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| Content Provider | frontiers |
|---|---|
| Author | Zhang, Deyu Wu, Suna Pan, Shubo Wang, Meiqi Wang, Zhen He, Zixuan Zhang, Guanghao Cui, Fang Song, Yihang Li, Wanshun Shi, Xiaohua Huang, Haojie Xu, Huanhai |
| Abstract | Pancreatic adenosquamous carcinoma (ASPC) is a rare subtype of pancreatic cancer with lethal malignancy, and few studies have focused on the heterogeneity of ASPC. Here, we performed a single-cell sequencing procedure on pancreatic tumour tissue from an ASPC patient and a patient with high-grade IPMN. Through combined analysis of single-cell sequencing data from 5 PDAC patients, 1 IPMN patient and 1 ASPC patient in a public database, we identified 11 main types of cells, including macrophages, B cells, cancer stem cells, ductal cells, fibroblasts, endo/stellate cells, neutrophils, acinar cells, T cells, NK cells, dendritic cells and mast cells. Then, the different characteristics and differentiation paths of the immune microenvironment among IPMN, ASPC and PDAC in macrophages, T cells and cancer-associated fibroblasts (CAFs) were identified through multiple bioinformatics analyses. Two novel special cancer-associated fibroblasts were identified as nonreactive CAFs and i&my CAFs. Then, cancer cells in duct cells were identified using infercnv software. Two ASPC-specific subgroups of cancer cells with squamous cell features were identified. Finally, the identified specific CAFs and cancer cells were mapped to the TCGA-PAAD cohort through cibersoftx software. All of these identified subgroups were calculated to have significant prognostic value in pancreatic cancer patients. These findings will promote the clinical application of single-cell sequencing data of pancreatic cancer and deepen our understanding of ASPC. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2022.972298 |
| Volume Number | 13 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2022-08-16 |
| Access Restriction | Open |
| Subject Keyword | Single cell sequencing Pancreatic adenosquamous carcinoma Prognostic value Pancreatic Ductal Adenocarcinoma Heterogeneity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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