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| Content Provider | frontiers |
|---|---|
| Author | Ruoppolo, Giovanni Longo, Lucia Pescerelli, Patrizia Mango, Chiara Nicastri, Maria Flaccadoro, Flavia Mancini, Patrizia Greco, Antonio De Vincentiis, Marco |
| Abstract | Objectives. To evaluate the effectiveness of an adjuvant therapy (CoQ10 in its water-soluble form and Vitamin A) in supporting voice rehabilitation in a large group of patients with muscle tension dysphonia (MTD). Study Design. 12-week, double-blind, randomized, controlled, three-period cross-over pilot study. The primary endpoint was the change in the Dysphonia Severity Index (DSI) over the 12-week study period. Secondary endpoints were the changes in the subcomponents of DSI, including MPT, F0-high, I-low and jitter. Exploratory endpoints were the changes in the Shimmer and in Voice Handicap Index (VHI). Methods. Patients were randomly assigned in a 1:1 ratio to two counter-balanced arms. Group A (ADJ-PLA) patients were administered QTer 300 mg and Vit A acetate 500.000 Ul/g 1 mg twice daily for a 4-week intervention period, followed by a 4-week period of wash-out, and then were submitted to a last 4-week period of placebo. Patients in Group B (PLB-ADJ) were given the treatment period in reverse order. Both groups received a 45-minute voice therapy in a group format once a day for four weeks during the first and the second active periods. The therapy was held during the wash-out period. Results. The analysis of main time effect indicated a trend towards recovery of vocal function regardless of group assignment. A significant time by group effect was found on DSI (F =3.4 [2.5, 80.5], p=0.03), F0-high (F =4.5 [2.6, 82.9], p=0.008) and Shimmer (F =3.6 [1.5, 46.9], p=0.048), under CoQ10 and Vit A treatment, with a small effect size. There was no significant time by group effect on the other study measures, namely MPT, I-low, VHI. Conclusions. A trend towards recovery of vocal function was observed in all the patients, likely due to voice rehabilitation. The improvement of DSI was greater under CoQ10 and Vitamin treatment, indicating a more pronounced improvement of vocal quality under adjuvant therapy. |
| ISSN | 16639812 |
| DOI | 10.3389/fphar.2019.00939 |
| Volume Number | 10 |
| Journal | Frontiers in Pharmacology |
| Language | English |
| Publisher Date | 2019-09-10 |
| Access Restriction | Open |
| Subject Keyword | Dysphonia Severity Index Muscle tension dysphonia Vitamin A Voice rehabilitation CoQ10 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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