NDLI: Germacrene B - a central intermediate in sesquiterpene biosynthesis.

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Germacrene B - a central intermediate in sesquiterpene biosynthesis.

Content Provider	Europe PMC
Author	Xu, Houchao Dickschat, Jeroen S
Editor	Chen, David Yu-Kai
Copyright Year	2023
Abstract	Germacranes are important intermediates in the biosynthesis of eudesmane and guaiane sesquiterpenes. After their initial formation from farnesyl diphosphate, these neutral intermediates can become reprotonated for a second cyclisation to reach the bicyclic eudesmane and guaiane skeletons. This review summarises the accumulated knowledge on eudesmane and guaiane sesquiterpene hydrocarbons and alcohols that potentially arise from the achiral sesquiterpene hydrocarbon germacrene B. Not only compounds isolated from natural sources, but also synthetic compounds are dicussed, with the aim to give a rationale for the structural assignment for each compound. A total number of 64 compounds is presented, with 131 cited references.
Volume Number	19
PubMed Central reference number	PMC9972886
PubMed reference number	36865023
Journal	Beilstein Journal of Organic Chemistry [Beilstein J Org Chem]
e-ISSN	18605397
DOI	10.3762/bjoc.19.18
Language	English
Publisher	Beilstein-Institut
Publisher Date	2023-02-20
Publisher Place	Germany
Access Restriction	Open
Rights License	This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material. Copyright © 2023, Xu and Dickschat
Subject Keyword	biosynthesis configuration determination germacrene B structure elucidation terpenes
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

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