month: April Volume: 7

Year: 2017 Month: March Volume: 8

Year: 2017 Month: February Volume: 8

Year: 2017 Month: January Volume: 8

Year: 2017 Month: January Volume: 7

Year: 2016 Month: December Volume: 7

Year: 2016 Month: November Volume: 7

Year: 2016 Month: November Volume: 6

Year: 2016 Month: October Volume: 7

Year: 2016 Month: September Volume: 7

Year: 2016 Month: August Volume: 7

Year: 2016 Month: July Volume: 7

Year: 2016 Month: June Volume: 7

Year: 2016 Month: May Volume: 7

Year: 2016 Month: April Volume: 7

Year: 2016 Month: March Volume: 7

Year: 2016 Month: February Volume: 7

Year: 2016 Month: January Volume: 7

Year: 2016 Month: January Volume: 6

Year: 2015 Month: December Volume: 6

Year: 2015 Month: November Volume: 6

Year: 2015 Month: October Volume: 6

Year: 2015 Month: September Volume: 6

Year: 2015 Month: August Volume: 6

Year: 2015 Month: July Volume: 6

Year: 2015 Month: June Volume: 6

Year: 2015 Month: May Volume: 6

Year: 2015 Month: April Volume: 6

Year: 2015 Month: March Volume: 6

Year: 2015 Month: February Volume: 6

Year: 2015 Month: January Volume: 6

Year: 2015 Month: January Volume: 5

Year: 2014 Month: December Volume: 5

Year: 2014 Month: November Volume: 5

Frontiers in Industrial Engineering

Frontiers in Insect Science

Frontiers in Integrative Neuroscience

Frontiers in Lab on a Chip Technologies

Frontiers in Language Sciences

Frontiers in Lupus

Frontiers in Malaria

Frontiers in Mammal Science

Frontiers in Manufacturing Technology

Frontiers in Marine Science

Frontiers in Materials

Frontiers in Mechanical Engineering

Frontiers in Medical Engineering

Frontiers in Medical Technology

Frontiers in Medicine

Frontiers in Membrane Science and Technology

Frontiers in Metals and Alloys

Frontiers in Microbiology

Frontiers in Microbiomes

Frontiers in Molecular Biosciences

Frontiers in Molecular Medicine

Frontiers in Molecular Neuroscience

Frontiers in Nanotechnology

Frontiers in Natural Products

Frontiers in Nephrology

Frontiers in Network Physiology

Frontiers in Neural Circuits

Frontiers in Neuroanatomy

Frontiers in Neuroengineering

Frontiers in Neuroergonomics

Frontiers in Neuroimaging

Frontiers in Neuroinformatics

Frontiers in Neurology

Frontiers in Neurorobotics

Frontiers in Neuroscience

Frontiers in Nuclear Engineering

Frontiers in Nuclear Medicine

Frontiers in Nutrition

Frontiers in Ocean Sustainability

Frontiers in Oncology

Frontiers in Ophthalmology

Frontiers in Oral Health

Frontiers in Pain Research

Frontiers in Parasitology

Frontiers in Pediatrics

Frontiers in Pharmacology

Frontiers in Photonics

Frontiers in Physics

Frontiers in Physiology

Frontiers in Plant Science

Frontiers in Political Science

Frontiers in Psychiatry

Frontiers in Psychology

Frontiers in Public Health

Frontiers in Quantum Science and Technology

Frontiers in RNA Research

Frontiers in Radiology

Frontiers in Rehabilitation Sciences

Frontiers in Remote Sensing

Frontiers in Reproductive Health

Frontiers in Research Metrics and Analytics

Frontiers in Robotics and AI

Frontiers in Science

Frontiers in Sensors

Frontiers in Signal Processing

Frontiers in Sleep

Frontiers in Smart Grids

Frontiers in Sociology

Frontiers in Soft Matter

Frontiers in Soil Science

Frontiers in Space Technologies

Frontiers in Sports and Active Living

Frontiers in Stroke

Frontiers in Surgery

Frontiers in Sustainability

Frontiers in Sustainable Cities

Frontiers in Sustainable Energy Policy

Frontiers in Sustainable Food Systems

Frontiers in Sustainable Resource Management

Frontiers in Sustainable Tourism

Frontiers in Synaptic Neuroscience

Frontiers in Systems Biology

Frontiers in Systems Neuroscience

Frontiers in Thermal Engineering

Frontiers in Toxicology

Frontiers in Transplantation

Frontiers in Tropical Diseases

Frontiers in Urology

Frontiers in Veterinary Science

Frontiers in Virology

Frontiers in Virtual Reality

Frontiers in Water

Frontiers in the Internet of Things

B cell activation via immunometabolism in systemic lupus erythematosus

Content Provider	frontiers
Author	Iwata, Shigeru Hajime Sumikawa, Maiko Tanaka, Yoshiya
Abstract	Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease involving multiple organs in which B cells perform important functions such as antibody and cytokine production and antigen presentation. B cells are activated and differentiated by the primary B cell receptor, co-stimulatory molecule signals—such as CD40/CD40L—, the Toll-like receptors 7,9, and various cytokine signals. The importance of immunometabolism in the activation, differentiation, and exerting functions of B cells and other immune cells has been widely reported in recent years. However, the regulatory mechanism of immunometabolism in B cells and its involvement in SLE pathogenesis remain elusive. Similarly, the importance of the PI3K-Akt-mTOR signaling pathway, glycolytic system, and oxidative phosphorylation has been demonstrated in the mechanisms of B cell immunometabolic activation, mainly in mouse studies. However, the activation of the mTOR pathway in B cells in patients with SLE, the induction of plasmablast differentiation through metabolic and transcription factor regulation by mTOR, and the involvement of this phenomenon in SLE pathogenesis are unclear. In our studies using activated B cells derived from healthy donors and from patients with SLE, we observed that methionine, an essential amino acid, is important for mTORC1 activation. Further, we observed that splenic tyrosine kinase and mTORC1 activation synergistically induce EZH2 expression and plasmablasts by suppressing BACH2 expression through epigenomic modification. Additionally, we identified another mechanism by which the glutaminolysis-induced enhancement of mitochondrial function promotes plasmablast differentiation in SLE. In this review, we focused on the SLE exacerbation mechanisms related to the activation of immune cells—especially B cells—and immunometabolism and reported the latest findings in the field.
ISSN	16643224
DOI	10.3389/fimmu.2023.1155421
Volume Number	14
Journal	Frontiers in Immunology
Language	English
Publisher Date	2023-05-15
Access Restriction	Open
Subject Keyword	B-cell Mitochondria Glutaminolysis SLE Immunometabolism
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in