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| Content Provider | frontiers |
|---|---|
| Author | Mahazu, Samiratu Prah, Isaac Ayibieke, Alafate Sato, Wakana Hayashi, Takaya Suzuki, Toshihiko Iwanaga, Shiroh Ablordey, Anthony Saito, Ryoichi |
| Abstract | Extra-intestinal pathogenic Escherichia coli (ExPEC) is one of the world’s leading causes of bloodstream infections with high mortality. Sequence type 410 (ST410) is an emerging ExPEC clone resistant to a wide range of antibiotics. In this study, we investigated the epidemiology of 21 ST410 E. coli isolates from two Ghanaian hospitals. We also investigated the isolates within a global context to provide further insight into the dissemination of this highly pathogenic clone. A phylogenetic tree of the 21 isolate genomes, along with 102 others from global collection, was constructed representing the ensuing clades and sub-clades of the ST: A/H53, B2/H24R, B3/H24Rx, and B4/H24RxC. The carbapenem-resistant sub-clade B4/H24RxC is reported to have emerged in the early 2000s when ST410 acquired an IncX3 plasmid carrying a blaOXA-181 carbapenemase gene, and a second carbapenemase gene, blaNDM-5, on a conserved IncFII plasmid in 2014. In this study, we identified one blaOXA-181–carrying isolate belonging to B4/H24RxC sub-lineage and one carrying blaNDM-1 belonging to sub-lineage B3/H24Rx. The blaOXA-181 gene was found on a 51kb IncX3 plasmid; pEc1079_3. The majority (12/21) of our Ghanaian isolates were clustered with international strains described by previous authors as closely related strains to B4/H24RxC. Six others were clustered among the ESBL-associated sub-lineage B3/H24Rx and three with the globally disseminated sub-lineage B4/H24RxC. The results show that this highly pathogenic clone is disseminated in Ghana and, given its ability to transmit between hosts, it poses a serious threat and should be monitored closely. |
| ISSN | 1664302X |
| DOI | 10.3389/fmicb.2021.770130 |
| Volume Number | 12 |
| Journal | Frontiers in Microbiology |
| Language | English |
| Publisher Date | 2021-12-01 |
| Access Restriction | Open |
| Subject Keyword | B4H24RxC Oxacillinase-181 (OXA-181) ST410 B3/H24Rx Extra-intestinal pathogenic E. coli (ExPEC) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology Microbiology (medical) |
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