Computational Prediction of Protein Intrinsically Disordered Region Related Interactions and Functions.

Content Provider	Europe PMC
Author	Han, Bingqing Ren, Chongjiao Wang, Wenda Li, Jiashan Gong, Xinqi
Editor	Yu, Chenglong Chen, Shuo Li, Shuai Huang, Hsin-Hsiung
Copyright Year	2023
Abstract	Intrinsically Disordered Proteins (IDPs) and Regions (IDRs) exist widely. Although without well-defined structures, they participate in many important biological processes. In addition, they are also widely related to human diseases and have become potential targets in drug discovery. However, there is a big gap between the experimental annotations related to IDPs/IDRs and their actual number. In recent decades, the computational methods related to IDPs/IDRs have been developed vigorously, including predicting IDPs/IDRs, the binding modes of IDPs/IDRs, the binding sites of IDPs/IDRs, and the molecular functions of IDPs/IDRs according to different tasks. In view of the correlation between these predictors, we have reviewed these prediction methods uniformly for the first time, summarized their computational methods and predictive performance, and discussed some problems and perspectives.
Journal	Genes (Basel)
Volume Number	14
PubMed Central reference number	PMC9956190
Issue Number	2
PubMed reference number	36833360
e-ISSN	20734425
DOI	10.3390/genes14020432
Language	English
Publisher	MDPI
Publisher Date	2023-02-08
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	intrinsically disordered proteins and regions interactions functions computational prediction
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)