Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | frontiers |
|---|---|
| Author | Lu, Peng Ding, Xiaoyan Sun, Jiansheng Wang, Rong Liu, Jiasong Liu, Qiao Zhu, Limei Lu, Wei |
| Abstract | Objective: School tuberculosis outbreaks are common in China. This study aimed to introduce and evaluate a new screening process to help control outbreaks. Methods: Screening information of students in three school tuberculosis outbreaks was collected. QuantiFERON-TB gold in-tube (QFT) results were used as the conference standard to determine the cut-off value of tuberculin skin test (TST) for diagnosing students who needed to have preventive medication. Results: A total of 1,232 students and teachers coming from three different schools which all had more than three student tuberculosis patients were included in this study. In total, 308 (25.0%) students had an induration diameter ≥10mm; among students in a different class with the index case the infection rate was 24.4% (264/1084), which was lower than it among students in a same class (29.7%)(P=0.157); Students in the same class as the index tuberculosis case had a much higher QFT positivity compared to those in a different class (58.1% versus 7.7%, P<0.0001). Diagnostic agreement between TST≥10mm and QFT was 36.6%. The diagnostic value reached highest when the induration diameter of the TST was 9mm or above, with a sensitivity and specificity 94.1%(95%CI:89.4-97.1%) and 27.6%(95%CI:24.9-30.4%), respectively. The area under the curve (AUC) was 0.664 (95%CI: 0.637, 0.690, P<0.0001). Conclusion: In school tuberculosis outbreaks, if there are three or more student tuberculosis cases in a class or the TST moderate or strong positive rate is much higher than the normal range in the region, attention should be paid to the moderately positive TST. IGRAs were recommended to be conducted followed by TST on the day of reading results especially among students sharing the same class with the index case. In resource-poor areas lacking IGRAs, the induration diameter of TST can be appropriately reduced from 15mm to 9 mm to enhance the sensitivity of TST. |
| ISSN | 22352988 |
| DOI | 10.3389/fcimb.2022.972484 |
| Volume Number | 12 |
| Journal | Frontiers in Cellular and Infection Microbiology |
| Language | English |
| Publisher Date | 2022-10-13 |
| Access Restriction | Open |
| Subject Keyword | School Tuberculin skin test Interferon-gamma release assay Tuberculosis Outbreak |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology Microbiology Microbiology (medical) |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|