Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study.

Content Provider	Europe PMC
Author	Cristóbal Quevedo, Ignacio Cristóbal García, Ignacio Gracia, Myriam Garcia-Pineda, Virginia Alonso-Espias, Maria Siegrist, Jaime Diestro, Maria Dolores Hernández, Alicia Zapardiel, Ignacio
Editor	Polterauer, Stephan Grimm, Christoph
Copyright Year	2023
Abstract	The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern and factors that might affect the oncological outcomes. A case-control ambispective study was carried out on consecutive patients at our center. Data on the SLN biopsy with ICG collected prospectively were compared to retrospective data on the use of a double-tracer technique including Technetium99 + ICG. In total, 194 patients were enrolled and assigned to both groups, in which the group with both tracers (controls) included 107 (54.9%) patients and the ICG-alone group (cases) included 87 (45.1%) patients. The rate of bilateral drainage was significantly higher in the ICG group (98.9% vs. 89.7%; p = 0.013). The median number of nodes retrieved was higher in the control group (three vs. two nodes; p < 0.01). We did not find survival differences associated with the tracer used (p = 0.85). We showed significant differences in terms of disease-free survival regarding the SLN location (p < 0.01), and obturator fossa retrieved nodes showed better prognosis compared to external iliac. The use of ICG as a single tracer for SLN detection in endometrial cancer patients seemed to obtain higher rates of bilateral detection with similar oncological outcomes.
Volume Number	13
PubMed Central reference number	PMC9966782
Issue Number	2
PubMed reference number	36836404
Journal	Journal of Personalized Medicine [J Pers Med]
e-ISSN	20754426
DOI	10.3390/jpm13020170
Language	English
Publisher	MDPI
Publisher Date	2023-01-18
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	endometrial neoplasms sentinel lymph node indocyanine green technetium
Content Type	Text
Resource Type	Article
Subject	Medicine