Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions.

Content Provider	Europe PMC
Author	Fan, Liangxin Zhu, Xinxin Liu, Xingyuan He, Fangyu Yang, Guoyu Xu, Cuilian Yang, Xifa
Editor	Shu, Chao
Copyright Year	2023
Abstract	3,n-fused (n = 4-7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products.
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28041647
PubMed Central reference number	PMC9964631
Issue Number	4
PubMed reference number	36838635
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-02-08
Access Restriction	Open
Subject Keyword	palladium tricyclic indoles domino reaction catalyst total synthesis
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry