Loading...
Please wait, while we are loading the content...
Similar Documents
The m6A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m6A-Dependent Manner.
| Content Provider | Europe PMC |
|---|---|
| Author | Diao, Hongtao Tan, Huiling Hu, Yaju Wang, Ruonan Cai, Pingdong Huang, Bingying Shao, Xiaoqi Yan, Meiling Yin, Chuntong Zhang, Yue |
| Editor | Chen, Yongbin |
| Copyright Year | 2023 |
| Abstract | N6-methyladenosine (m6A) plays a significant role as an epigenetic mechanism, which is involved in various cancers’ progress via regulating mRNA modification. As a crucial m6A “reader”, YTHDF1 is able to alter m6A-modified mRNA and promote the protein translation process in multiple cancers. However, the role of YTHDF1 in lung cancer has not been fully investigated. This study focuses on elucidating the function of YTHDF1 in the development of lung cancer and its underlying mechanism. We demonstrated that YTHDF1 was highly expressed in lung carcinoma progression; then, the loss of function experiments in lung cell lines confirmed that knockdown of YTHDF1 suppressed cell proliferation, migration and invasion and induced ferroptosis of lung cancer cells. Further functional assays showed that ferritin (FTH) was identified as the key target of YTHDF1 in lung cancer cells. Furthermore, the overexpression of ferritin in YTHDF1-depleted cells partially restored lung cancer cell suppression. Collectively, our data suggested that the upregulation of YTHDF1 promotes lung cancer carcinogenesis by accelerating ferritin translation in an m6A-dependent manner. We hope that our findings may provide a new target for lung cancer diagnosis and treatment. |
| Volume Number | 16 |
| PubMed Central reference number | PMC9966794 |
| Issue Number | 2 |
| PubMed reference number | 37259333 |
| Journal | Pharmaceuticals (Basel) |
| e-ISSN | 14248247 |
| DOI | 10.3390/ph16020185 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-01-25 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | lung cancer YTHDF1 N6-methyladenosine (m6A) modification ferroptosis ferritin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science Molecular Medicine |
