Untargeted Metabolite Profiling of Adipose Tissue in Rats Exposed to Mepiquat.

Content Provider	Europe PMC
Author	Hu, Chuanqin Song, Xinyu Shao, Zhenzhen Liu, Yingli Wang, Jing Sun, Baoguo
Editor	Santini, Antonello
Copyright Year	2023
Abstract	Mepiquat (Mep) is a contaminant produced by Maillard reaction with reducing sugar, free lysine and an alkylating agent under typical roasting conditions, particularly in the range of 200–240 °C. It has been reported that exposure to Mep is harmful to rats. However, its metabolic mechanism is still not clear. In this study, untargeted metabolomics was used to reveal the effect of Mep on the metabolic profile of adipose tissue in Sprague-Dawley rats. Twenty-six differential metabolites were screened out. Eight major perturbed metabolic pathways were found, which were linoleic acid metabolism, Phenylalanine, tyrosine, and tryptophan biosynthesis, phenylalanine metabolism, arachidonic acid metabolism, Glycine, serine, and threonine metabolism, glycerolipid metabolism, Alanine, aspartate, and glutamate metabolism, and glyoxylate and dicarboxylic acid metabolism. This study lays a solid foundation for clarifying the toxic mechanism of Mep.
Journal	Foods (Basel, Switzerland)
Volume Number	12
PubMed Central reference number	PMC9956293
Issue Number	4
PubMed reference number	36832941
e-ISSN	23048158
DOI	10.3390/foods12040867
Language	English
Publisher	MDPI
Publisher Date	2023-02-17
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	mass spectrometry food safety metabolomic untargeted metabolite profiling mepiquat
Content Type	Text
Resource Type	Article
Subject	Microbiology Health (social science) Health Professions Food Science Plant Science