NDLI: The effect of mental health interventions on psychological distress for informal caregivers of people with mental illness: A systematic review and meta-analysis

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Knowledge, attitude, and practice related to COVID-19: A comparison between patients with mental illness and the general population in Qatar

Changes in the geometry and robustness of diffusion tensor imaging networks: Secondary analysis from a randomized controlled trial of young autistic children receiving an umbilical cord blood infusion

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Computational analysis of probabilistic reversal learning deficits in male subjects with alcohol use disorder

Investigating post-traumatic stress disorder (PTSD) and complex PTSD among people with self-reported depressive symptoms

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A person-centered perspective on the combined DSM-5 AMPD/ICD-11 personality model: Utility, relationship with the categorical personality disorder model, and capacity to differentiate between levels of identity functioning

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Risks of suicide among family members of suicide victims: A nationwide sample of South Korea

Baseline global brain structural and functional alterations at the time of symptom onset can predict subsequent cognitive deterioration in drug-naïve first-episode schizophrenia patients: Evidence from a follow-up study

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Is acceptance and commitment therapy helpful in reducing anxiety symptomatology in people aged 65 or over? A systematic review

Motor impairments in Chinese toddlers with autism spectrum disorder and its relationship with social communicative skills

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Fear of COVID-19, prolonged smartphone use, sleep disturbances, and depression in the time of COVID-19: A nation-wide survey

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Baclofen in alcohol use disorder: An analysis of the data provided by the French “Temporary Recommendation for Use” 2014–2017 cohort

Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes

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The mental health status of offshore oil platform workers during the COVID-19 pandemic

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A methodological note on the CYP-guides randomized controlled trial for the treatment of major depression

Choices of (in)action in obesity: Implications for research on treatment and prevention

Behavioral pathway to a broken heart: The link between adverse childhood experiences, depression, physical exercise and cardiovascular health

Exploring the contextual factors, behaviour change techniques, barriers and facilitators of interventions to improve oral health in people with severe mental illness: A qualitative study

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Variations of cannabis-related adverse mental health and addiction outcomes across adolescence and adulthood: A scoping review

Brain morphometric abnormalities and their associations with affective symptoms in males with methamphetamine use disorder during abstinence

The changes in psychological symptoms of COVID-19 patients after “re-positive”

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Cognitive behavioral therapy with adaptive virtual reality exposure vs. cognitive behavioral therapy with in vivo exposure in the treatment of social anxiety disorder: A study protocol for a randomized controlled trial

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Prevalence and related factors of depressive symptoms among HIV/AIDS in Ningbo, China: A cross-sectional study

Factors influencing the efficiency of cellphone-based CBT for treating sleep disorders

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Sleep health among people with severe mental ill health during the COVID-19 pandemic: Results from a linked UK population cohort study

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Explanatory hypotheses of the ecology of new clinical presentations of Dissociative Identity Disorders in youth

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Psychological and behavioral characterization of suicide ideators and suicide attempters in adolescence

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Psychiatric symptoms and comorbidities in patients with drug-resistant epilepsy in presurgical assessment—A prospective explorative single center study

Using phenome-wide association studies and the SF-12 quality of life metric to identify profound consequences of adverse childhood experiences on adult mental and physical health in a Northern Nevadan population

The link between social communication and mental health from childhood to young adulthood: A systematic review

Adverse childhood experiences and fronto-subcortical structures in the developing brain

Corrigendum: Increased anxiety from fear of Omicron in China as compared to North America and Western Europe: A cross-sectional Kendall's tau-b analysis using the generalized anxiety disorder 7-item questionnaire

Mental burden among Chinese undergraduate medical students: A prospective longitudinal study before, during, and after the COVID-19 outbreak

Home-based transcranial direct current stimulation in dual active treatments for symptoms of depression and anxiety: A case series

Psychological outcomes and associated factors amongst healthcare workers during a single wave, deeper into the COVID-19 pandemic in China

The value of compassionate support to address smoking: A qualitative study with people who experience severe mental illness

Early development of treatment motivation predicts adherence and symptom reduction in an internet-based guided self-help program for binge eating disorder

Effectiveness of music therapy in children with autism spectrum disorder: A systematic review and meta-analysis

Characteristics inhibition defects of children with developmental dyscalculia: Evidence from the ERP

University freshmen's excessive smartphone use and psychological safety during the COVID-19 pandemic

Theory of mind and facial emotion recognition in adults with temporal lobe epilepsy: A meta-analysis

Adolescents’ online communication and well-being: Findings from the 2018 health behavior in school-aged children (HBSC) study

Editorial: New trends in psychiatric research: Toward the clinical characterization of the individual case and the personalization of treatments

Perspective: Decolonizing postmodernist approaches to mental health discourse toward promoting epistemic justice

The effect of mental health interventions on psychological distress for informal caregivers of people with mental illness: A systematic review and meta-analysis

Buprenorphine reduces methamphetamine intake and drug seeking behavior via activating nociceptin/orphanin FQ peptide receptor in rats

Validation of the generalized anxiety disorder scales (GAD-7 and GAD-2) in primary care settings in Latvia

The relationship between perceived social support with anxiety, depression, and insomnia among Chinese college students during the COVID-19 pandemic: The mediating role of self-control

Development and reliability of the coding system evaluating maternal sensitivity to social interactions with 34- to 36-week postmenstrual age preterm infants

Blood transcriptome analysis: Ferroptosis and potential inflammatory pathways in post-traumatic stress disorder

Neurocognitive impairment in addiction: A digital tool for executive function assessment

The effects of Baduanjin exercise vs. brisk walking on physical fitness and cognition in middle-aged patients with schizophrenia: A randomized controlled trial

Cultural lenses of the utility of the ICD-11-PD model: Integrating the Peruvian context

Correlation analysis between physicians' evaluations of doctor–patient relationship and their preferences for shared decision-making in China

Autoimmune antibodies in first-episode psychosis with red flags: A hospital-based case-control study protocol

Improved emotion regulation following a trauma-informed CBT-based intervention associates with reduced risk for recidivism in justice-involved emerging adults

Altered resting-state electroencephalography microstate characteristics in young male smokers

Effects of exercise on mortality rates of individuals with severe mental illness

Repetitive transcranial magnetic stimulation combined with cognitive behavioral therapy treatment in alcohol-dependent patients: A randomized, double-blind sham-controlled multicenter clinical trial

Effectiveness and safety of Jiuwei Zhenxin granules for treating generalized anxiety disorder: A randomized controlled trial

Commentary: Exploring the mental healthcare needs of Swiss pre-trial detainees: A pilot investigation of an on-site psychiatric day clinic

Editorial: Longitudinal data analysis in child and adolescent mental health

High-frequency repetitive transcranial magnetic stimulation alleviates the cognitive side effects of electroconvulsive therapy in major depression

Employing Respondent Driven Sampling (RDS) to recruit people who inject drugs (PWID) and other hard-to-reach populations during COVID-19: Lessons learned

See think act scale: Validation of the Dutch version of a measure of relational security in high secure forensic psychiatric care

Dynamic changes in mental health status related to the COVID-19 pandemic among health care workers and inpatients in China

Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging study

Altered resting-state functional connectivity of the dorsal anterior cingulate cortex with intrinsic brain networks in male problematic smartphone users

Unveiling mechanisms of change in digital interventions for depression: Study protocol for a systematic review and individual participant data meta-analysis

Case report: From anxiety disorders to psychosis, a continuum in transitional age youth?

3,4-Methylenedioxy methamphetamine, synthetic cathinones and psychedelics: From recreational to novel psychotherapeutic drugs

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The effect of mental health interventions on psychological distress for informal caregivers of people with mental illness: A systematic review and meta-analysis

Content Provider	frontiers
Author	Hansen, Nanja Holland Bjerrekær, Lasse Pallesen, Karen Johanne Juul, Lise Fjorback, Lone Overby
Abstract	Informal caregivers of people with a mental illness are at increased risk for developing depression, anxiety and stress, and preventive interventions are needed. The review was reported in Prospero, Id: CRD42018094454. PsycINFO, PubMed, and Scopus databases were searched June 2019, and the Cochrane Risk of Bias and Jadad scale score was used to assess study quality. Inclusion criteria were: RCTs of informal caregiver interventions regardless of care-receiver mental illness and intervention modality. Interventions should be compared to a waitlist, treatment as usual or active control, taught in real-time by a mental health professional, and include an outcome measure on psychological distress, published in a peer reviewed journal article in English. RCTs were excluded if the intervention was given in dyads (caregiver + care-receiver), limited to the provision of respite care, when the patient sample included a mix of both physical and psychological illness, were unpublished, not peer reviewed, a study protocol, or a dissertation. 2148 studies were identified, of those forty-four RCT studies met inclusion criteria and thirty-one studies had sufficient data to conduct a meta-analysis including subgroup analysis (N=1899). The systematic review showed that thirty-one out of forty-four RCTs had effect of the intervention on decreasing psychological distress. Results of the meta-analysis, which included informal caregiver interventions, compared to waitlist, treatment as usual, or active control, regardless of care-receiver mental illness, or intervention modality showed a small effect 0.34 (95% CI -0.55 to -0.13. Heterogeneity of the included studies was high (I2 78). Subgroup analysis including manualized interventions lasting at least eight-weeks and subgroup analysis that included an active control showed a small effect and low heterogeneity. Lack of active control and long-term follow-up are limitations in most studies. Evidence supports that several interventions improve mental health in caregivers. Manualized interventions, ≥ 8 weeks with active participation are effective. Future RCTs should improve methodology and research should investigate, which intervention modality is most effective for what kind of caregiver. Future research should clearly specify what the included interventions components are, use longer follow-up times and conduct mediational analyses to better understand what creates the effect of an intervention.
ISSN	16640640
DOI	10.3389/fpsyt.2022.949066
Volume Number	13
Journal	Frontiers in Psychiatry
Language	English
Publisher Date	2022-10-06
Access Restriction	Open
Subject Keyword	Psychological distress Meta-analysis Mental Health Interventions Systematic review Informal caregivers
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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