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| Content Provider | frontiers |
|---|---|
| Author | Murakami, Shin |
| Abstract | Age-related memory impairment (AMI), also called age-associated memory impairment (AAMI), describes the normal emergence and progression of memory problems associated with aging. It is one of diverse age-associated phenotypes found across a variety of organisms, including bees, fruit flies, nematodes, snails, rodents, and humans. The goal of this editorial is to provide an overview of our current understanding of AMI and its progression to more severe deficits related to advanced age and dementia. This research issue focuses on model systems and technologies relevant to cognitive aging and Alzheimer’s disease, and the study of AMI using invertebrate disease models.AMI can be viewed as a reduction in neuroplasticity, wherein the retention of existing memories is relatively well-preserved, compared with the ability to acquire new information. Aging specifically compromises mental processes underlying learning and some types of long-term memory, while leaving other types of long-term and procedural memories intact. AMI, however, may also include loss of existing memory, a condition termed age-related memory loss. In a simplified model, cognitive aging can be described to occur in the following sequence: AMI (normal state), mild cognitive impairment (MCI [transition state]), and then lastly, dementia (disease state). The neural mechanisms underlying the development of AMI into more advanced age-related disease remain unclear.A wide variety of model systems and comparative anal... |
| ISSN | 16648021 |
| DOI | 10.3389/fgene.2015.00366 |
| Volume Number | 6 |
| Journal | Frontiers in Genetics |
| Language | English |
| Publisher Date | 2016-01-12 |
| Access Restriction | Open |
| Subject Keyword | Dementia Model systems Patient Care Age-related memory impairment (AMI) Clinical practice Research outreach Alzheimer's disease Age-related memory loss Huntington Disease Cognitive aging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Medicine Genetics (clinical) |
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