Efficiency in Carbon Dioxide Fixation into Cyclic Carbonates: Operating Bifunctional Polyhydroxylated Pyridinium Organocatalysts in Segmented Flow Conditions.

Content Provider	Europe PMC
Author	Poletti, Lorenzo Rovegno, Caterina Di Carmine, Graziano Vacchi, Filippo Ragno, Daniele Brandolese, Arianna Massi, Alessandro Dambruoso, Paolo
Editor	Puglisi, Alessandra
Copyright Year	2023
Abstract	Novel polyhydroxylated ammonium, imidazolium, and pyridinium salt organocatalysts were prepared through N-alkylation sequences using glycidol as the key precursor. The most active pyridinium iodide catalyst effectively promoted the carbonation of a set of terminal epoxides (80 to >95% yields) at a low catalyst loading (5 mol%), ambient pressure of CO2, and moderate temperature (75 °C) in batch operations, also demonstrating high recyclability and simple downstream separation from the reaction mixture. Moving from batch to segmented flow conditions with the operation of thermostated (75 °C) and pressurized (8.5 atm) home-made reactors significantly reduced the process time (from hours to seconds), increasing the process productivity up to 20.1 mmol(product) h-1 mmol(cat)-1, a value ~17 times higher than that in batch mode.
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28041530
PubMed Central reference number	PMC9960811
Issue Number	4
PubMed reference number	36838518
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-02-04
Access Restriction	Open
Subject Keyword	flow chemistry organocatalysis carbon dioxide cyclic carbonates mass transfer
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry