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| Content Provider | frontiers |
|---|---|
| Author | Mahr, Alfred Hachulla, Eric de Boysson, Hubert Guerroui, Nassim Héron, Emmanuel Vinzio, Stéphane Broner, Jonathan Lapébie, François-Xavier Michaud, Martin Sailler, Laurent Zenone, Thierry Djerad, Mohamed Jouvray, Mathieu Shipley, Emilie Tieulie, Nathalie Armengol, Guillaume Bouldoires, Bastien Viallard, Jean-Francois Idier, Isabelle Paccalin, Marc Devauchelle-Pensec, Valérie |
| Abstract | Background: Since few studies of daily practices are available on patients with giant cell arteritis (GCA), this French study aimed to describe the characteristics and management of GCA patients in a real-life setting. Methods: Cross-sectional, non-interventional, multicenter study conducted in patients ≥50 years old who consulted hospital-based specialists for GCA and were under treatment. Patient characteristics and journey, diagnostic methods and treatments were collected. Descriptive analysis was performed. Results: 306 patients (females: 67%, 74±8 years old) were recruited by 69 physicians (internists: 85%, rheumatologists: 15%); 13% had newly diagnosed GCA (diagnosis-to-visit interval <6 weeks). Overall disease duration was 13 months (IQR: 5-26). Most patients were referred by GPs (56%), ophthalmologists (10%) and neurologists (7%). Most common comorbidities were hypertension (46%), psychiatric disorders (10%), dyslipidemia (12%), diabetes (9%), and osteoporosis (6%). Initial GCA presentations included cranial symptoms (89%), constitutional symptoms (74%), PMR (48%), and/or other extra-cranial manifestations (35%). TAB, high-resolution temporal artery Doppler, 18FDG-PET, and aortic angio-CT were performed for 85%, 31%, 26% and 30% of patients, respectively. All patients received glucocorticoids which were ongoing for 89%. 29% of patients also received adjunctive medication(s) (methotrexate: 19%, tocilizumab: 15%). 40% had relapse(s), median time to first relapse: 10 months. 37% had comorbidity(ies) related to or aggravated by GCs. Conclusion: This large observational study provides insight into current medical practices for GCA. More than one third of the patients have comorbidities related to GCs for a median disease duration of 13 months. Methotrexate and tocilizumab were the most common adjunct medications. |
| ISSN | 2296858X |
| DOI | 10.3389/fmed.2021.732934 |
| Volume Number | 8 |
| Journal | Frontiers in Medicine |
| Language | English |
| Publisher Date | 2021-11-11 |
| Access Restriction | Open |
| Subject Keyword | Management - Healthcare Phenotype [Mesh] Observational Giant Cell Arteritis Glucocorticoids (GCs) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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