NDLI: Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility.

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Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility.

Content Provider	Europe PMC
Author	Didziokaite, Gabija Biliute, Gabija Gudaite, Jogaile Kvedariene, Violeta
Editor	Jeschke, Udo Tesarik, Jan
Copyright Year	2023
Abstract	Oxidative stress (OS) plays an important role in a variety of physiological and pathological processes of the female reproductive system. In recent years the relationship between OS and endometriosis has been of particular interest, and a theory has been suggested that OS may be a cause of endometriosis development. While the link between endometriosis and infertility is well established, minimal or mild stages of endometriosis are not considered to cause infertility. Increasing evidence of OS as a leading agent in the development of endometriosis has brought up a theory of minimal/mild endometriosis itself being one of the manifestations of high OS rather than a separate disease which directly causes infertility. Moreover, further development of the disease is thought to contribute to an increased production of reactive oxygen species (ROS) thus leading to the progression of endometriosis itself as well as to other pathological processes in the female reproductive system. Therefore, in case of minimal or mild endometriosis, the less invasive treatment could be offered in order to stop the ongoing cycle of endometriosis-reinforced excess ROS production and to reduce their harmful effects. In this article the existing connection between OS, endometriosis, and infertility is explored.
Journal	International Journal of Molecular Sciences [Int J Mol Sci]
Volume Number	24
DOI	10.3390/ijms24043809
PubMed Central reference number	PMC9966009
Issue Number	4
PubMed reference number	36835217
e-ISSN	14220067
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-02-14
Access Restriction	Open
Subject Keyword	oxidative stress reactive oxygen species infertility unexplained infertility endometriosis mild and minimal endometriosis
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications Medicine Inorganic Chemistry Organic Chemistry

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