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| Content Provider | frontiers |
|---|---|
| Author | Ferri, Alberto Garcia-Roves, Pablo M. Pieroni, Luisa |
| Abstract | The development of OMICS sciences and in particular Proteomics provided new tools to study mitochondrial role in health and disease.This Research Topic aim to collect papers describing how evidences based on proteomics data can contribute to gain a deep understanding of mitochondrial structure and function and to unveil unknown or complicated aspects of mitochondrial physiological function and dysfunction.This exciting editorial initiative allows us to collect seven interesting articles.Three original research articles investigate mitochondrial proteome changes in response to non physiological stimuli such as the microenviromental modifications or neurdegenerative disease.The paper by Maffioli E. et al. (https://www.frontiersin.org/articles/10.3389/fcell.2020.00508/full) sheds light on mechanotransduction, a particular ability of cells to respond and adapt their structure and function to biophysical changes in their microenviroment. They studied this phenomenon in cellullar models of rodent pancreatic β cells cultured on artificial microenviroments, a nanostructured surfaces assembled by Supersonic Cluster Beam Deposition of zirconia nanoparticles. Following their previous study they used mass spectrometry based proteomics to investigate the involvement of mitochondria in this phenomenon. They show that mitochondria morphology and proteome can be regulated by nanotopography and this changes can drive a metabolic switch in these cells.Parkinson Disease is the topic of the r... |
| ISSN | 2296634X |
| DOI | 10.3389/fcell.2020.608753 |
| Volume Number | 8 |
| Journal | Frontiers in Cell and Developmental Biology |
| Language | English |
| Publisher Date | 2020-12-10 |
| Access Restriction | Open |
| Subject Keyword | Mitochondria Metabolism Post-translational modifications Neurodegeneration Proteome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology |
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