NDLI: Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling

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Tumor-Derived Extracellular Vesicles: Modulation of Cellular Functional Dynamics in Tumor Microenvironment and Its Clinical Implications

Identification of Immune-Related Subtypes and Characterization of Tumor Microenvironment Infiltration in Bladder Cancer

Replication of the Mammalian Genome by Replisomes Specific for Euchromatin and Heterochromatin

iPS Cell-Based Model for MAPT Haplotype as a Risk Factor for Human Tauopathies Identifies No Major Differences in TAU Expression

Synovial Fluid of Patient With Rheumatoid Arthritis Enhanced Osmotic Sensitivity Through the Cytotoxic Edema Module in Synoviocytes

Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation

Explaining Regeneration: Cells and Limbs as Complex Living Systems, Learning From History

Normothermic ex vivo Heart Perfusion Combined With Melatonin Enhances Myocardial Protection in Rat Donation After Circulatory Death Hearts via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis

miR-4732-3p in Extracellular Vesicles From Mesenchymal Stromal Cells Is Cardioprotective During Myocardial Ischemia

Biological Functions Driven by mRNAs Carried by Extracellular Vesicles in Cancer

The Role of the Signaling Pathways Involved in the Protective Effect of Exogenous Hydrogen Sulfide on Myocardial Ischemia-Reperfusion Injury

Novel Characterization of Myeloid-Derived Suppressor Cells in Tumor Microenvironment

Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach

Lack of miR-379/miR-544 Cluster Resists High-Fat Diet-Induced Obesity and Prevents Hepatic Triglyceride Accumulation in Mice

Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma

Editorial: Morphogenic Cascades Underlying Regeneration and Plasticity After Nervous System Injury

Targeting Ferroptosis to Treat Cardiovascular Diseases: A New Continent to Be Explored

HIV Tat-Mediated Induction of Monocyte Transmigration Across the Blood–Brain Barrier: Role of Chemokine Receptor CXCR3

A Novel Classifier Based on Urinary Proteomics for Distinguishing Between Benign and Malignant Ovarian Tumors

Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche

HCG18 Participates in Vascular Invasion of Hepatocellular Carcinoma by Regulating Macrophages and Tumor Stem Cells

Digitally Driven Aerosol Jet Printing to Enable Customisable Neuronal Guidance

Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review

Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases

Molecular Classification of Knee Osteoarthritis

Exosomes From M2 Macrophage Promote Peritendinous Fibrosis Posterior Tendon Injury via the MiR-15b-5p/FGF-1/7/9 Pathway by Delivery of circRNA-Ep400

Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective

Stimulation of Treg Cells to Inhibit Osteoclastogenesis in Gorham-Stout Disease

A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity

Effect of High Jugular Bulb on the Hearing Loss Characteristics in Patients With LVAS: A Pilot Study

Reproductive Suicide: Similar Mechanisms of Aging in C. elegans and Pacific Salmon

E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation

New Technologies With Increased Precision Improve Understanding of Endothelial Cell Heterogeneity in Cardiovascular Health and Disease

Protein Arginine Methyltransferase 5 Functions via Interacting Proteins

Extracellular and Intracellular Factors in Brain Cancer

PAX2+ Mesenchymal Origin of Gonadal Supporting Cells Is Conserved in Birds

Differentiation Between Glioblastoma Multiforme and Metastasis From the Lungs and Other Sites Using Combined Clinical/Routine MRI Radiomics

Establishment of Repertoire of Placentome-Associated MicroRNAs and Their Appearance in Blood Plasma Could Identify Early Establishment of Pregnancy in Buffalo (Bubalus bubalis)

Recognizing Pattern and Rule of Mutation Signatures Corresponding to Cancer Types

Identification of Immune Cell Infiltration Landscape and Their Prognostic Significance in Uveal Melanoma

Copy Number Signatures and Clinical Outcomes in Upper Tract Urothelial Carcinoma

Fluid Jet Stimulation of Auditory Hair Bundles Reveal Spatial Non-uniformities and Two Viscoelastic-Like Mechanisms

Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer

Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth

OCT4 Represses Inflammation and Cell Injury During Orchitis by Regulating CIP2A Expression

Autophagy-Related Genes and Long Noncoding RNAs Signatures as Predictive Biomarkers for Osteosarcoma Survival

LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer

High-Mobility Group A1 Promotes Cardiac Fibrosis by Upregulating FOXO1 in Fibroblasts

A New Pipeline to Automatically Segment and Semi-Automatically Measure Bone Length on 3D Models Obtained by Computed Tomography

Integrative Epigenome Map of the Normal Human Prostate Provides Insights Into Prostate Cancer Predisposition

Targeting the Microenvironment in Esophageal Cancer

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

Signaling Modulation by miRNA-221-3p During Tooth Morphogenesis in Mice

Absence of CD11a Expression Identifies Embryonic Hematopoietic Stem Cell Precursors via Competitive Neonatal Transplantation Assay

Single-Cell RNA-Sequencing Portraying Functional Diversity and Clinical Implications of IFI6 in Ovarian Cancer

The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction

Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction

Single-Cell Analysis Reveals Spatial Heterogeneity of Immune Cells in Lung Adenocarcinoma

Two Novel Pathogenic Variants of TJP2 Gene and the Underlying Molecular Mechanisms in Progressive Familial Intrahepatic Cholestasis Type 4 Patients

CircITGA7 Suppresses Gastric Cancer Progression Through miR-1471/MTDH Axis

Corrigendum: TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties

Blood–Brain Barrier, Cell Junctions, and Tumor Microenvironment in Brain Metastases, the Biological Prospects and Dilemma in Therapies

Substrate Stiffness Modulates the Growth, Phenotype, and Chemoresistance of Ovarian Cancer Cells

Generation of Multipotential NG2 Progenitors From Mouse Embryonic Stem Cell-Derived Neural Stem Cells

Fexofenadine Protects Against Intervertebral Disc Degeneration Through TNF Signaling

Cancer-Associated Fibroblasts Promote Vascular Invasion of Hepatocellular Carcinoma via Downregulating Decorin-integrin β1 Signaling

Effect of Gender to Fat Deposition in Yaks Based on Transcriptomic and Metabolomics Analysis

Editorial: Coupling and Uncoupling: Dynamic Control of Membrane Contacts

Transcriptomics Profiling Identifies Cisplatin-Inducible Death Receptor 5 Antisense Long Non-coding RNA as a Modulator of Proliferation and Metastasis in HeLa Cells

PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway

Plasma Metabolomic and Intestinal Microbial Analyses of Patients With Severe Aplastic Anemia

Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus Load

Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors

An Outside-In Switch in Integrin Signaling Caused by Chemical and Mechanical Signals in Reactive Astrocytes

Prioritizing Susceptible Genes for Thyroid Cancer Based on Gene Interaction Network

Ribosome Proteins Represented by RPL27A Mark the Development and Metastasis of Triple-Negative Breast Cancer in Mouse and Human

Aberrant Expression of Circulating MicroRNA Leads to the Dysregulation of Alpha-Synuclein and Other Pathogenic Genes in Parkinson’s Disease

Parkinson’s Disease: A Nanotheranostic Approach Targeting Alpha-Synuclein Aggregation

Editorial: Molecular and Cellular Underpinnings of Age-Related Memory Loss

Hypoxia in Bone and Oxygen Releasing Biomaterials in Fracture Treatments Using Mesenchymal Stem Cell Therapy: A Review

Selective Advantages of Synapses in Evolution

Editorial: Mechanisms of Neuronal Recovery in the Central Nervous System

The Primary Cilium on Cells of Developing Skeletal Rudiments; Distribution, Characteristics and Response to Mechanical Stimulation

Identification of the Immune-Related Genes in Tumor Microenvironment That Associated With the Recurrence of Head and Neck Squamous Cell Carcinoma

Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality

Correcting Artifacts in Ratiometric Biosensor Imaging; an Improved Approach for Dividing Noisy Signals

Editorial: Craniofacial Growth and Development: Novel Insights

Targeting the Urokinase-Type Plasminogen Activator Receptor (uPAR) in Human Diseases With a View to Non-invasive Imaging and Therapeutic Intervention

How Phagocytes Acquired the Capability of Hunting and Removing Pathogens From a Human Body: Lessons Learned From Chemotaxis and Phagocytosis of Dictyostelium discoideum (Review)

N6 -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice

CIRBP Knockdown Attenuates Tumourigenesis and Improves the Chemosensitivity of Pancreatic Cancer via the Downregulation of DYRK1B

The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy

A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer

Discovery of Novel Genetic Risk Loci for Acute Central Serous Chorioretinopathy and Genetic Pleiotropic Effect With Age-Related Macular Degeneration

Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis

G-Protein-Coupled Estrogen Receptor-1 Positively Regulates the Growth Plate Chondrocyte Proliferation in Female Pubertal Mice

Strategy for Leukemia Treatment Targeting SHP-1,2 and SHIP

GADD45B Is a Potential Diagnostic and Therapeutic Target Gene in Chemotherapy-Resistant Prostate Cancer

Oxidative Stress-Induced Ferroptosis in Cardiovascular Diseases and Epigenetic Mechanisms

Interplay Between Notch and YAP/TAZ Pathways in the Regulation of Cell Fate During Embryo Development

ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization

Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model

Current Pharmacological Strategies for Duchenne Muscular Dystrophy

Validation of the Relationship Between Iris Color and Uveal Melanoma Using Artificial Intelligence With Multiple Paths in a Large Chinese Population

Dynamin 3 Inhibits the Proliferation of Non-small-Cell Lung Cancer Cells by Suppressing c-MET–GBR2–STAT3 Complex Formation

The Roles of CCR9/CCL25 in Inflammation and Inflammation-Associated Diseases

KIAA1429 and ALKBH5 Oppositely Influence Aortic Dissection Progression via Regulating the Maturation of Pri-miR-143-3p in an m6A-Dependent Manner

Construction and Analysis of a Colorectal Cancer Prognostic Model Based on N6-Methyladenosine-Related lncRNAs

Super-Resolution Imaging Approaches for Quantifying F-Actin in Immune Cells

The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology

Loss of PIKfyve Causes Transdifferentiation of Dictyostelium Spores Into Basal Disc Cells

Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation

α1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis

Genetic Mechanism for the Cyclostome Cerebellar Neurons Reveals Early Evolution of the Vertebrate Cerebellum

Endothelial Cell: Lactate Metabolic Player in Organ Regeneration

Editorial: Fetal/Embryonic Hematopoietic Progenitors and Their Impact on Adult Diseases

CRISPR Toolbox for Genome Editing in Dictyostelium

Tissue Tregs and Maintenance of Tissue Homeostasis

Activation of Pancreatic Stellate Cells Is Beneficial for Exocrine but Not Endocrine Cell Differentiation in the Developing Human Pancreas

Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy

The Therapeutic Potential of Mesenchymal Stromal Cells for Regenerative Medicine: Current Knowledge and Future Understandings

ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

Comprehensive Analysis of RUNX and TGF-β Mediated Regulation of Immune Cell Infiltration in Breast Cancer

Hypermethylation and Downregulation of UTP6 Are Associated With Stemness Properties, Chemoradiotherapy Resistance, and Prognosis in Rectal Cancer: A Co-expression Network Analysis

Ventral Telencephalic Patterning Protocols for Induced Pluripotent Stem Cells

Lnc-GD2H Promotes Proliferation by Forming a Feedback Loop With c-Myc and Enhances Differentiation Through Interacting With NACA to Upregulate Myog in C2C12 Myoblasts

Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling

Novel Role of Gestational Hydralazine in Limiting Maternal and Dietary Obesity-Related Chronic Kidney Disease

The Application of Single-Cell RNA Sequencing in Mammalian Meiosis Studies

miRNA-7062-5p Promoting Bone Resorption After Bone Metastasis of Colorectal Cancer Through Inhibiting GPR65

TMEA, a Polyphenol in Sanguisorba officinalis, Promotes Thrombocytopoiesis by Upregulating PI3K/Akt Signaling

Understanding the Role of Endothelial Glycocalyx in Mechanotransduction via Computational Simulation: A Mini Review

Transcriptome Analysis in a Mouse Model of Premature Aging of Dentate Gyrus: Rescue of Alpha-Synuclein Deficit by Virus-Driven Expression or by Running Restores the Defective Neurogenesis

CircRNF111 Protects Against Insulin Resistance and Lipid Deposition via Regulating miR-143-3p/IGF2R Axis in Metabolic Syndrome

Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases

TMT-Based Proteomic Explores the Influence of DHEA on the Osteogenic Differentiation of hBMSCs

Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability

A Novel ARL3 Gene Mutation Associated With Autosomal Dominant Retinal Degeneration

CircCDYL Acts as a Tumor Suppressor in Wilms’ Tumor by Targeting miR-145-5p

SUMOylation in Phytopathogen Interactions: Balancing Invasion and Resistance

Opposite Roles of Tumor Cell Proliferation and Immune Cell Infiltration in Postoperative Liver Metastasis of PDAC

The Effects of Maternal Smoking on Pregnancy and Offspring: Possible Role for EGF?

S100 Calcium Binding Protein Family Members Associate With Poor Patient Outcome and Response to Proteasome Inhibition in Multiple Myeloma

CRISPR/Cas9-Mediated in vivo Genetic Correction in a Mouse Model of Hemophilia A

The Emerging Mechanisms of Wnt Secretion and Signaling in Development

Differential Roles of Actin Crosslinking Proteins Filamin and α-Actinin in Shear Flow-Induced Migration of Dictyostelium discoideum

A Hypothesis: Linking Phase Separation to Meiotic Sex Chromosome Inactivation and Sex-Body Formation

Critical View of Novel Treatment Strategies for Glioblastoma: Failure and Success of Resistance Mechanisms by Glioblastoma Cells

Allele-Specific Gene Editing Rescues Pathology in a Human Model of Charcot-Marie-Tooth Disease Type 2E

MeiosisOnline: A Manually Curated Database for Tracking and Predicting Genes Associated With Meiosis

AAV-Containing Exosomes as a Novel Vector for Improved Gene Delivery to Lung Cancer Cells

Organoids and Their Use in Modeling Gut Epithelial Cell Lineage Differentiation and Barrier Properties During Intestinal Diseases

Multifaceted Immunomodulatory Effects of the BTK Inhibitors Ibrutinib and Acalabrutinib on Different Immune Cell Subsets – Beyond B Lymphocytes

Non-coding RNA Activated by DNA Damage: Review of Its Roles in the Carcinogenesis

Long Non-Coding RNA SNHG6 Supports Glioma Progression Through Upregulation of Notch1, Sox2, and EMT

Vaginal Probiotic Lactobacillus crispatus Seems to Inhibit Sperm Activity and Subsequently Reduces Pregnancies in Rat

Regulation of Ferroptosis Pathway by Ubiquitination

The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases

Identification of Uterine Microbiota in Infertile Women Receiving in vitro Fertilization With and Without Chronic Endometritis

Psi-Caller: A Lightweight Short Read-Based Variant Caller With High Speed and Accuracy

Development of a Positive Selection High Throughput Genetic Screen in Dictyostelium discoideum

Above the Matrix: Functional Roles for Apically Localized Integrins

Exosomes Secreted by Microglia During Virus Infection in the Central Nervous System Activate an Inflammatory Response in Bystander Cells

Tools to Image Germplasm Dynamics During Early Zebrafish Development

They Might Cut It—Lysosomes and Autophagy in Mitotic Progression

Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors

An Ovarian Cancer Susceptible Gene Prediction Method Based on Deep Learning Methods

Staphylococcus aureus Infection Influences the Function of Intestinal Cells by Altering the Lipid Raft-Dependent Sorting of Sucrase–Isomaltase

RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis

The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration

Expanding the Chondroitin Sulfate Glycoproteome — But How Far?

Corrigendum: GABAergic System Dysfunction and Challenges in Schizophrenia Research

Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by Serotonin

Editorial: Impact on Embryonic Development of Chromatin Remodeling Alterations

Epidermal Lamellar Body Biogenesis: Insight Into the Roles of Golgi and Lysosomes

Microfluidics-Based Single-Cell Research for Intercellular Interaction

The Identification of the Metabolism Subtypes of Skin Cutaneous Melanoma Associated With the Tumor Microenvironment and the Immunotherapy

Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice

The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer

A Potential Method for Rapid Screening of Amphioxus Founder Harboring Germline Mutation and Transgene

In vitro Generation of Megakaryocytes and Platelets

Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis

The Paradoxical Role of Cellular Senescence in Cancer

GFP-Tagged Protein Detection by Electron Microscopy Using a GBP-APEX Tool in Drosophila

Transient Receptor Potential (TRP) Ion Channels Involved in Malignant Glioma Cell Death and Therapeutic Perspectives

Exploring Evidence of Non-coding RNA Translation With Trips-Viz and GWIPS-Viz Browsers

3D in vivo Magnetic Particle Imaging of Human Stem Cell-Derived Islet Organoid Transplantation Using a Machine Learning Algorithm

The Colloid Osmotic Pressure Across the Glycocalyx: Role of Interstitial Fluid Sub-Compartments in Trans-Vascular Fluid Exchange in Skeletal Muscle

3D Organoid Culture From Adult Salivary Gland Tissues as an ex vivo Modeling of Salivary Gland Morphogenesis

Discovery of Novel Host Molecular Factors Underlying HBV/HCV Infection

Opposite Roles for ZEB1 and TMEJ in the Regulation of Breast Cancer Genome Stability

Born to Run? Diverse Modes of Epithelial Migration

Class I PI3K Provide Lipid Substrate in T Cell Autophagy Through Linked Activity of Inositol Phosphatases

The Multifaceted Roles of Proline in Cell Behavior

Profilin Isoforms in Health and Disease – All the Same but Different

Editorial: Neurorepair Strategies to Induce Angiogenesis, Neurogenesis and Synaptic Plasticity

Homeotic Genes: Clustering, Modularity, and Diversity

Charging Up the Periphery: Glial Ionic Regulation in Sensory Perception

Changes in Wnt and TGF-β Signaling Mediate the Development of Regorafenib Resistance in Hepatocellular Carcinoma Cell Line HuH7

Differential and Prognostic Significance of HOXB7 in Gliomas

Combined DNA Methylation and Transcriptomic Assessments to Determine a Prognostic Model for PD-1-Negative Hepatocellular Carcinoma

Crystal Structure of Inorganic Pyrophosphatase From Schistosoma japonicum Reveals the Mechanism of Chemicals and Substrate Inhibition

Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming

TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage

Spatiotemporal and Functional Heterogeneity of Hematopoietic Stem Cell-Competent Hemogenic Endothelial Cells in Mouse Embryos

Magnesium Promotes the Regeneration of the Peripheral Nerve

Hearing Loss in Neurological Disorders

Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy

The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury

Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia

Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury

Combination of Melatonin and Zoledronic Acid Suppressed the Giant Cell Tumor of Bone in vitro and in vivo

B Cell Subset Analysis and Gene Expression Characterization in Mid-Luteal Endometrium

PUM1 Is Overexpressed in Colon Cancer Cells With Acquired Resistance to Cetuximab

An Insight Into the Mechanism of Plant Organelle Genome Maintenance and Implications of Organelle Genome in Crop Improvement: An Update

Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma

Effects of Iron and Zinc on Mitochondria: Potential Mechanisms of Glaucomatous Injury

Identification of Novel Metabolism-Associated Subtypes for Pancreatic Cancer to Establish an Eighteen-Gene Risk Prediction Model

Insight Into the Molecular Mechanism of Podophyllotoxin Derivatives as Anticancer Drugs

Investigating Optimal Autologous Cellular Platforms for Prenatal or Perinatal Factor VIII Delivery to Treat Hemophilia A

Potential Strategies to Improve the Effectiveness of Drug Therapy by Changing Factors Related to Tumor Microenvironment

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation

ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells

In situ Synthesized Monosodium Urate Crystal Enhances Endometrium Decidualization via Sterile Inflammation During Pregnancy

Identification of a Costimulatory Molecule Gene Signature to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma

Fucoidan-Supplemented Diet Potentiates Immune Checkpoint Blockage by Enhancing Antitumor Immunity

The Nitric Oxide Donor, S-Nitrosoglutathione, Rescues Peroxisome Number and Activity Defects in PEX1G843D Mild Zellweger Syndrome Fibroblasts

Single-Cell Transcriptome Profiling Reveals the Suppressive Role of Retinal Neurons in Microglia Activation Under Diabetes Mellitus

The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I

SYMPK Is Required for Meiosis and Involved in Alternative Splicing in Male Germ Cells

Proteinase Activated Receptors Mediate the Trypsin-Induced Ca2 + Signaling in Human Uterine Epithelial Cells

Epigenetic Control of Autophagy Related Genes Transcription in Pulpitis via JMJD3

A Non-invasive Chromosome Screening Strategy for Prioritizing in vitro Fertilization Embryos for Implantation

Sex-Specific Development in Haplodiploid Honeybee Is Controlled by the Female-Embryo-Specific Activation of Thousands of Intronic LncRNAs

Corrigendum: Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium

A Model of Waardenburg Syndrome Using Patient-Derived iPSCs With a SOX10 Mutation Displays Compromised Maturation and Function of the Neural Crest That Involves Inner Ear Development

Editorial: Molecular Links Between Mitochondrial Damage and Parkinson's Disease and Related Disorders

Development of the Pre-gnathal Segments in the Milkweed Bug Oncopeltus fasciatus Suggests They Are Not Serial Homologs of Trunk Segments

N6-Methyladenosine-Regulated mRNAs: Potential Prognostic Biomarkers for Patients With Lung Adenocarcinoma

Choline Kinase Alpha Is a Novel Transcriptional Target of the Brg1 in Hepatocyte: Implication in Liver Regeneration

TLE4 Is a Critical Mediator of Osteoblast and Runx2-Dependent Bone Development

Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man

TCF3 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells by Targeting PODXL

m6A Modification Mediates Mucosal Immune Microenvironment and Therapeutic Response in Inflammatory Bowel Disease

Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids

Study of lncRNA TPA in Promoting Invasion and Metastasis of Breast Cancer Mediated by TGF-β Signaling Pathway

Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma

Androgen Activity Is Associated With PD-L1 Downregulation in Thyroid Cancer

To the Surface and Back: Exo- and Endocytic Pathways in Trypanosoma brucei

HiPS-Endothelial Cells Acquire Cardiac Endothelial Phenotype in Co-culture With hiPS-Cardiomyocytes

Chondroitin Sulfate/Dermatan Sulfate-Protein Interactions and Their Biological Functions in Human Diseases: Implications and Analytical Tools

Comprehensive Analysis of Glycolysis-Related Genes for Prognosis, Immune Features, and Candidate Drug Development in Colon Cancer

A Comprehensive Genomic Analysis Constructs miRNA–mRNA Interaction Network in Hepatoblastoma

PI3K Plays an Essential Role in Planarian Regeneration and Tissue Maintenance

An Integrated Smart Sensor Dressing for Real-Time Wound Microenvironment Monitoring and Promoting Angiogenesis and Wound Healing

Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa Syndrome

Journey to the Center of the Cell: Cytoplasmic and Nuclear Actin in Immune Cell Functions

The Loss of Mitochondrial Quality Control in Diabetic Kidney Disease

Molecular Subtypes of Oral Squamous Cell Carcinoma Based on Immunosuppression Genes Using a Deep Learning Approach

Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia

The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases

When Viruses Cross Developmental Pathways

Long Non-coding RNA TMEM220-AS1 Suppressed Hepatocellular Carcinoma by Regulating the miR-484/MAGI1 Axis as a Competing Endogenous RNA

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Establishment of Mouse Primed Stem Cells by Combination of Activin and LIF Signaling

Canonical and Non-canonical Genomic Imprinting in Rodents

Ferroptosis, a Potential Therapeutic Target in Alzheimer’s Disease

Hypoxia-Inducible Factor 2-Alpha Mediated Gene Sets Differentiate Pulmonary Arterial Hypertension

Landscape of Prognostic m6A RNA Methylation Regulators in Hepatocellular Carcinoma to Aid Immunotherapy

CRISPs Function to Boost Sperm Power Output and Motility

Anterior Hox Genes and the Process of Cephalization

Translation of Cellular Protein Localization Using Convolutional Networks

Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development

Role of Long Non-coding RNAs on Bladder Cancer

Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges

Chromatin Conformation in Development and Disease

Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease

COX2 Enhances Neovascularization of Inflammatory Tenocytes Through the HIF-1α/VEGFA/PDGFB Pathway

Decreased Insulin Sensitivity in Telomerase-Immortalized Mesenchymal Stem Cells Affects Efficacy and Outcome of Adipogenic Differentiation in vitro

Dual DNA Transfection Using 1,6-Hexanedithiol-Conjugated Maleimide-Functionalized PU-PEI600 For Gene Correction in a Patient iPSC-Derived Fabry Cardiomyopathy Model

ANXA1 as a Prognostic and Immune Microenvironmental Marker for Gliomas Based on Transcriptomic Analysis and Experimental Validation

Uncharged Components of Single-Stranded DNA Modulate Liquid–Liquid Phase Separation With Cationic Linker Histone H1

ER Stress and Micronuclei Cluster: Stress Response Contributes to Genome Chaos in Cancer

Aging Negatively Impacts DNA Repair and Bivalent Formation in the C. elegans Germ Line

Sevoflurane Inhibits Traumatic Brain Injury-Induced Neuron Apoptosis via EZH2-Downregulated KLF4/p38 Axis

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Meta-Analysis-Assisted Detection of Gravity-Sensitive Genes in Human Vascular Endothelial Cells

Progress in Understanding Ferroptosis and Its Targeting for Therapeutic Benefits in Traumatic Brain and Spinal Cord Injuries

The Ascidia Ciona robusta Provides Novel Insights on the Evolution of the AP-1 Transcriptional Complex

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Current Trends and Research Topics Regarding Intestinal Organoids: An Overview Based on Bibliometrics

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GINS1 Induced Sorafenib Resistance by Promoting Cancer Stem Properties in Human Hepatocellular Cancer Cells

NAD+ in Alzheimer’s Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo

The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases

Low-Coverage Whole Genome Sequencing of Cell-Free DNA From Immunosuppressed Cancer Patients Enables Tumor Fraction Determination and Reveals Relevant Copy Number Alterations

The Prognosis and Immune Checkpoint Blockade Efficacy Prediction of Tumor-Infiltrating Immune Cells in Lung Cancer

Cell Interplay in Osteoarthritis

The Mammalian Family of Katanin Microtubule-Severing Enzymes

Identification of Biomarkers for Cervical Cancer Radiotherapy Resistance Based on RNA Sequencing Data

RNA Motifs and Modification Involve in RNA Long-Distance Transport in Plants

Role of Autophagy in the Maintenance of Stemness in Adult Stem Cells: A Disease-Relevant Mechanism of Action

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The Tyrosine Kinase-Driven Networks of Novel Long Non-coding RNAs and Their Molecular Targets in Myeloproliferative Neoplasms

Mesenchymal Stem Cells in Premature Ovarian Insufficiency: Mechanisms and Prospects

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N439K Variant in Spike Protein Alter the Infection Efficiency and Antigenicity of SARS-CoV-2 Based on Molecular Dynamics Simulation

Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders

Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells

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LncRNA CRNDE Promotes ATG4B-Mediated Autophagy and Alleviates the Sensitivity of Sorafenib in Hepatocellular Carcinoma Cells

ELK3 Mediated by ZEB1 Facilitates the Growth and Metastasis of Pancreatic Carcinoma by Activating the Wnt/β-Catenin Pathway

Editorial: Cardiomyocyte Maturation: Novel Insights for Regenerative Medicine

Identification of Claudin-6 as a Molecular Biomarker in Pan-Cancer Through Multiple Omics Integrative Analysis

Role of lncRNA BANCR in Human Cancers: An Updated Review

Insights Into the Mechanisms of Brain Endothelial Erythrophagocytosis

Prediction of Genetic Factors of Hyperthyroidism Based on Gene Interaction Network

Neural Tissue Homeostasis and Repair Is Regulated via CS and DS Proteoglycan Motifs

Generation of hiPSC-Derived Functional Dopaminergic Neurons in Alginate-Based 3D Culture

Immunological Value of Prognostic Signature Based on Cancer Stem Cell Characteristics in Hepatocellular Carcinoma

CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment

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Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling

Content Provider	frontiers
Author	Haack, Fiete Köster, Till Uhrmacher, Adelinde M.
Abstract	Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. A prominent example for the decisive impact of lipid rafts on signaling is LRP6, whose localization to the same lipid rafts domain as the kinase CK1y is crucial for its successful phosphorylation and the subsequent activation of the signalosome, hence WNT/beta-catenin signaling. However, according to various experimental measurements, approximately 25-35% of the cell plasma membrane is covered by nanoscopic raft domains with diameters ranging between 50 - 100 nm. Translating these values to the membrane of a "normal sized" cell yields a raft abundance, that, by far, outnumbers the membrane-associated pathway components of most individual signaling pathway, such as receptor and kinases. To analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/beta-catenin pathway activation, we present a computational modeling study, that for the first time employs realistic raft numbers in a compartment-based pathway model. Our simulation experiments indicate, that for receptor/raft ratios smaller than 1, i.e. when the raft number clearly exceeds the number of pathway specific membrane proteins, we observe significant decrease in LRP6 phosphorylation and downstream pathway activity. Our results suggest that pathway specific targeting and sorting mechanism are required to significantly narrow down the receptor/raft ratio and to enable the formation of the LRP6 signalosome, hence signalling.
ISSN	2296634X
DOI	10.3389/fcell.2021.706731
Volume Number	9
Journal	Frontiers in Cell and Developmental Biology
Language	English
Publisher Date	2021-08-18
Access Restriction	Open
Subject Keyword	Rule-based Modeling and Simulation Wnt/β-catenin signaling Receptor/raft ratio Compartmental modeling LRP6 receptor CK1γ LRP6 phosphorylation Lipid rafts
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology

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