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Graft-versus-Host Disease Modulation by Innate T Cells.
| Content Provider | Europe PMC |
|---|---|
| Author | Fang, Ying Zhu, Yichen Kramer, Adam Chen, Yuning Li, Yan-Ruide Yang, Lili |
| Editor | Schmidt-Wolf, Ingo |
| Copyright Year | 2023 |
| Abstract | Allogeneic cell therapies, defined by genetically mismatched transplantation, have the potential to become a cost-effective solution for cell-based cancer immunotherapy. However, this type of therapy is often accompanied by the development of graft-versus-host disease (GvHD), induced by the mismatched major histocompatibility complex (MHC) between healthy donors and recipients, leading to severe complications and death. To address this issue and increase the potential for allogeneic cell therapies in clinical practice, minimizing GvHD is a crucial challenge. Innate T cells, encompassing subsets of T lymphocytes including mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells, and gamma delta T (γδ T) cells, offer a promising solution. These cells express MHC-independent T-cell receptors (TCRs), allowing them to avoid MHC recognition and thus GvHD. This review examines the biology of these three innate T-cell populations, evaluates research on their roles in GvHD modulation and allogeneic stem cell transplantation (allo HSCT), and explores the potential futures for these therapies. |
| Journal | International Journal of Molecular Sciences [Int J Mol Sci] |
| Volume Number | 24 |
| DOI | 10.3390/ijms24044084 |
| PubMed Central reference number | PMC9962599 |
| Issue Number | 4 |
| PubMed reference number | 36835495 |
| e-ISSN | 14220067 |
| Language | English |
| Publisher | Molecular Diversity Preservation International (MDPI) |
| Publisher Date | 2023-02-17 |
| Access Restriction | Open |
| Subject Keyword | graft-versus-host disease (GvHD) GvHD modulation innate T cell mucosal-associated invariant T (MAIT) cell invariant natural killer T (iNKT) cell gamma delta T (γδ T) cell major histocompatibility complex (MHC) T-cell receptor (TCR) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications Medicine Inorganic Chemistry Organic Chemistry |
