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| Content Provider | frontiers |
|---|---|
| Author | Prieto-Davó, Alejandra Dias, Tiago Gomes, Sofia E. Rodrigues, Sara Parera-Valadez, Yessica Borralho, Pedro M. Pereira, Florbela Rodrigues, Cecilia M. P. Santos-Sanches, Ilda Gaudêncio, Susana P. |
| Abstract | Marine-derived actinomycetes have demonstrated an ability to produce novel compounds with medically relevant biological activity. Studying the diversity and biogeographical patterns of marine actinomycetes offers an opportunity to identify genera that are under environmental pressures, which may drive adaptations that yield specific biosynthetic capabilities. The present study describes research efforts to explore regions of the Atlantic Ocean, specifically around the Madeira Archipelago, where knowledge of the indigenous actinomycete diversity is scarce. A total of 400 actinomycetes were isolated, sequenced and screened for antimicrobial and anticancer activities. The three most abundant genera identified were Streptomyces, Actinomadura and Micromonospora. Phylogenetic analyses of the marine OTUs isolated indicated that the Madeira Archipelago is a new source of actinomycetes adapted to life in the ocean. Phylogenetic differences between offshore (>100m from shore) and nearshore (<100m from shore) populations illustrates the importance of sampling offshore in order to isolate new and diverse bacterial strains. Novel phylotypes from chemically rich marine actinomycete groups like MAR4 and the genus Salinispora were isolated. Anticancer and antimicrobial assays identified Streptomyces, Micromonospora and Salinispora as the most biologically active genera. This study illustrates the importance of bioprospecting efforts at unexplored regions of the ocean to recover bacterial strains with the potential to produce novel and interesting chemistry. |
| ISSN | 1664302X |
| DOI | 10.3389/fmicb.2016.01594 |
| Volume Number | 7 |
| Journal | Frontiers in Microbiology |
| Language | English |
| Publisher Date | 2016-10-07 |
| Access Restriction | Open |
| Subject Keyword | Marine actinomycetes Madeira Archipelago Natural product discovery Cultivable bacterial diversity Antimicrobial activity Anticancer activity Marine sediments Marine actinomycete phylogeny |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology Microbiology (medical) |
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