Wittig and Wittig-Horner Reactions under Sonication Conditions.

Content Provider	Europe PMC
Author	Ilia, Gheorghe Simulescu, Vasile Plesu, Nicoleta Chiriac, Vlad Merghes, Petru
Editor	Zbancioc, Gheorghita Moldoveanu, Costel
Copyright Year	2023
Abstract	Carbonyl olefinations are among the most important organic syntheses that form C=C bonds, as they usually have high yields and in addition offer excellent stereoselectivity. Due to these advantages, carbonyl olefinations have important pharmaceutical and industrial applications. These reactions contain an additional step of an α-functionalized carbanion to an aldehyde or ketone to produce alkenes, but syntheses performed using metal carbene complexes are also known. The Wittig reaction is an example of carbonyl olefination, one of the best ways to synthesize alkenes. This involves the chemical reaction between an aldehyde or ketone with a so-called Wittig reagent, for instance phosphonium ylide. Triphenylphosphine-derived ylides and trialkylphosphine-derived ylides are the most common phosphorous compounds used as Wittig reagents. The Wittig reaction is commonly involved in the synthesis of novel anti-cancer and anti-viral compounds. In recent decades, the use of ultrasound on the Wittig reaction (and on different modified Wittig syntheses, such as the Wittig-Horner reaction or the aza-Wittig method) has been studied as a green synthesis. In addition to the advantage of green synthesis, the use of ultrasounds in general also improved the yield and reduced the reaction time. All of these chemical syntheses conducted under ultrasound will be described further in the present review.
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28041958
PubMed Central reference number	PMC9964018
Issue Number	4
PubMed reference number	36838946
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-02-18
Access Restriction	Open
Subject Keyword	Wittig reaction Wittig–Horner synthesis ultrasound carbonyl olefination
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry